Saturation mutagenesis CRISPR screen to map CREs of PD-L1

+ TFs CRISPR LoF screen to identify known & novel trans-regulators

+ CUT&RUN to confirm new regulators

+ HiChIP enhancers/promoters contact maps

Very impressive work by @nevillesanjana.bsky.social

https://www.biorxiv.org/content/10.1101/2024.11.27.625752v1