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alexisrohou.bsky.social
CryoEM and structural biology methods, drug discovery. Also: Celtics, Camus, rocksteady, drum and bass. He, him, his.
585 posts 1,444 followers 220 following
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Dear California Representatives: Your leadership is more important than ever! We believe in your ability to make a difference—how can we support you in bringing more attention to this critical issue? @repscottpeters.bsky.social @levin.house.gov @schiff.senate.gov @padilla.senate.gov. Pls Repost!

BIG news: Jason Chin is leaving the Division of Protein & Nucleic Acid Chemistry of @mrclmb.bsky.social to spend yet another billionaire's ££ in Oxford. This will create a gap that will need filling! So, if you're thinking of making a move, now is the time to reach out! www.eit.org/news/profess...

💥The Netherlands' largest pension fund, has sold its shares in Tesla, Meta, and Alphabet (Google). The fund with US $569 billion equivolent in assets is "directing more money to companies and projects that help to improve society and the environment." #Divest www.reuters.com/markets/euro...

Open source software for the win. Generating plausible structural ensembles in a highly efficient manner could be very useful!

“the United States is not a startup. The federal government exists to do all of the things that are definitionally not profitable, that serve the public good rather than protect investor profits. (The vast majority of startups also fail, something the United States cannot afford to do.)”

A good analysis of the current economic success by integrating new neighbours (which is accompanied at the same time by great improvement in many social issues, although some more are needed) 👇 www.theguardian.com/world/2025/f...

Just wonderful writing on the 60 Minutes piece on President aMusk dismantling of USAID "The world's richest man cut off aid for the world's poorest people." Well done.

He has hollowed out the meaning of ‘saving your country’ and replaced it with something like ‘demolish those who disagree with me’. If he or anyone even tried to make the case that they really are trying to save the country (and from what), the whole thing would fall apart.

“When you dismiss children dying as a direct result of your actions as a “media narrative,” that is a good sign that you are an undiagnosed sociopath.”

The measles outbreak in Texas is reminding me of the public letter Roald Dahl wrote about losing his daughter to measles in 1962, just before the vaccine was publicly available.

Cultural revolution in the US. Elevation of ignorance and empowerment of the ignoramus. Large scale, capricious upheaval of core government functions. This is likely to lead to illness, hunger and poverty for many.

“The richest man in the world, Elon Musk, is stealing money from you to put in his pocket” has to be the easiest political argument ever www.nytimes.com/2025/02/12/u...

This is what actual corruption looks like

Excited to share PoET-2, our next breakthrough in protein language modeling. It represents a fundamental shift in how AI learns from evolutionary sequences. 🧵 1/13

What I find wild about this episode is how much the story telling about the woes of science and incentives align with narratives behind shutting down science funding. “Unethical scientists in a broken system are wasteful and creating wrong and useless results” podcasts.apple.com/us/podcast/f...

Happy 86th birthday Derrick Harriott. One of my all-time favorite singers and producers. #reggae #rocksteady

1. Today the NIH director issued a new directive slashing overhead rates to 15%. I want to provide some context on what that means and why it matters. grants.nih.gov/grants/guide...

Excited to see work led by @autophazeke.bsky.social, @minghaochen.bsky.social, Thanh Nguyen, and Ainara Claveras out in @science.org today, the culmination of a 15-year project to understand structurally how the synthesis of the critical lipid of autophagy, PI3P, is regulated. tinyurl.com/ywvjh8u4

I now think “state capture” (a concept new to me, I confess) might be a better description of what is happening. Not quite a coup in the traditional sense. More like corruption on steroids with surrender of the common good to oligarchs.

This thread articulates why I am so worried about these actions by acolytes of Elon’s. I don’t think per se they constitute a coup. But they could enable one. And they will almost certainly enable more illegal coercion of individuals, organizations and maybe even states.

I want to spell out the basic reason it’s so dangerous for Elon to have control of the U.S. payments system. It may seem like a technical matter, but the dynamics are simple. 1/x

Compared with any other major country, the United States has been extremely fortunate in its two immediate neighbors, Canada and Mexico. Now, incredibly, it is declaring economic war on both of them. This is a war no one can win, and from which tens of millions will lose. This is insanity.

"We have fought and died alongside you....During your darkest hours...we were always there. Standing with you, grieving with you, the American people.” I’ve had my differences with Justin Trudeau, for sure, but he rose to the occasion here.

As Trump cites fentanyl as a reason for 25% tariffs on our allies, a reminder that after taking office he ORDERED LAW ENFORCEMENT TO STOP INVESTIGATING DRUG TRAFFICKERS so he could divert resources to prosecuting immigrants instead. He's making our communities poorer and less safe.

Having watched with growing alarm the developments of the last 24 and 36 hours in Washington, I thought I’d take a stab at how the US media would cover this story if it was happening in a foreign country. Here’s that story that should be written this weekend: www.doomsdayscenario.co/p/musk-s-jun...

This is going to be a lot of fun! Join us at the ASPET meeting in April! events.rdmobile.com/Sessions/Det... @alexisrohou.bsky.social @stephanieaw.bsky.social

This story is bananas. "A team including current and former employees of Musk assumed command of OPM on Jan. 20 ... They have moved sofa beds onto the fifth floor of the agency's headquarters, which contains the director's office and can only be accessed with a security badge or a security escort."

My first science post here on BlueSky is a long one. Setting the contrarian tone from the very beginning, I take strong issue with the recent op-ed by Charles Piller published in the January 24th NY Times on #Alzheimer's disease (nam12.safelinks.protection.outlook.com?url=https%3A...)

“small government” in action.

As someone who has reported on AI for 7 years and covered China tech as well, I think the biggest lesson to be drawn from DeepSeek is the huge cracks it illustrates with the current dominant paradigm of AI development. A long thread. 1/

It’s remarkable that this progress is open source. This should increase our valuation of most LLM-leveraging outfits worldwide and bring about optimism in the field, not the opposite. Though I can see why large, less nimble companies would take a hit. Much more challenging for them to adapt quickly.

As scientists going through difficult times, I think it’s important to remember the things that bind us together: 1) Our love of free food. 2) Our inability to explain what we do to our families. 3) Our hatred for Reviewer #3. Now please go do fun things this weekend and hang out with nice people.

My colleague Xiao Tao is recruiting a postdoctoral fellow to work at Genentech on membrane protein structure & function, in close collaboration with our #cryoEM team. If you love membrane proteins and playing with the latest tech, please consider this opportunity!

This is an impressive paper. Capturing multimeric receptors in their native state is both important and highly challenging, and this study represents another triumph of cryo-EM www.nature.com/articles/s41...

For the attention of the @royalsociety.org, in case they thought there was wiggle room.

Memory engram synapse 3D molecular architecture visualized by cryoCLEM-guided cryoET pubmed.ncbi.nlm.nih.gov/39829918/