Important study which adds to a growing literature associating worse outcomes with “renally adjusted” beta-lactam dosing. Major confounder is that renal failure itself is associated with increased mortality. Reality is, however, we are really bad at predicting plasma drug levels in patients.
Reposted from
Antibiotic Steward 🅱️C🆔🅿️🌟
Are we jumping the gun? 🧪
A 🆕💫 retrospective study shows higher mortality rate in patients with KPC Klebsiella BSIs treated with renal-adjusted doses ceftazidime-avibactam regardless of kidney disease status
Time to rethink our dosing strategy? #idsky #medsky #EMIMCC
academic.oup.com/jacamr/artic...
A 🆕💫 retrospective study shows higher mortality rate in patients with KPC Klebsiella BSIs treated with renal-adjusted doses ceftazidime-avibactam regardless of kidney disease status
Time to rethink our dosing strategy? #idsky #medsky #EMIMCC
academic.oup.com/jacamr/artic...
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