As my inaugural post on BlueSky, I’m happy to share the first cancer-related study from Pyrocellfluencers spearheaded by Sara Orehek. www.nature.com/articles/s41... - ThreadSky

ivahb.bsky.social • 57 days ago

As my inaugural post on BlueSky, I’m happy to share the first cancer-related study from Pyrocellfluencers spearheaded by Sara Orehek.
https://www.nature.com/articles/s41467-024-55083-3

Comments

ivahb.bsky.social•57 days ago

Inspired by inflammasomes that protect against infection by secretion of cytokines and cell death we present cytokine-armed pyroptosis as a synthetic alternative to natural inflammasomes that might be suppressed in cancer cells.

ivahb.bsky.social•57 days ago

To induce immunogenic cell death, we generated a toolbox of gasdermin D variants with different modes of regulation and strength of cell death induction.
https://www.nature.com/articles/s41467-024-55083-3/figures/1

ivahb.bsky.social•57 days ago

In the mouse B16 melanoma model, the intratumoral electrogenic transfer of plasmid encoding pyroptosis inducer leads to the long-term tumor-free survival of approximately 20% of treated animals.
https://www.nature.com/articles/s41467-024-55083-3/figures/2

ivahb.bsky.social•57 days ago

When pyroptosis induction is preceded by the intratumoral expression of IL-1beta or IL-18, the effect of cell death induction on tumor-free survival is enhanced.
https://www.nature.com/articles/s41467-024-55083-3/figures/4

ivahb.bsky.social•57 days ago

We show that also inflammasome-unrelated cytokine IL-12 can be used to boost the therapeutic effect of intratumoral pyroptosis induction.
https://www.nature.com/articles/s41467-024-55083-3/figures/5

ivahb.bsky.social•57 days ago

However, some cytokines such as a combination of IL-1b and IL-18 abort the protective effect of pyroptosis!
https://www.nature.com/articles/s41467-024-55083-3/figures/7

colllab.bsky.social•57 days ago

Great to see this out Iva!! Congratulations and a very Happy New Year! 🎊

ivahb.bsky.social•57 days ago

Thanks Rebecca! Happy New Year!

mrmarkham.bsky.social•57 days ago

Cool. And a warm and hearty welcome to you!

ivahb.bsky.social•57 days ago

Thank you Jeffrey, happy new year!

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