Have you wondered whether fast spatiotemporal brain dynamics like traveling waves are local, confined to just one region, or whether they are shared across many regions simultaneously? The latest work from Zhiwen Ye in my lab has the answer! Thread- www.biorxiv.org/content/10.1... - ThreadSky

steinmetzneuro.bsky.social • 437 days ago

Have you wondered whether fast spatiotemporal brain dynamics like traveling waves are local, confined to just one region, or whether they are shared across many regions simultaneously? The latest work from Zhiwen Ye in my lab has the answer! Thread-
https://www.biorxiv.org/content/10.1101/2023.12.07.570517

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steinmetzneuro.bsky.social•437 days ago

Traveling waves of activity have been observed in many brain regions and species, usually just in one area per paper. Should we think that each brain region has its own wave dynamics, kept hidden from its synaptic partners? Or have we just been unable to see the big picture?

steinmetzneuro.bsky.social•437 days ago

In this work, Zhiwen discovered a new type of spiral wave dynamics in the mouse brain, identified a matching axonal architecture, and showed that this striking activity pattern is distributed across cortex and subcortical areas at once.

steinmetzneuro.bsky.social•437 days ago

(no gifs on bsky, what the heck? Guess you can see it at this dropbox link - https://www.dropbox.com/scl/fi/m278nini7po73aecnekjx/spiralClip-2.gif?rlkey=bh5552dqlj0qok8fqzby37jkl&dl=0 )

steinmetzneuro.bsky.social•437 days ago

We found prominent spiral waves that were commonly centered in the middle of somatosensory and motor cortex. We could see these with widefield calcium imaging and with ephys in cortex.

steinmetzneuro.bsky.social•437 days ago

Shockingly (to us), an open dataset of axonal reconstructions revealed that cortical neurons have axonal branching patterns that actually match this circular arrangement.

steinmetzneuro.bsky.social•437 days ago

Combining widefield imaging and Neuropixels ephys from thalamus, striatum, and midbrain, we found that these traveling waves were shared across all these regions, and multiple areas of cortex, simultaneously. Check out the paper for details on how we quantified this.

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