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amyloid-planet.bsky.social
Myeloma & Amyloidosis Specialist Karmanos Cancer Institute Detroit, Michigan
11 posts 379 followers 771 following
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Posts 12 Comments 3

Amyloid can be nearly invisible on fat pad biopsies without congo red stain. Note the non-specific whitish collagen signal when polarized compared to yellow-green amyloid colors. Texas red IF filter can be very helpful to differentiate background from real congo red staining. #pathsky #nephsky

submitted 64 days ago • 0 comments

Poster #ASH24: better improvements in pain & fatigue at D+90 post #mmsm CAR in underrepresented minorities. However, also notice 29% of minorities with worsening fatigue; subgroup analysis to better understand predictors of better vs worse fatigue. #MajorPROsASH

submitted 77 days ago • 0 comments

Pat LoRusso @yalecancer.bsky.social elegantly reviews what we need for dose optimization in drug development #SABCS24 @sabcs.bsky.social @oncoalert.bsky.social

submitted 77 days ago • 0 comments

Presented at #ASH24: Among patients with smoldering multiple myeloma at a high risk for progression, progression-free survival at 5 years was 63.1% with daratumumab monotherapy, as compared with 40.8% with active monitoring. Full AQUILA trial results: nej.md/3Zh3pOJ #MedSky

submitted 78 days ago • 0 comments

Impressive results for Anito-Cel new BCMA-targeted CART for #myeloma after median 4 prior lines of Rx. Proud that the #Karmanos Cancer Institute’s Dr Abhinav Deol was a co-investigator. This CART now in Phase 3 trial

submitted 78 days ago • 2 comments

BCMA/GPRC5D-dual targeting CART for relapsed #myeloma. The usual CART toxicity, decent response rates, and somehow no skin and/or nail changes. #ASH24

submitted 78 days ago • 0 comments

BCMA CART for smoldering #myeloma: high MRD(-) rates and no neurological DLTs (including late Parkinsonism) to date. Enjoy the honeymoon….and the IVIg? #ASH24

submitted 78 days ago • 0 comments

Predictably, after 5y of F/U the OS of cardiac stage 1-3a AL #amyloidosis is improved by adding Dara to CyBorD. This re-affirms prior landmark analyses showing depth of initial FLC response predicts subsequent survival. #ASH24

submitted 78 days ago • 0 comments

GLS >(-9) independently predictive of survival when added to criteria for AL stage 3b cardiac #amyloidosis: 3b + bad GLS = 3c In practice, may eventually identify pts who could particularly benefit from anti-fibril therapy

submitted 78 days ago • 0 comments

MRD negativity (with 10^(-5) threshold) in AL #amyloidosis doesn’t seem to predict overall survival or organ response….just TTNT (and median TTP?). Results a bit underwhelming, though the 300+ patient analysis was an impressive effort #ASH24

submitted 78 days ago • 0 comments

I’m not sure I’m done w X, but for now, I’m pretty “done” with X. Keeping it focused on myeloma, amyloidosis, hematology, and science here. Maybe comics, art, backpacking, and running. No politics. Will not abide random aggressive trolling. #mmsm #myeloma #amyloidosis

submitted 78 days ago • 0 comments

Any #myeloma or #mmsm or #nephrology or #hematology or #ASH24 “starter packs” of accounts to follow out there? Just signed up and looking for my peeps.

submitted 78 days ago • 2 comments