ER stress during heterologous protein production triggers the unfolded protein response (UPR), which can lower yields if unresolved. A study using N. benthamiana shows how transiently expressed H5 proteins reveal this mechanism. 🧬
Comments
Log in with your Bluesky account to leave a comment
When producing mAbs (mAb1 & mAb2), the protein causing stronger ER stress led to necrotic symptoms and poor yields. This highlights the need to manage ER stress for efficient plant-based protein expression. 🌟
Comments
🔗pubmed.ncbi.nlm.nih.gov/38038125