Different conformations get assembled: close, “ready-for-sale”, pink; open, “non-conformational”, green; halves, free heavy chains, yellow. While pink scissors get displayed on a shelf for sale (plasma membrane), IRGQ discards defective ones into a bin (the autophagosome), ensuring quality control.
Comments
up unassembled or discarded, resulting in unproductive chain production and signaling in cells.
(text adapted from Heraus et al. cover submission)