Profile avatar
andersshansen.bsky.social
Associate Professor at MIT BE : http://ashansenlab.com Interested in understanding the relationship between 3D genome structure and function
38 posts 1,912 followers 1,104 following
Regular Contributor
Active Commenter
Posts 24 Comments 26

1/n Excited to share our new preprint! Using live imaging in Drosophila embryos, we show that RNA Pol II clusters switch from sites of initiation to elongation during zygotic genome activation and that they are stably associated with an active gene: www.biorxiv.org/content/10.1...

submitted 14 days ago • 5 comments

JUST IN: A federal judge in Massachusetts has blocked the Trump administration's rate change to NIH grants. storage.courtlistener.com/recap/gov.us...

submitted 15 days ago • 74 comments

CTCF stall DNA 🧬 loop ➰ extrusion by cohesin - but exactly how it pulls this off is a 'mechanistic mystery' (to cite @andersshansen.bsky.social, Nucleus, 2020). We just preprinted 📜 a new study @biorxivpreprint.bsky.social that provides some answers to this enigma: www.biorxiv.org/content/10.1...

submitted 30 days ago • 5 comments

detailed update on where things stand at NIH as of now

submitted 34 days ago • 0 comments

Amazing and comprehensive new insights into arguably the single most important enzyme on the planet - RuBisCo - from @prywes.bsky.social

submitted 35 days ago • 0 comments

A one-way relationship or mutual influences? In our new review we discuss a few recent studies on the interplay between enhancer-promoter interactions and transcription. www.sciencedirect.com/science/arti...

submitted 36 days ago • 1 comment

Very exciting new paper from @romanbarth.bsky.social @ceesdekker.bsky.social : cohesin is a one-sided extruded but it can switch direction with help from NIPBL

submitted 41 days ago • 0 comments

Excited to share James Jusuf's preprint: By integrating Micro-C with SuperRes Live-Imaging we can calibrate genomics&imaging to perform absolute quantification of looping (e.g. this loop is present 3%) We quantify mESC 36k loops: <loops> are generally rare (2.3%) www.biorxiv.org/content/10.1...

submitted 41 days ago • 6 comments

Did you know CTCF has a life outside cohesin loop extrusion and 3D genome folding? Here is a short review of these molecular activities by Aaron Corin and with @vram142.bsky.social www.sciencedirect.com/science/arti...

submitted 67 days ago • 2 comments

Please check out our new paper showing that the supposed looping factor ZNF143 has no role in chromatin looping: www.cell.com/molecular-ce... And also check out the companion paper from @andersshansen.bsky.social: www.cell.com/molecular-ce...

submitted 68 days ago • 2 comments

We often speak about chromatin as being accessible or inaccessible, but what does it mean? We wrote a short review on this, 🔬 focused: sciencedirect.com/science/arti... A big thank you to Tom Fillot for his efforts on this and to @hansen_lab @marcelonollmann for their help as editors.

submitted 68 days ago • 4 comments

Excited to share @domenicnarducci.bsky.social 's paper now out in Mol Cell published back-to-back with the paper from @dewitlab.bsky.social‬ - despite lots of prior work, we find that ZNF143 has no looping function www.sciencedirect.com/science/arti... www.sciencedirect.com/science/arti...

submitted 68 days ago • 1 comment

👀SMC 🛵 on 🧬 induce 🥨 at each➰ www.science.org/doi/10.1126/... by @ceesdekker.bsky.social @romanbarth.bsky.social et al.

submitted 75 days ago • 1 comment

A little fun with numbers on this Sunday, showing just how successful DNA really is. First, here's what DNA looks like. I'll draw your attention to the "rise" in DNA, that is, the distance between two basepairs, which is 3.4 Angstroms, also known as 3.4x10^-10 meters...

submitted 80 days ago • 4 comments

Mix two motors of opposite polarity with microtubules and they will partition space ! Microtubules will get organized in polar and active barriers, sorting the two motors in separated domains, leading to the emergence of a new type of patterns. #morphogenesis doi.org/10.1073/pnas... (1/n)

submitted 91 days ago • 8 comments

Does anyone know the best and original references for absolute quantification of ChIP-Seq and RNA-Seq, using spike-in normalization?

submitted 92 days ago • 13 comments

In this review @gracebower.bsky.social & I discuss recent evidence showing that, unlike canonical enhancers, long-range enhancers located hundreds of kb from their targets rely on additional mechanisms to ensure robust gene activation during mammal development. www.sciencedirect.com/science/arti...

submitted 96 days ago • 1 comment

This was a great talk at #EMBLomics by @molinalab.bsky.social

submitted 96 days ago • 1 comment

Research funded by NIH generated $2.46 in economic activity for every $1 of funding in 2023 [a total of $92.9 billion] www.fiercebiotech.com/research/rep...

submitted 100 days ago • 2 comments

Epigenetics and chromatin crowd: What was a (or the) paper you read early on that made you think "wow, I'm in the right field". Mine is the classic on plant imprinting from Tetsuji Kakutani's group (Kinoshita et al., Science 2004) doi.org/10.1126/scie...

submitted 108 days ago • 19 comments

Fantastic to have our preclinical study led by Richard Voit and colleagues on a universal gene therapy approach for #DiamondBlackfanAnemia by regulated GATA1 expression published earlier this week: www.cell.com/cell-stem-ce...

submitted 102 days ago • 0 comments

In September the world lost one of the great biologists of our time: Joe Gall. He bridged the transition from the histology era of cell biology to our molecular present, contributing a remarkable set of insights in his 9 decades 1/n 🧪 rupress.org/jcb/article-...

submitted 102 days ago • 7 comments

Hi Bluesky! I made a 3D chromatin starter pack. Let me know if you would like to be added. go.bsky.app/6tTQdqQ

submitted 105 days ago • 40 comments

Made a new starter pack for labs developing and applying advanced microscopy for biological discovery. Definitely still missing loads of labs, write me to be added. go.bsky.app/SHQCnEe

submitted 105 days ago • 12 comments