alforrest.bsky.social - Profile | ThreadSky | a Reddit-style client for Bluesky

Heading to #lornegenome25 #LorneCancerConference ? Looking for a computational postdoc to work on spatial and single nuclei transcriptomics of poor prognosis cancers, please DM me or see me at Lorne. We will be advertising soon. @ozsinglecell.bsky.social #LorneCancer2025 #Lorne2025

submitted 20 days ago • 1 comment

@ozsinglecell.bsky.social #OzSingleCell25 has a new website www.ozsinglecell.com See the current list of invited speakers and stay tuned for registration details. Sponsors reach out to [email protected]

submitted 33 days ago • 0 comments

A little video intro into Illumina Single Cell 3' RNA Prep protocols. It has begun!! #singlecell #transcriptomics #PIPSeq #illumina

submitted 50 days ago • 1 comment

Out today in @naturegenet.bsky.social -- PERFF-seq! With @tsionabay.bsky.social , @ronanchaligne.bsky.social, Bob Stickels, Meril Takizawa, + Ansu Satpathy, we describe this new assay to study rare populations with programmable nucleic acid cytometry. 1/n www.nature.com/articles/s41...

submitted 55 days ago • 4 comments

@nature.com wants to hear from you on the battle of David vs Goliath - aka Twitter 🐥 vs Bluesky 🦋* And if you’re reading this post I already know your answer to one of the questions 🙂‍↕️ 👉🏼 www.nature.com/articles/d41... *I’ll let you decide who’s who at this point!

submitted 48 days ago • 0 comments

www.cell.com/cell/fulltex... Perturb-map - focused on receptor/ligands hypothesized to be involved in tumor-macrophage communication

submitted 53 days ago • 0 comments

I've been catching up on some reading and came across this paper. Ovarian cancers export a cancer-specific #lncRNA, Tu-stroma, to TME via exosomes. Tu-stroma alters spicing of flower gene in stromal cells to reduce cell fitness. Such a cool mechanism.

submitted 53 days ago • 0 comments

Sridevi Challa, Lee Kraus et al. discover a druggable PARP14/TARG1-regulated pathway that mediates site-specific mono(ADP-ribosyl)ation of the ribosomal protein RACK1 & modulates the growth of ovarian #cancer cells. https://buff.ly/3DOejo4

submitted 54 days ago • 0 comments

AI-driven ultrasound detection of ovarian cancer. #NatureMedicine "AI model ROC curve and human examiner performance" Open Access www.nature.com/articles/s41...

submitted 58 days ago • 3 comments

Very excited to announce that the single cell/nuc. RNA/ATAC/multi-ome resource from ENCODE4 is now officially public. This includes raw data, processed data, annotations and pseudobulk products. Covers many human & mouse tissues. 1/ www.encodeproject.org/single-cell/...

submitted 55 days ago • 6 comments

We are here 🦋. Save the date for Oz Single Cell 2025, 23-25 May in Sydney

submitted 56 days ago • 0 comments

Wow head-to-head comparison Visium HD FFPE, CosMx 6K, Xenium 5K, Stereo-seq v1.3 and Visium HD FF profiling on HGSOC and HCC. Heads-up @GESTALT_sp hopefully can save community some $$$$

submitted 64 days ago • 0 comments

Our paper with @NCARD_research is finally out. Finds • Circulating CD8+ TEMs are more abundant in chemoimmunotherapy responders • Stem-like CD8+ TEM expansion links to permissive pre-treatment tumour environment cell.com/cell-reports... #mesothelioma

submitted 66 days ago • 0 comments

Another terrible year for #NHMRC Ideas grants in WA. Only 6 of 127 submissions funded. National rate was 10.1%. If this was an equitable funding scheme WA should have got 12 or 13. Multiple category 6 grants missed out. This means 6 or 7 of the best research groups in WA give up.

submitted 77 days ago • 3 comments

I need a volunteer..

submitted 78 days ago • 0 comments

Is biorxiv down/slow today?

