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alexhematologist.bsky.social
Haematology Consultant Interested in CML, MPN's and lymphomas
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‼️ #ASCO25 simultaneous publication by Dr. Mazyar Shadman et al.:  Zanubrutinib and Venetoclax for Patients With Treatment-Naïve Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma With and Without Del(17p)/TP53 Mutation: SEQUOIA Arm D Results: brnw.ch/21wT3Ph

Why do some people with the Duffy null phenotype have an ANC below most institutional reference ranges? Explore the mechanism behind this phenomenon 👇 Learn more: www.hematology.org/e... #DuffyNull #HemeSky #MedSky #DANC #ASHEducation @ash.edu.hematology.org

Chronic myeloid leukemia is a myeloproliferative neoplasm. This Review summarizes the epidemiology, diagnosis, and management of chronic myeloid leukemia. https://ja.ma/4mlR6ez

Great results. Now we need a trial in acquired TTP, ideally a PLEX free combo (steroids, caplacizumab, rADAMTS +- Ritux)

Tens of thousands of people are taking part in a pro-Palestine protest in Dublin calling for an immediate ceasefire in Gaza.

oh boy...

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Venetoclax plus modified intensive chemotherapy (CAVEAT) is well tolerated and effective (75% remission) in fit, older patients with AML. buff.ly/yYKRjn5 #hemesky #clinicaltrialsandobservations #myeloidneoplasia

Yet another target for potential PD-1 inhibition! Guess which drug patent expires next year in Europe 😁🔥

Myeloid neoplasms may arise after prior cytotoxic chemotherapy and/or large-field radiation therapy, commonly associated with TP53 mutations, and complex karyotype with frequent 5q/7q/17p loss. buff.ly/CnosfH9 #hemesky #bloodwork

Now this is a fucking station!!! Naples underground station, with its remarkable timber arches, by EMBT

ClpP inhibition reveals a dual role in multiple myeloma, weakening cancer cells and activating anti-tumor immunity. by Perini T, Zordan P (...) Cenci S et 20 al. in Blood #MedSky 👉 get more here 📖 read the article:

Functional hematopoietic stem cells with unique gene signatures reside in the adult human lung. buff.ly/dlKQKD5 #hemesky #hematopoiesisandstemcells

Social housing for over 65’s in Mallorca by H Arquitectes Load bearing walls with reclaimed stone aggregates (mined from demolition debris), and CLT floor slabs Super low embodied carbon of 417kg of CO2/m2 and €1,600/m2 build cost (including demolition)

Yeah, nah

Oligocentric CD is an intermediate phenotype distinctly characterized from unicentric and iMCD. buff.ly/zOHYxKF #hemesky #clinicaltrialsandobservations

Imo Iranian architects are world-leading in modern apartment aesthetics and functionality

There’s lots to learn from Iranian mid-rise housing! 6-storey apartments in Isfahan, Iran, by Soo Architects - The right balance of windows + shade - Recessed balconies - Simple, but beautifully detailed

youtu.be/wFJ3PZuAjK4?... First good thing to come in 2025. Goosebumps!! 🔥🔥🔥

🩸🧪Different Color Blood Tubes and What They’re For🧪🩸 each color has a different additive, and a different purpose! a thread for #LabWeek 🧵 1/x

Cabbie-bara. #art #capybara #taxi

GCB-DLBCLs depend on DOT1L and EZH2, and combined targeting provides an alternative differentiation-based therapy. buff.ly/y4dYWv9 #hemesky #lymphoidneoplasia

Sweet! (literally) www.embopress.org/doi/full/10....

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