the proteasome still holds secrets – amazing new study shows how midnolin drives ubiquitin-independent degradation, repurposing proteasomal Rpn11 to act as a receptor not a deubiquitinase, while PSMD2 anchors midnolin via its NLS motif. wow. congrats to all authors.
https://www.biorxiv.org/content/10.1101/2025.02.22.639686v1