@thejohnnyyu.bsky.social, @therealnima.bsky.social, and I, are excited to tell you about Tahoe-100M! The largest publicly available single-cell dataset that measures the effect of 1200 genes on 50 cell line models. The Vevo team has outdone itself. #Tahoe100M www.biorxiv.org/content/10.1... - ThreadSky

About ThreadSky

genophoria.bsky.social • 1 day ago

@thejohnnyyu.bsky.social, @therealnima.bsky.social, and I, are excited to tell you about Tahoe-100M! The largest publicly available single-cell dataset that measures the effect of 1200 genes on 50 cell line models. The Vevo team has outdone itself. #Tahoe100M https://www.biorxiv.org/content/10.1101/2025.02.20.639398v1

Comments

genophoria.bsky.social•1 day ago

When we started to work on scalable measurements of drug response many years ago, we never thought this scale was remotely possible! There is enough data in here to keep a cancer lab going for a few generations! https://www.biorxiv.org/content/10.1101/2024.12.13.628239v1

genophoria.bsky.social•1 day ago

But what gets me excited is how this data will supercharge our AI modeling efforts. And by our, I mean collectively the whole field.

genophoria.bsky.social•1 day ago

AI has begun to transform biology. From proteins to DNA, we have built capable foundation models that leverage unsupervised learning on large collections of publicly available data. Other domains in biology, however, remain beyond our grasp, largely because they are data poor domains.

genophoria.bsky.social•1 day ago

AI models of the cell, which we have come to know as “virtual cell”, is our next holy grail as we chart a path for bringing capable AI models to biology. Some of the greatest minds of the field have built new NN architectures to tackle this problem. https://www.cell.com/cell/fulltext/S0092-8674(24)01332-1

genophoria.bsky.social•1 day ago

It has become clear, however, that we are held back by data. And we are excited to be in a position to reshape the data landscape in one fell swoop. At 100M cellular measurements, Tahoe-100M increases the number of cells measured post-perturbation by 50 times.

genophoria.bsky.social•1 day ago

It is not just more single cell data… It is perturbational data!

Posting Rules

Be respectful to others
No spam or self-promotion
Stay on topic
Follow Bluesky's terms of service

Comments

Posting Rules

Reply