Do our genes sabotage our bodies?
@haoyin.bsky.social reviewed a bioRxiv paper that suggests a special gene helps melanoma (a type of skin cancer) grow and evade the immune system. 🧵1/7
@haoyin.bsky.social reviewed a bioRxiv paper that suggests a special gene helps melanoma (a type of skin cancer) grow and evade the immune system. 🧵1/7
Comments
→ tumor growth
→ the tumor’s microenvironmentÂ
→ interactions with the immune system
→ The paper systematically analyzes melanoma genes using patient data, cell lines, and mice
→ Strong evidence that HOXD13 aids melanoma growth by driving angiogenesis, and immune evasion and affecting VEGFA/SEMA3 and CD73-adenosine pathways
→ Only male mice were used, limiting applicability to both sexes
→ HOXD13’s role in metastasis wasn’t tested in animals
→ The study adds molecular insights, but HOXD13’s oncogenic role is already known
→ The efficacy of potential treatments was tested in a modified model
→ More clarity on virus concentration in the experiment needs to be provided
→ Results need more protein-level evidence and details about tumor growth conditions
→ Additional data (such as spatial correlations in tumor samples) would strengthen conclusions
Read the full review on ResearchHub →
https://www.researchhub.com/paper/8946915/a-targetable-developmental-program-co-regulates-angiogenesis-and-immune-evasion/reviews