Lost in translation? Chloroplasts can handle slang! New study from our group at @lmumuenchen.bsky.social with great collabs @plantproteomics-ms.bsky.social @ifink-lab.bsky.social bsky.social‬ @hhu.de @wsupullman.bsky.social https://www.biorxiv.org/content/10.1101/2025.03.07.642005v1 🧵Often assumed - ThreadSky

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kunzlab.bsky.social • 13 days ago

Lost in translation? Chloroplasts can handle slang!
New study from our group at @lmumuenchen.bsky.social with great collabs @plantproteomics-ms.bsky.social @ifink-lab.bsky.social https://bsky.social‬ @hhu.de @wsupullman.bsky.sociahttps://www.biorxiv.org/content/10.1101/2025.03.07.642005v1v1 🧵Often assumed

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kunzlab.bsky.social•13 days ago

that gene expression works close to perfection, especially protein synthesis is a messy business. Bacteria use protein mistranslation since increased proteome plasticity can aid survival under stress conditions. The relationship of plant cells and their bacterial-type organelles towards protein

kunzlab.bsky.social•13 days ago

mistranslation was unknown. We isolated a Q➡️E hypermistranslating Arabidopsis mutant and show that plant cells are highly tolerant towards Q➡️E mistranslation in mitochondrial- and plastid-expressed proteins and even incorporate Q➡️E altered peptides into the photosynthetic machinery. Interestingly,

kunzlab.bsky.social•13 days ago

we find evidence that mistranslation in wild-type plants varies under stress conditions. This suggests that optimization of protein synthesis may improve plant stress tolerance. Moreover, the initial discovery of a hypermistranslating Arabidopsis mutant will benefit

kunzlab.bsky.social•13 days ago

other community members e.g., studying proteostasis, protein quality mechanism, and retrograde signaling. We hope you enjoy reading our preprint. Thank you.

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