auclairdan.bsky.social - Profile | ThreadSky | a Reddit-style client for Bluesky

Lung-MAP 3.0. Adding NGS screening options for patient recruitment ascopost.com/issues/febru...

submitted 2 days ago • 0 comments

The time relegated to being data clerks among US physicians is increasing jamanetwork.com/journals/jam...

submitted 2 days ago • 10 comments

Pitt to pause PhD admissions, following Vanderbilt and USC, because of uncertainty of NIH funding to academic universities. Who will teach and train US scientists for pharma and biotech? Should we import them from countries that do? www.wesa.fm/health-scien...

submitted 4 days ago • 8 comments

One of many similar stories to come out in the last week. A sad state of affairs.

submitted 4 days ago • 0 comments

Turmoil at FDA and fears it might impact new drug approvals www.biospace.com/fda/fda-reel...

submitted 6 days ago • 0 comments

Illumina unveils its novel spatial transcriptomics platform www.illumina.com/company/news...

submitted 6 days ago • 0 comments

US researchers are in shock. What to expect next. www.nature.com/articles/d41...

submitted 6 days ago • 1 comment

Genetic disruption of Blimp-1 drastically augments the antitumor efficacy of BCMA-targeting CAR T cells #MyelomaSky ashpublications.org/bloodadvance...

submitted 8 days ago • 0 comments

NIH reportedly loses two top leaders in two days www.qcnews.com/nexstar-medi...

submitted 13 days ago • 0 comments

Congrats, and happy to see your labor of love coming to fruitions Jonathan @pedalheadphx.bsky.social #MyelomaSky

submitted 13 days ago • 0 comments

go.bsky.app/BtBs6xj Still slowly building a myeloma research oriented starter pack, let me know if you are missing.

submitted 17 days ago • 2 comments

Characterization of plasma cell-free DNA variants as of tumor- or clonal hematopoiesis-origin in 16,812 advanced cancer patients aacrjournals.org/clincancerre...

submitted 15 days ago • 0 comments

Mass General Brigham announces largest layoff in its history amid ongoing restructuring - via @bostonglobe.com www.statnews.com/2025/02/10/m...

submitted 16 days ago • 4 comments

A federal judge issued a nationwide temporary pause on plans by the NIH to substantially slash research overhead payments www.statnews.com/2025/02/11/j...

submitted 15 days ago • 0 comments

Bold editorial by the Lancet today American chaos: standing up for health and medicine

submitted 18 days ago • 0 comments

This STAT article hits the nail on the head www.statnews.com/2025/02/08/n...

submitted 18 days ago • 0 comments

#MyelomaSky #HemeSky

submitted 18 days ago • 0 comments

Congrats for this important work. CEPHEUS study of Dara+VRd vs. VRd: MRD-negativity 60.9% for quad vs. 39.4% w/ VRd; ≥CR rates 81.2% vs. 61.6%; sustained MRD negativity (≥12 mos) 48.7% vs. 26.3%, 43% lower progression or death risk #MyelomaSky @szusmani.bsky.social pubmed.ncbi.nlm.nih.gov/39910273/

submitted 18 days ago • 1 comment

#BREAKING - NIH plans to slash support for indirect research costs, sending shockwaves through science

submitted 19 days ago • 4 comments

This is big, and not a good way, for academic research and labs.

submitted 19 days ago • 0 comments

IL-27 elicits a cytotoxic CD8+ T cell program to enforce tumor control @nature.com nature.com/articles/s41...

submitted 21 days ago • 0 comments

The promise of a personalized (neoantigen) vaccine for treating cancer, as seen by immune response bolstering against renal cell carcinoma in a Phase 1 trial nature.com/articles/d41... nature.com/articles/s41...

submitted 21 days ago • 7 comments

There's widespread confusion and fear among scientists and doctors on the sprawling National Institutes of Health campus and at institutions dependent on the agency's funding.

submitted 22 days ago • 50 comments

NIH resumes grant reviews after 2 weeks pause www.statnews.com/2025/02/04/t...

submitted 22 days ago • 0 comments

T-cell immune cluster analysis using CyTOF identifies unique subgroups of patients with acute myeloid leukemia #HemeSky ashpublications.org/bloodadvance...

submitted 22 days ago • 0 comments

#WorldCancerDay coincides with my dad’s birthday whom I lost to DLBCL. Great hope with new tools (immune & cell therapies, degraders, molecular glues, etc.). Cancer cells are smart, we still have lot to learn about biology & get better at early #detection #interception Keep fighting and innovating!

submitted 22 days ago • 0 comments

Agree with @scaltritilab.bsky.social on the importance of reverse translation medicine. We need to learn from what is happening in patients in order to better accelerate new cancer discoveries and therapies #HemeSky #MedSky www.nature.com/articles/s43...

submitted 22 days ago • 1 comment

A long-awaited nonopioid pain drug has won approval from the U.S. Food and Drug Administration (FDA) to treat moderate to severe short-term pain.

