amartinezarias.bsky.social - Profile | ThreadSky | a Reddit-style client for Bluesky

The big problem with this notion of #VirtualCell www.cell.com/cell/fulltex... is the axiom that a cell is the outcome of the interactions between the genes it harbors. Any cell biologist will tell you that this is empirically wrong. #Cells are masters of their genes not the other way around.

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and hotel's that honour scientists by naming rooms after them Jacques Monod in #42 at Hotel Madrigal

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Love the feeling of the cafe's terraces in the balmy evening in #Paris #Montparnasse

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Thinking….

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Excellent work supporting #modularity of the mammalian #embryo, a role for #hypoxia & how development exploits these features. It shows what we can learn from assemblies of #gastruloids @ spatio-temporal coordination of the modules in AP organization. Putting modules together, extremely informative

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The modularity of the mammalian #embryo in display. Controlled assembly of classic #gastruloids and uncommitted precursors in #hypoxia, patterns the AP axis www.biorxiv.org/content/10.1... Beautiful & insightful from @bulutkarslioglu.bsky.social‬ group. Building models to learn and learning.

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Also, an interesting reflection from Bob Edwards on the contrast between Research Institutes and Universities. Having spent my academic life in the latter, I can relate. From "A matter of life" a first hand account of the path to IVF that I suggest as a read for those interested in human #DevBio

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"A matter of life" is discovery in Biology at its best. Here from “A Matter of Life”, Bob Edwards tells his impression when, together with J Purdy, they saw for the first time a human #blastocyst, The proximity of the thrill that comes with the moment of a real discovery. #MustRead #Oldham

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fond farewell to our DB colleague alex joyner, closing the 3rd stage of her storied career @mskcancercenter.bsky.social. she innovated genetic engineering in mice, illuminated the brain, advocated for women in science, and always lent an ear to those in need (eg, me). www.mskcc.org/news/looking...

submitted 19 days ago • 0 comments

Very important @nicolettapetridou.bsky.social‬ report #mechanochemical signalling control fate transitions www.biorxiv.org/content/10.1... w/ wide/significant implications. Perhaps the clearest indication so far of HOW #NotInTheGenes cell interactions mechanical pattern gene expression #MustRead

submitted 19 days ago • 2 comments

This is where the #GeneCentric view of nature and the monetization of polygenic risk scores lead. Not surprising but we need to counter informing and educating. This selection is not only futile (from statistical point of view) but just plane wrong and misleading scientifically.

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Headline here www.nature.com/articles/d41... should be “Iron deficiency in pregnant mice causes (SOME) XY embryos to develop with female characteristics. Interesting how aboyt 4/5% becomes a general statement. The observation clearly says iron deficiency alone DOES NOT cause the phenotypic change.

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Universities are not passive beneficiaries of government largesse. It is the federal government that depends on universities to conduct the research that keeps our nation healthy, safe and economically competitive.I discuss in the Washington Post. www.washingtonpost.com/opinions/202...

submitted 24 days ago • 2 comments

Do you want to join us to work in neurodevelopmental biology? Please apply 👇 #SEBD

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Colossal has sent us a statement, which we've added to the story. I don't feel the situation is any clearer...

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@jshendure.bsky.socialImpressive piece of work from ‪@jshendure.bsky.social‬ putting gastruloids to work and learning something from them about the clonal implications for #CellFate decisions of the heterogeneity of the starting PSC population www.biorxiv.org/content/10.1... #MustRead

submitted 34 days ago • 1 comment

1/2 James Till, from Till and McCullogh rightful claim, has passed away stemcellnetwork.ca/celebrating-... His achievements are the basis of a field and their prescient insights into the stochastic nature of cell fates. pubmed.ncbi.nlm.nih.gov/14104600/, commonplace today in the #StemCell field.

submitted 34 days ago • 1 comment

As someone who owes my graduate education, and all that followed in my life, to @UChicago, I find the progressive degradation of US universities extremely painful and feel for all the academics that find themselves in a barrage of the absurd, particularly @harvard.edu

