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amarsahay.bsky.social
Professor @ MGH & Harvard Medical School. Hippocampus + Cognition. www.sahaylab.com Engineering strategies to restore, maintain and enhance cognition since 2011. Marathoner. Shark diver. Husband. Dad of human and wirehaired doxies
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Neuronal polyunsaturated fatty acids are protective in ALS/FTD @NatureNeuro www.nature.com/articles/s41...

This is a big one. "Alzheon will present the topline results of the pivotal APOLLOE4 Phase 3 trial at a dedicated symposium titled “Inhibition of Beta Amyloid Oligomer Neurotoxicity with Oral Valiltramiprosate in APOE ε4/ε4 Homozygotes with Early Alzheimer’s Disease: April 1st. ADPD".

“Our full potential is on the other side of fear.”

Great guidelines for institutions: By now, many organizational leaders are well aware of the need to conduct a legal review of their DEI programs.But having lawful policies in place is one part of the equation.The way you communicate about those policies matters just as much. hbr.org/2025/02/the-...

The oral drug used in this study, called Risdiplam, manufactured by biotech firm Roche, based in Basel, Switzerland, is a small molecule that works by modifying expression of the SMN2 gene so that it produces more SMN protein.

www.thefp.com/p/the-intern... “It epitomizes everything that’s wrong with our current media environment. Unreliable or phony information, and the internet mobs they feed, spreads fast. But it feels impossible to keep up or correct the record—even when the black-letter facts are on your side.“

🚨📃New Wassum Lab Paper📃🚨 Out today, @jackiegio.bsky.social discovered brain pathways that support agency and habit and how chronic stress disrupts them to rob of us our agency and cause us to form rigid habits 🧵👇 www.nature.com/articles/s41... Free full text: rdcu.be/eaxEv

ATTENTION (PLEASE SHARE) If anyone has or knows of any positions that might be appropriate for the NIH staff members who were terminated, please post the information in this thread. There are lots of talented and accomplished people who may be looking for new opportunities.

www.nature.com/articles/s41...

It’s been a tough few weeks. My 10yo daughter was diagnosed with a very rare, aggressive cancer called interdigitating dendritic cell sarcoma (IDCS). I’m reaching out to identify clinicians/patients who have encountered pediatric IDCS or other (non-LCH) dendritic or histiocytic sarcomas cases.

A Tiger fell into a well in India, most likely in pursuit of the wild-boar that fell in too. The two abandoned their ancient instincts of fight or flee, eat or be eaten, to co-operate, driven by will to survive, and be saved by local authorities. Truly amazing!!!

www.science.org/doi/10.1126/... AAV GT conferring Reversible inhibition with compact epigenetic editor.

www.cell.com/cell/fulltex...

Same beacon of welcome, but a different winter afternoon.

GM. Morning run.

It is with profound sadness that we share the devastating news that Eleanor Maguire passed away on January 4th. She was a phenomenally brilliant neuroscientist, with immense passion for her work and many remarkable accomplishments. We will miss her terribly. www.online-tribute.com/EleanorMaguire

“chABC treatment in PNN research ..cannot be claimed to be specific to PNNs.” The absence of WFA+ labeled PNNs had little to no impact on memory processing or the intrinsic physiological properties of PV+ interneurons in V1.“

VIP interneurons control hippocampal place cell remapping through transient disinhibition in novel environments. https://www.biorxiv.org/content/10.1101/2025.02.01.636072v1

Grin2a Dysfunction Impairs Cognitive Flexibility by Disrupting LC Modulation of mPFC Circuits https://www.biorxiv.org/content/10.1101/2025.02.01.636062v1

Glavin is most perplexed by the discovery of an equal mixture of left-handed and right-handed amino acids on Bennu. Now, researchers have to go back to the drawing board to understand how life might have been seeded on Earth. www.nature.com/articles/d41...

Non-opiate pain killer: www.nature.com/articles/d41...

The meandering path, the filtered morning light, the stubborn evergreens, the remnants of past snow.

Crazy. Felt minor earthquake just now in MA.

Bravo Sinner. Clinical decimation a la Borg.

Fantastic Madison!!!!! Truly awesome news.

GM. What a match. The GOAT’s genius includes duping Carlos into changing his game while sticking to his own game. Another trick by the Joker?. We will never know. Great job Novak!

Excited to share our Preprint led by talented PDFs, Yu-Tzu Shih PhD and Jason Alipio PhD describing our identification of Experience-dependent PV IN plasticity as a convergent mechanism for Neurodevelopmental Disorders (NDDs) 1/n www.researchsquare.com/article/rs-5...

Good morning hooted the snow owl as blades of light carved scrawny silhouettes in the frost.

Scientist position at The Hospital for Sick Children in Toronto. We are looking for neuroscientists with interests in the molecular and cellular bases of cognition. The position is open-rank, and the successful candidate will also be appointed at U Toronto. Deadline is Feb 15th. Come join us!

The “Ponder” Amaretto sour, Amaretto, Rye, lemon juice, egg white, Luxardo cherry and Beech wood smoke.

Savoring nature’s embrace on morning run and thinking of her wrath and those impacted in LA.

Zurzuvae showed rapid and remarkable effects in alleviating postpartum depression in new mothers.. Save this drug, it saves lives. endpts.com/biogen-offer...

A must read, a new chapter in the field of Adult Hippocampal Neurogenesis. Evidence for neoteny of dentate granule cells in the adult human dentate gyrus? Read on…

Sayonara Goa!

The toughest part was actually the mental part of being at the start line every day again," she said. The physical challenges also weren't easy. Dosogne did it all while working part-time and caring for a family of five. "I realized I needed much more sleep than usual," she said

“Forget about it. It turns out people were wrong. And peptides can be medicines, and they can even be produced also in a sustainable manner with fermentation, which is not a bad way of producing medicines”.