submitted 26 days ago • 1 comment

On #NationalWomenPhysiciansDay remembering Dr. Elizabeth Blackwell, US first female doctor. After dozens of rejections, she finally got into GMCNY in 1847, her acceptance having been put to vote before the medical class. Legend has it they thought it was a joke healthmatters.nyp.org/happened-dr-...

submitted 23 days ago • 0 comments

CAR trogocytosis transfers antitumor immunity between T cells and is dictated by their transmembrane domain @sciimmunology.bsky.social www.science.org/doi/10.1126/...

submitted 26 days ago • 0 comments

The current landscape and emerging challenges of benchmarking single-cell methods www.biorxiv.org/content/10.1...

submitted 26 days ago • 0 comments

National Science Foundation suspends salary payments, leaving researchers unable to pay their bills www.statnews.com/2025/01/30/t... Story by @ericboodman.bsky.social

submitted 27 days ago • 62 comments

In HCC patients treated with anti-PD-1 and lenvatinib, a circulating effector memory CD8+ T cell population is critical for treatment efficacy www.cell.com/cancer-cell/... www.cell.com/cancer-cell/... preview by @meganburgerphd.bsky.social @cp-cancercell.bsky.social

submitted 27 days ago • 0 comments

The T cell receptor sequence influences the likelihood of T cell memory formation www.cell.com/cell-reports...

submitted 27 days ago • 0 comments

Single-cell multiomics reveal divergent effects of DNMT3A- and TET2-mutant clonal hematopoiesis in inflammatory response #HemeSky ashpublications.org/bloodadvance...

submitted 29 days ago • 0 comments

From the UChicago Kline Lab in @bloodjournal.bsky.social: multi-omic characterization of 4 'immune quadrants' in DLBCL, with better response to bispecifics (but not CAR-T) in "GCB Hot" versus "GCB Cold." #lymsm #tcellrx https://ashpublications.org/blood/article/doi/10.1182/blood.2024025355/535294/I…

submitted 30 days ago • 0 comments

International myeloma working group immunotherapy committee recommendation on sequencing immunotherapy for treatment of multiple myeloma #MyelomaSky www.nature.com/articles/s41...

submitted 30 days ago • 0 comments

Perspective from @ireneghobrial.bsky.social and Omar Nadeem on early intervention with daratumumab for HR-SMM #MyelomaSky #HemeSky www.nature.com/articles/s41...

submitted 31 days ago • 0 comments

Boosting B cells in blood-derived organoids www.nature.com/articles/s41... #HemeSky #MedSky

submitted 32 days ago • 0 comments

Architects of immunity: How dendritic cells shape CD8+ T cell fate in cancer www.science.org/doi/10.1126/...

submitted 32 days ago • 0 comments

ashpublications.org/blood/articl... Props to the Finnish team for the amazing idea to assess the ex vivo sensitivity of Ven in AML patients, both de novo and relapsed. This approach can be quickly integrated to all large hospitals' labs and inform the best tx approach for elderly AML patients!

submitted 34 days ago • 0 comments

Life expectancy in the US —by educational attainment, by county www.thelancet.com/journals/lan... @ihmeuw.bsky.social —the growing inequalities abcnews.go.com/Health/growi... @amymaxmen.bsky.social @kffhealthnews.bsky.social

submitted 34 days ago • 12 comments

A new mechanism for cancer-induced immune evasion. We knew about cancer cells hijacking mitochondria. Now we learn about how their mitochondrial transfer to T cells impairs the tumor immune response. www.nature.com/articles/s41... www.nature.com/articles/d41...

submitted 35 days ago • 8 comments

AURIGA study results: - D-R maintenance improved MRD-conversion rate in NDMM patients who were MRD+ after transplant vs R maintenance. - PFS favored D-R maintenance, with an improved 30-month PFS rate vs R alone; D-R was well tolerated #MyelomaSky #HemeSky ashpublications.org/blood/articl...

submitted 35 days ago • 0 comments

More than 40% of postdoctoral researchers leave academia, according to a study of some 45,500 researchers’ careers https://go.nature.com/3EdzX56

submitted 36 days ago • 5 comments

Congrats to all 2025 @ash.hematology.org ASH Scholar Award recipients!

submitted 36 days ago • 0 comments

#REVIEW 🚨 @christian-kratz.bsky.social highlights the genetics of cancer in children, examining cancer predisposition syndromes + genes, embryonic mosaicisms & polygenic risk scores, focusing on their role in cancer prediction, prevention, surveillance & therapy response. 📖👇 bit.ly/3ZHhZAA

submitted 36 days ago • 0 comments

Depth of response is important in predicting better outcome not only in myeloma active disease (which led to MRD as an IE in ‘24) but also in precursor high-risk smoldering. Results of the I-PRISM phase II trial @ireneghobrial.bsky.social #MyelomaSky #HemeSky www.nature.com/articles/s41...

submitted 36 days ago • 0 comments

An epigenetic pathway regulates MHC-II expression and function in B cell lymphoma models #HemeSky www.jci.org/articles/vie...

submitted 36 days ago • 0 comments