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alessiociulli.bsky.social
Professor, Founder and Director of the Centre for Targeted Protein Degradation at the University of Dundee. We develop molecules that induce protein interactions and degradation
27 posts 524 followers 186 following
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Delighted to see this, many congratulations and fully deserved! The Boehringer foundation and your colleagues are lucky to have your vision leading this initiative. I am excited as our collaboration will thrive in your new home, and by opportunities for AITHYRA and CeTPD to work together in future

submitted 9 days ago • 0 comments

Something that qualifies as big news from my side: I am very happy and excited to announce that I have been appointed as Life Science Director at AITHYRA, a new Research Institute for Biomedical Artificial Intelligence. Find out more in the link and 🧵 below lnkd.in/d_HaGuSE

submitted 11 days ago • 3 comments

Check-out the first paper from @farnabygroup.bsky.social developing novel chemistry for plate-based PROTAC assembly that in a single Direct-to-Biology (D2B) screen delivers a potent hit that degrades the target protein in the brain of a mouse. Delighted to see this out and kudos to all co-authors

submitted 14 days ago • 1 comment

Congratulations to our Keystone Proximity-Based Therapeutics conference travel scholarship winners Christine Ng @stanford-chemh.bsky.social and @alesalerno.bsky.social at CeTPD Dundee! @keystonesymposia.bsky.social

submitted 30 days ago • 1 comment

Congratulations to @alesalerno.bsky.social from University of Dundee CeTPD and Christine Ng from @stanford-chemh.bsky.social who have been selected as recipients of our conference travel scholarships to attend the Proximity-based Therapeutics Keystone conference @keystonesymposia.bsky.social!

submitted 59 days ago • 0 comments

Collaboration with @supertifurgalab.bsky.social out in @cp-cellchembiol.bsky.social we identify a role of ABCC1 transporter in PROTAC efflux. It turns out, getting in is surprisingly not often the problem; it’s keeping it once inside the cell! Maybe some wider lessons. Designing it out could be key

submitted 75 days ago • 1 comment

The best way to start 2025: New Year, New Paper! Happy to see (finally!) the science of Amphista therapeutics coming out on @biorxivpreprint.bsky.social Work led by @andre-head.bsky.social and Scott Hughes and congrats to the entire Amphista team involved on the drug development and mode of action.

submitted 81 days ago • 0 comments

It was such a fun experience exploring the endless possibilities that unconventional ideas (and chemotypes!) can bring to life! 💡 Huge kudos to everyone who was part of this exciting project! 💫🧪

submitted 92 days ago • 0 comments

🚨 Exciting News! 🚨 What happens when unconventional ideas drive to push boundaries? 🚀 Meet FerroTACs: a novel #PROTAC design using ferrocene as core unit to re-imagining linker design and fine-tune their phys-chem properties. Learn more about our work led by @alesalerno.bsky.social here: 🧪👇 1/5

submitted 92 days ago • 3 comments

Happy to share our latest review on SOCS proteins and their role and therapeutic potential as targets in immunology. To date, drug discovery targeting SOCS proteins have been elusive, due to the difficulty to drug their polar SH2 domain.. 1/3 www.frontiersin.org/journals/imm...

submitted 106 days ago • 1 comment

That awkward moment when someone publishes a paper saying that they can’t find any evidence that your compounds bind to what your own series of papers say that they bind to. . .

submitted 111 days ago • 9 comments

So privileged that CHI-Healthtech brought their flagship #DDC conference to Europe, in sunny ☀️ Barcelona! Enjoying tapas and sangria with Heide Düvel @chemb.bsky.social @rpnowak.bsky.social Gopal Sapkota, Ed Tate @nurkocaturk.bsky.social Hannah Peters, Rima Alawar. Thanks for the invitation Tanuja!

submitted 111 days ago • 1 comment

Nice write-up of the successful SMART TPD symposium in Shenzhen, China - co-organised with Nat Gray, Nieng Yan, Peng Chan and Shixiang Yan. So enjoyed the opportunity. #TPD #SMARTsymposia www.szbl.ac.cn/en/infomatio...

submitted 111 days ago • 1 comment

Just announced: 2025 Computer-Aided Drug Design (CADD) GRC program The topic: "Exploring the Synergy of Machine Learning and Physics-Based Computational Chemistry to Accelerate Drug Discovery" It is shaping up to be a seminal conference. Hope to see you there! www.grc.org/computer-aid...

submitted 118 days ago • 2 comments

Sooo hilarious yet true!! 😂🤣

submitted 113 days ago • 0 comments

Leveraging Dual-Ligase Recruitment to Enhance Protein Degradation via a Heterotrivalent Proteolysis Targeting Chimera | Collaboration with @georgwinter.bsky.social and Kristin Riching labs. Now published in Journal of the American Chemical Society @acsjacs.bsky.social pubs.acs.org/doi/10.1021/...

submitted 114 days ago • 2 comments

Dual-ligase PROTACs: a novel approach for enhancing TPD. By recruiting two distinct E3 ligases within a single molecule, we amplify degradation efficacy & potentially mitigate resistance occurrence. Great collabo with the Ciulli lab & friends at Promega. pubs.acs.org/doi/10.1021/...

submitted 116 days ago • 1 comment

So proud of my former PhD student Tom Webb who defended his thesis with flying colors yesterday! Many thanks to @robvanmontfort.bsky.social from the ICR and Beatriz Baragana from our own Dundee DDU. Also great to host Johan Johansson from AZ it was great to have you visiting us!

submitted 117 days ago • 1 comment

Hi everyone! I’m excited to joining this community at @bsky.app BlueSky Social and temperature-test this over the next few months! Looking forward to connecting and sharing with many of you here!

submitted 117 days ago • 0 comments