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Excellent, clear and provocative discussion of the relationship between #Embryos and #EmbryoModels. Should they be regulated in the same manner? Is a replica a model? What teaches us more? #BioEthics @profEmmaCave shorturl.at/ruiB4

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Registration is now open! Gastrulation Reloaded: Developing, engineering & evolving the body plan 📅 October 14–17, 2025 📍 Paris, France 🗓️ Abstract & early bird deadline: July 15, 2025 www.gastrulation-reloaded.conferences-pasteur.org/home Exceptional lineup of speakers & many selected talks

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Jesus. Excellent work by Michael Le Page, and utterly infuriating scenario. As Michael points out, the press release from Colossal called these dire wolves throughout. But now they want to argue that they never claimed that. Scandalous, really. www.newscientist.com/article/2481...

submitted 36 days ago • 19 comments

In which we discuss the homologies between amphibian and mammalian organizers from the perspective of #gastruloids with special relevance to recently described A and C gastruloids as containing Spemann/Mangold and Trunk/Tail organizers www.sciencedirect.com/science/arti...

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It is indeed good to see how #gastruloids provide a fresh look at old and challenging questions of #DevBio and also, hopefully, paths to answers. Certainly to new experimental approaches.

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#Madrid I have so many memories, thoughts, literary references of old times that I miss in these foggy times.... #BPerezGaldos

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Klid před bouří / Calm before the storm @ceitec.eu @eu-life.bsky.social Community Meeting 2025

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Spring finally going strong in Sant Cugat del Valles

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3D human #amnion model. We are a veritable cellular lego cell.com/cell/fulltex... Very good piece of work, with a focus on the important aspect of this organ #physiology. @SantosLaB8 #CellsRUS #SCBM #EmbryoModels

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Not a bad view to work with

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Two transcriptional modules that control mammalian #gastrulation that are functionally linked through their GRNs www.biorxiv.org/content/10.1... and paced by interactions between Wnt and Nodal signalling Great collaboration with S Arnold and K McDole's labs #gastruloids

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🚨 Fully funded PhD with @atjcagan.bsky.social at @cambridgeuni.bsky.social Studying how somatic mutations and clonal expansions develop in living tissues to predict cancer risk early, using highly accurate next-generation sequencing. Apply now for Oct 2025 👉 www.jobs.cam.ac.uk/job/51281/

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Delighted to be included in Time magazine's #TIME100HEALTH list - a real illustration of the impact of preprints in biomedical science.

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“Science has no passport, no gender, no ethnicity, no political party.” EC President Ursula von der Leyen, announcing a €500M initiative to attract top global talent. In a fractured world, science remains a unifying force – rooted in diversity, driven by curiosity, and shared by all humanity.

submitted 52 days ago • 176 comments

Again, this is why, in addition to some C elegans, there is a lot from flies, frogs and chickens. I am a bit baffled by your comments but, as I say, if you want more model, descriptive textbooks, you do have some, Wolpert's is about Principles and importantly includes Plants.

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Of course and that is why many of them are in the print edition and others can be found on the on line resources.

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That is why many of them are in the print edition.

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An unfortunate decision. There's a lot of C. elegans in the print edition, just not a specific section for it. The online resources has more on it. The book is not about model systems but about principles of development. In any case, there are more classical textbooks and there is a choice.

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Just published the new edition of “Principles of Development’ from now called “Wolpert’s Principles of Development’ to honour his memory and the origin of this textbooks that aims at distilling the, sometimes elusive, principles underlying animal and plant development shorturl.at/LrOxn

submitted 54 days ago • 3 comments

In china a crane on a turtle holding a peach blossom is a sign, well wishes, of longevity and endurance and a balance between heaven (crane) and earth (turtle). A good present for….maturing people.

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Fossil #gastruloid found in China. I suspected the body plan they represent is old but....this old?

submitted 62 days ago • 1 comment