How did I miss this preprint, posted in June?
Looks really intersting.
They suggest transfer of mRNA, ribosomes & translating ribosomes through #TunnelingNanotubes in pancreatic cancer, promoted by chemo.
Added to the reading pile.
#RNASky #RNABiology #Cytoskel 🧪🔬
https://www.biorxiv.org/content/10.1101/2024.06.06.597772v2.full
Looks really intersting.
They suggest transfer of mRNA, ribosomes & translating ribosomes through #TunnelingNanotubes in pancreatic cancer, promoted by chemo.
Added to the reading pile.
#RNASky #RNABiology #Cytoskel 🧪🔬
https://www.biorxiv.org/content/10.1101/2024.06.06.597772v2.full
Comments
In most #TunnelingNanotube research i'm familiar with this is ruled out.
In any case, cells typically don't fuse together unless there's a good reason for that.
Cells do fuse together, the actual rate and relevance is unknown but probably relevant because
Fusion can also be used in the lab to immortalize a cell that produce a given protein. Historically this has only been used for antibodies production, but in theory it could be used to produce any protein
https://en.wikipedia.org/wiki/Hybridoma_technology
Cell fusion has multiple roles in healthy humans, from organogenesis to tissue repair, and can be a advantage for tumors
https://pubmed.ncbi.nlm.nih.gov/27136533/
most cell to cell fusions instances in adulthood are unknown because the topic is unknown hence understudied
The hard part is to find time to actually read it 😫