The image illustrates the intricate quality-control process within the ER and
highlights the role of IRGQ in MHC-I quality control. Here, a hepatocellular carcinoma cell is shown as a busy factory producing garden scissors, that symbolize MHC-I molecules with light and heavy chains.
highlights the role of IRGQ in MHC-I quality control. Here, a hepatocellular carcinoma cell is shown as a busy factory producing garden scissors, that symbolize MHC-I molecules with light and heavy chains.
Comments
up unassembled or discarded, resulting in unproductive chain production and signaling in cells.
(text adapted from Heraus et al. cover submission)