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bernhardbein.bsky.social
PhD student in comparative genomics @ Senckenberg and Goethe University Frankfurt
9 posts 12 followers 30 following
Getting Started
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This looks extremely promising and it works with smallish amounts of input DNA. Why? Because it applies long range PCR amplification with 'polC' (KOD Xtreme™ Hot Start DNA polymerase) that we investigated in depth here: genomebiology.biomedcentral.com/articles/10.... #PacBio #HiFiSequencing #PCR

submitted 4 days ago • 0 comments

With @katiejenike.bsky.social and a bunch more of our fellow k-mer enthusiasts, we put together a manuscript on k-mers in biodiversity genomics. A guide if you will, that covers k-mers from basics to some really funky stuff... genome.cshlp.org/content/35/2...

submitted 13 days ago • 1 comment

Thrilled to share our work on unlocking challenging specimens for @pacbio.bsky.social #HiFi sequencing, now out in Genome Biology! genomebiology.biomedcentral.com/articles/10.... We show that specimens that have been stored in ethanol for decades can still be amenable for long-read sequencing:🧵

submitted 18 days ago • 2 comments

Glad to see our preprint out! We reconstructed diet evolution in bats and support ancestral omnivory of the ecologically diverse bat family Phyllostomidae.

submitted 20 days ago • 0 comments

‼️These #PSMC #peaks are #artifacts‼️ Seen #PSMC results like this🤔? They are caused by ill-set parameters, #very #common, and #easy #to #solve! For details see 🧵& OA paper @currentbiology.bsky.social 🙂🐢🧬🎉! cell.com/current-biol...

submitted 21 days ago • 1 comment

With the new #PacBio Ampli-Fi protocol, you can now sequence genomes with as little as 1 ng of DNA! Paired with our #HiFisequencing technology, it provides a powerful solution for assembling high-quality genomes with exceptional accuracy. #PAG32

submitted 45 days ago • 0 comments

Happy to report that our work on immune system adaptations in bats is now out in @nature.com 🦇🧬 www.nature.com/articles/s41... @ariadnamorales.bsky.social @batresearch.bsky.social @virology.bsky.social @DGKontopoulos.ecoevo.social.ap.brid.gy @sgn.one @bat1kgenomes.bsky.social Read more ...

submitted 30 days ago • 4 comments