alf-castello.bsky.social - Profile | ThreadSky | a Reddit-style client for Bluesky

I am really pleased we managed to squeeze this story out during #ASMS2025. This is our contribution relating to the fantastic Omnitrap/Orbitrap. What we thought would be a straightforward conversation of our exploris-omnitrap turned into quite a journey. (1/n) www.biorxiv.org/cgi/content/...

submitted 19 days ago • 1 comment

🚨🚨 News from the @castello-lab.bsky.social and @shabazlab.bsky.social. Our work, led by Louisa Iselin, reveals pervasive changes in the RNA-bound proteome induced by interferon. #RNA, #immunity, #interferon, #host-virus www.biorxiv.org/content/10.1...

submitted 16 days ago • 1 comment

Proud of Louisa Iselin for this work. Not only a covid baby but had both of her supervisors move lab (@alf-castello.bsky.social and me). The works is a meticulous analysis of the interferon pathway and specifially how RNA binding of proteins are modulated by PTMs. www.biorxiv.org/content/10.1...

submitted 18 days ago • 0 comments

Happy to see Honglin Chen's paper published! 🎉🎉🍾🥂. Great collaboration with @shabazlab.bsky.social to discover the discordances between RNA and protein in the interferon response...

submitted 73 days ago • 0 comments

A basic solution to a very common problem. collab with @kusterlab.bsky.social and @bendavisgroup.bsky.social www.mcponline.org/article/S153...

submitted 99 days ago • 2 comments

Great conference at @embl.org on the expanding world of #RBPs. After the hard (fun) work, the @castello-lab.bsky.social chilled out in the beautiful Heidelberg

submitted 97 days ago • 0 comments

Pre-print is up! SARS-2 produces a truncated N protein to antagonize multiple antiviral pathways. A very collaborative project in the @corcoranlab.bsky.social with @nogasharlin.bsky.social, Danyel Evseev, and Max Bui-Marinos, and of course the boss Jenn Corcoran www.biorxiv.org/content/10.1...

submitted 110 days ago • 0 comments

@science.org Cryo-EM reveals mechanisms of natural RNA multivalency | Science www.science.org/doi/10.1126/... #RNAsky #RNAbiology #Cryo-EM

submitted 99 days ago • 2 comments

Excellent talk of Louisa Iselin on the remodelling of the RBPome by interferon at the "Expanding Universe of RBPs" in @embl.org, Heidelberg. The @castello-lab.bsky.social is very proud 🍾🥂🎊🎊

submitted 100 days ago • 0 comments

Translation of mRNA can be triggered with spatiotemporal control in zebrafish 🐟 embryos by light ⚡ & FlashCaps 🧪⚗😊 Kudos to all authors and collaborators 🙏👍 www.nature.com/articles/s42...

submitted 143 days ago • 4 comments

Amazing work of our dear friends @ilandavis.bsky.social and @jeffylee.bsky.social characterising the interlinked roles of two key RBPs in drosophila brain development, congratulations 🍾🥂🎉🎉🎉 www.science.org/doi/10.1126/...

submitted 123 days ago • 1 comment

Had a wonderful couple of days with these guys. @alf-castello.bsky.social @marvintanenbaum.bsky.social and Stephen carter. Always a pleasure

submitted 148 days ago • 0 comments

At this END of YEAR please check out our new paper on GENE ENDS and a convenient marker of transcription termination: RNAPII CTD T4ph! We think it is relevant to anyone studying human/animal #genes and #genome so put a lot of effort to make it easy to read. #RNABiology and #Epigenetics meet:)

submitted 175 days ago • 1 comment

These studies are so important. Well done to the authors and the journal for publishing it. This certainly applies to so many antibodies. Companies selling antibodies should do and provide the right controls before commercialisation. www.nature.com/articles/s41...

submitted 177 days ago • 4 comments

Please check out our paper in collaboration with Nahum Sonenberg's group. We show how some DNA viruses co-opt the host cell translation machinery to repress the cGAS/STING response. TLDR; the cap-binding protein 4EHP represses the cGAS mRNA translation. #RNA, #RNASky www.pnas.org/doi/10.1073/...

submitted 212 days ago • 0 comments

RECRUITING-PhD student to study the role of RNA-binding proteins in antiviral defence during early development. #crispr #iclip #omics Interested candidates, please email a full CV and a statement of interest. Open to both UK and overseas www.findaphd.com/phds/project...

submitted 200 days ago • 0 comments

Nuclear RBPs moonlighting in the cytoplasm as part of the host response to Sindbis virus. Another beautiful work by Alfredo Castelo’s group. I’m struggling to keep up with reading all the amazing papers they’ve published in the last few months. www.cell.com/molecular-ce...

submitted 196 days ago • 1 comment

I am just going to plug-in the latest paper from our lab, wherein we show that treatment with the chemotherapy agent 5-Fluorouracil (5-FU) induces ribosome collision and that RQC pathway mitigates the 5FU-induced cytotoxicity. #RNA, #RNASky, #Cancer academic.oup.com/nar/article/...

submitted 213 days ago • 0 comments

A deserved celebration after the hard work 🍾🥂. @waelskamel.bsky.social and collaborators from the @castello-lab.bsky.social discovered that the U2 snRNP displays a moonlighting antiviral role and uses the U2 snRNA to interact with viral RNA 🤯🤯🤯 t.co/DJlXFxmGEv

submitted 185 days ago • 1 comment

🎄Amazing @castello-lab.bsky.social Christmas lunch! Great food, fantastic company, and lots of fun. We even created some art masterpieces during our pottery painting session afterwards 🥳. #Lablife, #Christmasfun, #RNA, #virus

submitted 185 days ago • 0 comments

🦸 Hidden superheroes in our cells!? @waelskamel.bsky.social, @castello-lab.bsky.social & the Rosalind Franklin Institute have uncovered how a team of cellular “superheroes” leap into action to stop viruses in their tracks. More: gla.ac.uk/research/az/... The study: cell.com/molecular-ce...

submitted 190 days ago • 0 comments

Cool

submitted 193 days ago • 0 comments

Big news! We're looking for a new Professor (or Associate Professor) in Infection and/or Immunity! Come work with us in @cambridgebiosci.bsky.social, it's a collaborative and supportive environment with great resources, students and colleagues! www.jobs.cam.ac.uk/job/49381/ Deadline 26/1/25 (Pls RT)

submitted 203 days ago • 1 comment

Really important achievement.. Price to the most original lab costume for the @castello-lab.bsky.social in the @cvrinfo.bsky.social Christmas party. Inspired by the notes of the "Sound of Music"😁. 🍾🥂🏆

submitted 194 days ago • 2 comments

I am delighted that our long standing close collaboration with AlfredoCastello lab has led to yet another very exciting publication in Mol Cell: thanks so much to Wael and Alfredo for taking the lead. www.cell.com/molecular-ce...

submitted 195 days ago • 1 comment

I am now joining this platform. Nice to meet the #RNA and #virus community here

submitted 195 days ago • 0 comments