I am excited to share the last work of my postdoc as a Swartz Fellow at NYU on the dynamic routing of large-scale cognitive networks in the neocortex! 🌐🧠 Here's a quick breakdown: 🧵 preprint: www.biorxiv.org/content/10.1... - ThreadSky

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ulisespereirao.bsky.social • 82 days ago

I am excited to share the last work of my postdoc as a Swartz Fellow at NYU on the dynamic routing of large-scale cognitive networks in the neocortex! 🌐🧠 Here's a quick breakdown: 🧵

preprint: https://www.biorxiv.org/content/10.1101/2024.11.01.621513v2

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ulisespereirao.bsky.social•82 days ago

1/ What’s the big question? How does the neocortex reorganize activity across cognitive networks like the Default Mode Network (DMN) and Dorsal Attention Network (DAN)? 🤔 These networks control whether you're focused on the external world or internal thoughts.

ulisespereirao.bsky.social•82 days ago

2/ Neocortex-wide neural activity is organized into distinct networks engaged in different cognitive processes. These networks flexibly reconfigure, but the mechanisms enabling this remain unclear. What’s the mechanism?

ulisespereirao.bsky.social•82 days ago

3/ Current recordings suggest long-range projections act as bottlenecks or "communication subspaces" (Semedo et al. 2019) that selectively route some neural activity while keeping others private. 🧠🔗
This inspired us to ask: Could these subspaces coordinate cognitive networks?

ulisespereirao.bsky.social•82 days ago

4/Inspired by this idea we developed connectivity-constrained whole-cortex models for macaques and humans.

ulisespereirao.bsky.social•82 days ago

5/ Within-area connectivity includes symmetric, asymmetric, and random motifs, generating stable (attractor) or transient (sequential) dynamics.
Inter-areal connectivity is sparse, low-rank, and random, constrained by cognitive network activation maps.

ulisespereirao.bsky.social•82 days ago

6/ Our findings explain key cognitive processes:
🔹 How networks like DMN & DAN compete to focus attention
🔹 How the Multiple Demand Network (MDN) flexibly couples to these networks to decide what deserves attention
🔹 How salient stimuli drive global shifts in network activity

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