Really nice new paper using transfer learning with precise TF dose modulation to predict how chromatin accessibility at REs responds to changes in TF levels, also showing how TF dose perturbations can induce distinct phenotypes, even within shared cellular contexts, but lots of questions remain!
Reposted from
Eric Kernfeld
Many reporter assays assume that the determinants of expression are 1) DNA sequence and 2) trans-acting soluble factors. It's ambitious but natural to want to model dose response to regulators as a function of DNA sequence, and I'm excited to see this.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
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