So happy to (finally!!) announce that our paper studying synovial tissue dendritic cells in joint health and rheumatoid arthritis is now out in Immunity! 🚨 https://doi.org/10.1016/j.immuni.2024.11.004
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• Tolerogenic AXL+ DC2s reside beneath the healthy synovial lining
• iDC3s populate RA hyperplastic lining, activating CCL5 Tem and/or Tph cells
• CCR7+ DC2s in sublining lymphoid niches in RA, interacting with naive T cells
• blood DC3s signature predicts RA flare