So much of Behavioral Neurology’s knowledge can be visualized through a data-driven, self-assembled graph of FDG-PET metabolic patterns across neurodegenerative and non-degenerative clinical diagnoses. 📊✨ #Neurology #FDGPET #BrainImaging #DataScience #Neurodegeneration #endalz - ThreadSky

davidjonesbrain.bsky.social • 101 days ago

So much of Behavioral Neurology’s knowledge can be visualized through a data-driven, self-assembled graph of FDG-PET metabolic patterns across neurodegenerative and non-degenerative clinical diagnoses. 📊✨

#Neurology #FDGPET #BrainImaging #DataScience #Neurodegeneration #endalz

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davidjonesbrain.bsky.social•30 days ago

aitchbi.bsky.social•99 days ago

Looks interesting.. but what do the nodes (patients?) & edges (spatial similarity bw FDG-PET?) represent?

davidjonesbrain.bsky.social•99 days ago

Nodes are patients bolted by neurologic diagnoses. Edges are a vector representation of their FDG-PET interpreted as a read out of their Global Functional State Space (GFSS). I use this investigational tool in my practice called StateViewer: https://naip.mayo.edu/

davidjonesbrain.bsky.social•99 days ago

Bolted = colored

davidjonesbrain.bsky.social•99 days ago

https://www.nature.com/articles/s41467-022-29047-4

aitchbi.bsky.social•99 days ago

Nice! & thanks for the reference! I assume you mean the “distance” bw the vector embeddings (in GFSS) of pairs of patients based on a nearest neighbor threshold determines presence/absence of edges; or just the actual “distance” if edges are weighted.

davidjonesbrain.bsky.social•99 days ago

Yes, the edge is a similarity measurement (cosine in this case) between pairs of GFSS vector embedding of the patient’s FDG-PET.

nissenbodil.bsky.social•98 days ago

📌

nyc118.bsky.social•100 days ago

This is so interesting to me. The first thing my daughter and I noticed with my husband was language (he pronounced words differently). Then came executive reasoning. He could no longer understand what he read. Memory was last and little impacted.

davidjonesbrain.bsky.social•100 days ago

Thank you for sharing! Unfortunately, your experience is not uncommon and the current system has a hard time incorporating these individual differences into medical care. We use average descriptions that lose the individual person.

nyc118.bsky.social•100 days ago

He was diagnosed with LBD (not what you would want as most nursing homes will not admit) but brain autopsy showed AD. He only spent 40 days away from home.

reddog2.bsky.social•101 days ago

Welcome, btw, there is a strong culture of including alt text here. It is also much appreciated.

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