submitted 85 days ago • 1 comment

I never tire of seeing these progressively improved pediatric ALL survival curves, which represent one of the most remarkable achievements in all of medicine. Amazing to see even more improvement with bispecific antibody #immunotherapy presented in the #ASH24 Plenary session. #hematology #leukemia

submitted 85 days ago • 2 comments

Major milestone: Tabula Sapiens 2.0 maps tissue composition & TF expression in 175 cell types, identifying 745 ubiquitous & 890 cell type-specific TFs (many still uncharacterized -> #Codebook) w/ roles in tissue homeostasis, stress response & metabolism. #SingleCell www.biorxiv.org/content/10.1...

submitted 86 days ago • 0 comments

El otro día, un guionista en edad de jubilarse me contó que su mujer le había reñido: “Siempre igual, con mil proyectos a la vez, y diciendo que vas a aflojar cuando no te lo crees ni tú”. Sentí vértigo: ¿serán así mis próximos 25 años? Con suerte. Si alguien encuentra un equilibrio, que avise.

submitted 89 days ago • 3 comments

In Hong Kong for #HCAAsia 2024. Looking forward to catching up with colleagues and discussing collaborations in the region.

submitted 92 days ago • 0 comments

NHMRC Ideas grants are out under embargo. Congrats to those who got theirs.

submitted 98 days ago • 1 comment

Great story www.nature.com/articles/d41...

submitted 98 days ago • 0 comments

The Australia New Zealand Gynaecological Oncology Group, #ANZGOG, Annual Scientific Meeting will be held in Canberra, Australia, March 5-7, 2025. Abstracts currently due by Dec 2nd. www.anzgogasm.org.au #GynaecologicalCancer #OvarianCancer #EndometrialCancer #BasicScience #ClinicalTrials

submitted 99 days ago • 0 comments

1/ Introducing SCimilarity, a new foundation model to explore single-cell RNA-seq data across tissues and diseases! It learns a common measure of cell similarity by training a deep metric learning model on millions of cells from various human tissues and conditions. www.nature.com/articles/s41...

submitted 101 days ago • 2 comments

Open-rank tenure track positions in computational biology! Come work with a gaggle of great colleagues in the CMSE department at Michigan State! #msu #cmse #compbio #bioinformatics #genomics #BioSky careers.msu.edu/cw/en-us/job...

submitted 102 days ago • 1 comment

Encouraging data for a neoantigen vaccine vs triple-negative breast cancer, revving up the immune system with favorable outcomes compared with historic controls (Phase 1 trial) genomemedicine.biomedcentral.com/articles/10....

submitted 110 days ago • 2 comments

Comprehensive benchmarking of tools for nanopore-based detection of DNA methylation https://www.biorxiv.org/content/10.1101/2024.11.09.622763v1

submitted 103 days ago • 0 comments

One enhancer can activate two endogenous genes simultaneously and across a TAD Boundary. Check out our new preprint. www.biorxiv.org/content/10.1...

submitted 119 days ago • 1 comment

Repurposing large-format microarrays for scalable spatial transcriptomics #spatial #newtech www.nature.com/articles/s41...

submitted 104 days ago • 0 comments

Spatially Resolved in vivo CRISPR Screen Sequencing via Perturb-DBiT https://www.biorxiv.org/content/10.1101/2024.11.18.624106v1

submitted 104 days ago • 0 comments

We ask students to write a research proposal, but we should also teach them about how the project will likely actually unfold.

submitted 105 days ago • 2 comments

My first post on Blue Sky - moving over ! For all post-docs out there - fantastic opportunity @EMBL. Independent group leader position: Core funding, state-of-the-art core facilities, access to fantastic Ph.D. students, and of course amazing colleagues. Please apply www.embl.org/jobs/positio...

submitted 105 days ago • 3 comments

This is funny www.theguardian.com/commentisfre...

submitted 108 days ago • 19 comments

More evidence of immune cell (macrophage) -> stromal cell (fibroblast) inflammatory communication to alter organ function (deleteriously, in this case) #ImmunoSky www.nature.com/artic...

submitted 109 days ago • 0 comments

Bilbo, to Gandalf, in Fellowship of the Ring: “I feel thin... sort of stretched, like butter scraped over too much bread.” I am feeling that right now watching the news.

submitted 109 days ago • 9 comments

It’s nice to see a flood of #genomics people moving on over to this platform.

submitted 109 days ago • 0 comments