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bengoult.bsky.social
Talin as a memory molecule #MeshCODE. Talin shock absorbing materials #TSAM. Professor of Mechanistic Cell Biology at University of Liverpool Dad, Husband. Hobbies: Mechanobiology, talin, looking at the sky
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Interested in nuclear mechanobiology, and how advanced genomic tools can shed light on how the cell nucleus might sense mechanical forces? Read our latest review by excellent Julien Morival and Anna Hazelwood, now published @jcellsci.bsky.social: journals.biologists.com/jcs/article-...

Was good flowering whilst it lasted.

A great visit to @merln-um.bsky.social in Maastricht, and nice to finally meet Aurélie Carlier in person after collaborating for ages. Very interesting discussion after my talk. Also, thanks for my Mosasaur tooth :)

Big first for our lab on Friday as Wesley became its first PhD graduate. Congrats Wesley and a big thanks to an amazing committee including @bengoult.bsky.social (opponent), @sciezgin.bsky.social , Gunilla Westergren-Thorsson, Catharina Hagerling and Daniel Engelbertsen.

Sparse.

Train from Denmark to Sweden. (I’ve always wanted to cross this bridge since watching The Bridge 😀)

🎙️MERLN Speaker Series will feature Prof. Dr. Ben Goult on Feb 11, presenting ‘TALIN in MECHANOmemory – spatial organisation by binary mechanochemical switches.’ 🌟Join us and discover how TALIN switches interact with enzymes 👀 and their roles in disease with @bengoult.bsky.social

Looking forward to visiting @merln-um.bsky.social in Maastricht next week.

Interesting article about our recent paper on talin and Amyloid Precursor Protein. royalsocietypublishing.org/doi/10.1098/...

Tallinn

Every person who placed their recycling bins in the middle of the path during a gale, should have to do litter picking today.

We had the privilege of hosting Ben Goult @bengoult.bsky.social in Strathclyde/Glasgow, invited by Carsten @carstenschulte4.bsky.social, to discuss his beautiful MeshCODE theory.

A reminder to colleagues interested in Cell-Matrix adhesion & anything ECM related that registration is now open for the Fibronectin, Integrins & related molecules Gordon Research Conference. Incredible list speakers! incredible location! it will 🔥 🔥 🔥 Please join us! www.grc.org/fibronectin-...

Trying something new: For our recent preprint: Fast label-free live imaging reveals key roles of flow dynamics and CD44-HA interaction in cancer cell arrest on endothelial monolayers www.biorxiv.org/content/10.1... I made an online presentation: www.beautiful.ai/player/-ODGe...

For early career researchers interested in the Fibronectin, Integrins and Related Molecules GRS/GRC this May, don’t forget to sign up! The deadline for submitting an abstract to be considered for an oral presentation for the GRS is less than a week away! Register here: www.grc.org/fibronectin-...

Moon

This photo of view from office is a strange image.

Lab Christmas Dinner 2024 (slightly belated).

My Nespresso Wrapped is very boring, showing I i) drink far too much mid-tier coffee and ii) I do not mix it up (they even call it "1 varieties")

We are delighted to announce that we have been awarded a Gold #AthenaSwan Award from @advancehe.bsky.social! Thank you to the ISMIB Athena Swan Team who made this all possible! #GenderEquality | #TeamLivUni bit.ly/4jcgcew

Commissioned rug as a Xmas present, really enjoyed making this one! #tufting #art #TalinMerch

Our friend makes custom rugs, and so my wife sent her one of our structure images and she made it from that. This was the original (it was quite lucky as PyMOL crashed rendering it so the colours are really distinct).

Anti-lock braking systems (ABS) are amazing, look at this doofus in the snow last night.

New rug for my office! 😃 Amazing Christmas gift, a beautiful hand-crafted Talin rug. #TalinMerch

I have a funded PhD studentship available to start in my new lab in 2025! If you are interested in Endosomal Biology, Astrocytes and Alzheimer’s Disease have a look: www.findaphd.com/phds/project... Please feel free to share.

A long read from 2017 but well worth the time for any scientist who both loves their job and and often finds themselves questioning their life decisions. www.danielnettle.org.uk/wp-content/u...

New paper out today in @jci-insight.bsky.social We show that "Talin1 dysfunction is genetically linked to systemic capillary leak syndrome (SCLS)." insight.jci.org/articles/vie... with Vasso Kostorou, Tamar Harel, Naama Elefant, Doron Lancet and their teams.

Two were while I was presenting data!

Not nearly enough 💤

*Fully funded PhD position available in the lab* We will use structural proteomics to map the mechanosensitive interactions of talin in dendritic spines and how they change during long term potentiation. Please share, and email for details :) www.findaphd.com/phds/project...

"SoCoBio Collaborative Student Publication: Charles Ellis, Natasha Ward and Matthew Rice" - Write up on the SoCoBio DTP website on our talin-APP paperp @socobiodtp.bsky.social southcoastbiosciencesdtp.ac.uk/news/socobio...

Celebrating 3rd year SoCoBio student's first 'first' authorship publication! www.linkedin.com/posts/charli...

Press release on the nice paper from @mark-morgan.bsky.social lab on the integrin αVβ6-HER2 cross-talk. www.science.org/doi/10.1126/...

There are only ~20000 proteins in the human proteome but it is remarkable how often you learn about totally new ones that do really amazing things. I wonder what %age of them I actually know?

Look at the amazing speaker list for Adhere2 next September! This is going to be an excellent meeting, in beautiful Zadar, Croatia. event.fourwaves.com/adhere2/page...

Not sure how that’s happened but our son turned 21 today! 😱🎉

"Mechanical switches and protein meshes – this is a new way of looking at one of our most feared diseases." Excellent article on our work from @iflscience.com www.iflscience.com/a-shapeshift...

Only 3 days left to apply! Postdoc positions available in the Röper lab at the University of Cambridge! @PDN_Cambridge Discover the role that supracellular cytoskeletal assemblies and crosstalk play in sculpting organs in Drosophila or human organoids in culture! Links below!

I really want to highlight this paper and 🧵by @bengoult.bsky.social for the #Mechanotransduction community, linking the #MeshCODE theory to pathophysiological implications in Alzheimer's disease. Congratulations Ben, fantastic paper and discussion section🤯: