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azbiomarkers.bsky.social
Precision medicine translational pharmacologist and cancer biologist, utilizing evidence based medicine to move biomarkers into the clinic. Views are my own.
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A very cool thing about getting older in medicine: eventually you see a dreaded disease of your early career succumb to science. Once you witness it a few times, nothing will seem impossible to you in the same way ever again. #MedSky #DrugDevelopment

🚨 The #AVITI24 Global Grant Program is here! Apply today for your chance to win Teton™ CytoProfiling services from Element Biosciences. 🧬 Simply tell us how you'd use high dimensional multiomics in your research. Apply today: bit.ly/3F64bYc

🧪 New #sourcerequest: I'm looking to speak with students or early career academics who use AI for data collation, experimental planning, literature review, writing, referencing and statistical analysis. I'd love to hear about the specific tools you use and how you use them.

The time relegated to being data clerks among US physicians is increasing jamanetwork.com/journals/jam...

Important implications in the best approach to molecular/minimal residual disease testing in solid tumors: Clonal driver neoantigen loss under EGFR TKI and immune selection pressures www.nature.com/articles/s41...

Even low levels of ctDNA may signal higher recurrence risk in early-stage lung adenocarcinoma. A new study shows that sensitive tests like NeXT Personal can help personalize treatment & improve outcomes. Early detection is crucial. #LungCancer #ctDNA ascopost.com/news/january...

New @biorxivpreprint.bsky.social preprint from Amgen induced proximity group and @dannomura.bsky.social lab just posted that describes Covalent Destabilizing Degrader of AR and AR-V7 in Androgen-Independent Prostate Cancer Cells. Read on for an overview 1/7 www.biorxiv.org/content/10.1...

Functional analysis of cancer-associated germline risk variants www.nature.com/articles/s41...

Encouraging data in treatment of NRG1 fusion + cancers: Efficacy of Zenocutuzumab in NRG1 Fusion–Positive Cancer www.nejm.org/doi/full/10....

Gene editing technology began by people studying salt marshes. Ozempic began by folks studying the venom of Gila Monsters. Support for basic science has empowered us to understand our world. Tethering it to applications health has transformed and saved countless lives.

New from #JCOOA: "Oncologists ... are experiencing higher rates of burnout compared with a decade ago. System-based interventions ... are necessary to maintaining an adequate workforce to provide care for current and future patients..." ascopubs.org/doi/10.1200/... #JCOOA #JCOJournals #OpenAccess

During WWII the Holocaust killed millions. (Today’s) Poland was most heavily impacted.

Keep button batteries locked up out of sight and out of reach of kids.

Data from #ASCOGI25 (society.asco.org/about-asco/p...) shows a 50% decrease in CRC recurrence in a randomized trial at 3yrs. in PIK3CAmut + cancers with daily 160mg dose. Abstract LBA125

After 80 years, not many Auschwitz survivors are left. One man makes telling the stories his mission.

Supplement your #GI25 experience with #ASCOEdBook review articles: brnw.ch/21wQeaY

Come be my boss! We're looking for a new Program Head for the Molecular Medicine Program at the Hospital for Sick Children. Toronto, Canada (the deadline has been extended from Jan 31) Please Re-post. jobs.sciencecareers.org/job/667223/p...

Article in press in The Journal of Molecular Diagnostics by AMP member Danny Miller and colleagues: Concordance of Whole-Genome Long-Read Sequencing with Standard Clinical Testing for Prader-Willi and Angelman Syndromes Abstract: www.jmdjournal.org/article/S152...

"Most people trust scientists and agree that scientists should engage more in society and policymaking" From a 68-country assessment. Open-access www.nature.com/articles/s41...

Not to be missed: #JCOOP comprehensive special issue on #financialtoxicity in #cancercare guest edited by @fumikochino.bsky.social and @ryannipp.bsky.social ascopubs.org/toc/op/current @ascocancer.bsky.social

Interesting solution to a vexing problem: how do we separate signal from noise in NGS data outputs? removing SNPs w/ VAF less than ~ 0.30 reduces curation T 20% Establishing a Variant Allele Frequency Cutoff for Manual Curation of Medical Exome Sequencing Data www.jmdjournal.org/article/S152...

Are you a graduate/professional student or early career professional who wants to learn about global development/diplomacy? Apply to Duke's Global Policy Program in Geneva! We have 3 tracks: humanitarian action, global health, trade Priority deadline: Jan 10, 2025 sanford.duke.edu/academics/sp...

Does coffee prevent head and neck cancer? "Coffee and tea consumption was linked with lower risks of developing head and neck cancers, including cancers of the mouth and throat." Open Access acsjournals.onlinelibrary.wiley.com/doi/full/10....

Attention Lung Cancer patients! Please participate in this research survey. It only takes about 10 minutes. www.surveymonkey.com/r/37P79WB @devikadasmd.bsky.social @ishwaria.bsky.social #lcsm

#OncSky #MedSky #PharmSky #MedEd This page summarizing basis of each #cancer drug approval in reverse date order is a great resource for fellows, busy clinicians, & anyone prepping for Boards (or LKA quarterly questions ⏳…). Bookmark & share. www.fda.gov/drugs/resour... #DrugDevelopment

One of the forgotten costs of cancer therapy is time spent in the clinic. Report on time toxicity in JCO Oncology Practice on pts with lung cancer showed 22% of days alive had in person visits: 24% with chemotherapy, 21% for immunotherapy, 16% for targeted therapy. #LCSM ascopubs.org/doi/10.1200/...

The BEST part of my day is when I find a NGS report with a targetable mutation! What a time to practice thoracic oncology! #lcsm 🛑 All patients with lung cancer⭐️NEED ⭐️ comprehensive biomarker testing.

Details on uncommon #EGFR mutations @jtoonline.bsky.social. In 5212 #EGFR NSCLC dataset, 8.9% were uncommon mutations: associated with smoking history, higher rates of EGFR amp and TP53 co-mt, shorter time on TKI (4.1m) vs common (10.9m). #LCSM #OncSky www.jto.org/article/S155...

🩸Hematopoietic stem cell differentiation with cytokine regulation #hemesky #hemeonc #medsky #IMsky #internalmedicine #hemepath #pathsky #stemcells

Our "Molecular Medicine for Patients" website has lots of great resources (in English and Spanish) for anyone interested in molecular diagnostics. Give it a look and share it with anyone who'd like to learn what happens in a molecular diagnostic laboratory. outreach.amp.org/

Three must read papers for PhD students. #scisky #PhD #science #research #academicsky 1. The importance of stupidity in scientific research Open Access journals.biologists.com/jcs/article/...

#SABCS24 #bcsm #OncSky #SurgSky #MedSky 📣 INSEMA Trial Omission of sentinel node biopsy (SLNB) in pts w/ clin node-neg early #breastcancer did not result in inferior IDFS (@ 6 yrs: 91.7 vs 91.9%). Suggests no SLNB may be👌 for age 50+ w/ gr 1-2, ER+/HER2- tumors, up to 2 cm @oncoalert.bsky.social