This is a superb piece of work, really important in understanding the contribution RNAi might make to immunity in mammals. Why antiviral RNAi is not that important in mammals is a really interesting puzzle for evolution since this function is likely ancestral. Drift, or selection against it?
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Petr Svoboda
1/n So, this is out in NAR, finally. The longest, the most expensive and the most challenging project in the lab. Sparked by controversy concerning mammalian antiviral RNAi and our identification of Dicer variant, which is sufficient to increase RNAi.
doi.org/10.1093/nar/...
doi.org/10.1093/nar/...
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