aidoq.bsky.social - Profile | ThreadSky | a Reddit-style client for Bluesky

The world lost a truly brilliant scientist & professor Dickson epitomized the joyful curiosity, collaboration and broadly engaging nature that is the whole point of academic science He inspired me to join Columbia PhD program and no doubt inspired countless more around the world on TWiV & TWiP 🧬🦠 🧪

submitted 7 days ago • 3 comments

Super nice cancer #biomarker study! Low cost, and fairly sensitive, making strides toward a screening test for early-stage pancreatic #cancer. Doesn’t appear to be quite specific enough for use in broad populations but looks promising! Early detection in pancreatic cancer will be game-changer 🧪

submitted 10 days ago • 0 comments

These moves feel targeted at the big, elite research institutes - and no doubt it hurts - but often labs at the big research schools have private funding to buffer #NIH losses. Make no mistake, this will hurt all research but especially smaller, local universities and new labs

submitted 14 days ago • 1 comment

The Boston sunset view from my bench never gets old! 🧪

submitted 21 days ago • 2 comments

Finally had a chance to read this one from Rabadan group @columbiamed.bsky.social It’s amazing the information stored in accessibility profiles! The generalized expression model they learned can accurately predict TF activity & interactions and infer cis regulatory elements #epigenetics 🧪 🧬

submitted 21 days ago • 0 comments

Affected by #NIH and #NFS funding cuts? Considering a move abroad to escape? I haven't advertised this yet, but I have fresh funding for 2 senior #postdoc positions in #oxford. If you're into #Cancer #genomics and #epigenetics then get in touch. Please RT 🙏

submitted 22 days ago • 0 comments

Hey science 🧪 bluesky! Anyone have suggestions for benchtop bioprocess controllers / bioreactors for mammalian cell culture? I’m looking at the Eppendorf SciVario Twin (maybe 320?) or the Thermo G3Lab system. Any other systems I should consider? Thanks! 🧬 🧫 🦠

submitted 24 days ago • 1 comment

Awesome recap, so many exciting developments!!

submitted 50 days ago • 0 comments

🔬Decoding Silencing: How Heterochromatin Transcribes to Silence Itself! 🧬 Discover how a pioneer transcription factor-like complex infiltrates repressive heterochromatin, producing transcripts with hidden introns that kickstart RNAi-mediated heterochromatin formation www.nature.com/articles/s41...

submitted 51 days ago • 1 comment

We often speak about chromatin as being accessible or inaccessible, but what does it mean? We wrote a short review on this, 🔬 focused: sciencedirect.com/science/arti... A big thank you to Tom Fillot for his efforts on this and to @hansen_lab @marcelonollmann for their help as editors.

submitted 65 days ago • 4 comments

Very cool tool to systematically study enhancer-promoter functional interactions! Beautiful work, @jk-swietek.bsky.social!

submitted 68 days ago • 0 comments

Really nice, sweeping overview of the role and key regulators of chromatin accessibility across a wide range of diseases. Great review for anyone getting started in the #epigenetics and #chromatin fields!

submitted 78 days ago • 0 comments

Hey #Epigenetics folks! I made a starter pack, please comment below if you’d like to be added or have any suggestions for great epigenetics researcher I’ve missed! Cheers! 🧪🧬🔬 go.bsky.app/7JubtEj

submitted 79 days ago • 1 comment

Aged lung adult stem cells are less susceptible to malignant transformation by kras + p53 mutation. Suggests that age-related loss of ‘stemness’ is associated with increased barrier to transformation. Demonstrating why it’s so important to directly test assumptions in biology! 🧪 🧬🔬 (1/3)

submitted 79 days ago • 2 comments

AI scientists (LLMs) control a highly automated lab to successfully design novel nanobodies showcasing its #AI potential to deliver scientific advances with minimal, high-level human oversight. 🧪

submitted 80 days ago • 1 comment

Toward a fully automated clinical pathologist! Very exciting use case for #AI models in #cancer research - could help enroll patients in clinical trials from community/smaller hospitals, a win for inclusion and equity in clinical stage research

submitted 86 days ago • 0 comments

Hey #epigenetics folks! Who am I missing here on @bsky.app? Tag below and I’ll add folks who do amazing epigenetic research!

submitted 91 days ago • 0 comments

"Dark TFs": new manuscript mapped 166 uncharacterized human transcription factors, finding half bind genomic "dark matter," often closed chromatin rich in transposable elements. www.biorxiv.org/content/10.1...

submitted 95 days ago • 3 comments

Asking your manager or mentor for constructive feedback can feel intimidating, but especially in academia where we don’t have annual reviews, intentionally seeking it out is an enormously powerful practice! 👏 @ Kisha Greer (Science)

submitted 96 days ago • 0 comments

Did y’all see that Beaver Moon last night?! Awesome show from the lab

submitted 99 days ago • 0 comments

New work from Joan Brugge's lab @harvardcellbio.bsky.social explores how Brca1 haploinsufficiency promotes early tumor onset and epigenetic alterations in a mouse model of hereditary breast cancer - Led by Carman Li www.nature.com/articles/s41...

submitted 104 days ago • 1 comment

FINALLY!! Let’s give it a whirl…. AI protein-prediction tool AlphaFold3 is now open source www.nature.com/articles/d41...

submitted 104 days ago • 0 comments

Wow!!! IDO1 inhibition rescues LTP in both Tau and AB models of Alzheimers Disease Not my field but a very surprising and exciting result! Beautiful dissection of the phenotype and the biological mechanisms! #neurodegenerativeDeisease #science #drugTargets

submitted 173 days ago • 1 comment

Great talk today by Alec Kimmelman today at DFCI - enjoyed learning about the supportive role of tumor innervating neurons in PDAC and the metastatic tumor microenvironment! 🧬

submitted 284 days ago • 0 comments

Another giant virus with histones y'all. Medusavirus has them all, and even linker histone (maybe?). Check out our latest preprint by the amazing Chelsea Toner and @nhoitsma.bsky.social biorxiv.org/cgi/content/...

submitted 314 days ago • 0 comments

Super interesting!! 🧬 Epigenetic states favored by the organ of residence can influence the function of driver genes in metastatic tumors www.biorxiv.org/content/10.1...

submitted 341 days ago • 0 comments

Super cool!!! Cell-proximity labeling in vivo #immunology #systemsbiology 🧬 www.nature.com/articles/s41...

submitted 352 days ago • 0 comments

The @fda.gov CBER updated their CAR T cell product guidance - enhanced focus on acute toxicities and long term follow up 🧬 #genomicMedicines #drugDevelopment #biotech

submitted 353 days ago • 0 comments

No well-dressed penguins allowed!

submitted 354 days ago • 0 comments

Highlighting the importance of use of informative initialization in low-dimensional projection of single cell seq data, Kobak and Linderman explain why Laplacian eigenmaps should be default behavior of both UMAP and t-SNE. Great quick read! 🧬 www.nature.com/articles/s41...

submitted 364 days ago • 0 comments

Funny to see this article about negative consequences of excess leucine in high protein diets www.nature.com/articles/s42... come out on the same day I woke up to an @npr.org story about the importance of getting enough protein in one’s diet www.npr.org/sections/hea...

submitted 370 days ago • 1 comment