Indeed, 1 A.A. mutation from each of these hotspots dramatically extended the pulsatory response (>18 hrs vs 10s of min), suggesting evolutionary tuning of dynamics.
Many questions (what benefits of protein dynamics for the host fungus?) and implications (better/new opto or thermo proteins). Overall, intra-protein network motifs provide a new way to think about compact, dynamic computation on the protein level.
Grateful for a true collaboration with @nmrkaygee.bsky.social lab at CUNY, with @malvinf.bsky.social and @Kevin Gardner leading the in vitro studies. Huge thank you to Lukasz for all the support! This work was also only possible with funding for curiosity-driven research by NIH, NSF, and Penn.
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