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Biology OA is open to all angles of life science and biotech 🦠🍄🧫🧪🔬🧬 #BioSky #MicroSky
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This research investigates how a nascent bacterial community adapts over time, focusing on two E. coli ecotypes. It analyzes gene knockouts in different conditions, revealing fitness patterns and correlations with evolution, highlighting environmental and epistatic factors in adaptation.

submitted 6 days ago • 0 comments

Introducing geNomad, a framework to identify and characterize plasmids and viruses in sequencing data. With a dataset of 200k+ protein profiles and a conditional random field model, geNomad has processed 2.7T base pairs, discovering millions of new viruses and plasmids.

submitted 10 days ago • 0 comments

Created using single-cell RNA sequencing and spatial transcriptomics, this high-res atlas of the adult mouse brain reveals cell-type differences between dorsal and ventral regions. This study is a key resource for future brain research.

submitted 16 days ago • 0 comments

DNA extraction methods affect perceived composition of eukaryotic and prokaryotic microbes. The bias is greater for eukaryotes, especially soft-bodied and hard-shelled species. These methods are crucial for accurate study of eukaryotic communities in biofilms.

submitted 85 days ago • 0 comments

Research targets DNA break repair to combat E. coli #AntibioticResistance. Defects in this pathway can resensitize bacteria to antibiotics, increasing their kill rate. Break-repair inhibitors could suppress antibiotic resistance mutations.

submitted 87 days ago • 0 comments

This study used MALDI-TOF mass spectrometry and machine learning to differentiate between closely related bacteria species #Escherichia coli and #Shigella. Lipid profiling was found to be a potential method for accurate discrimination.

submitted 89 days ago • 0 comments

This study explored alkaliphilic #biofilm evolution in extreme pH. Biofilms manipulated their environment for pH buffering, aiding survival at high pH. At pH 13, #Dietzia sp. and #Anaerobranca sp. dominated the biofilm community.

submitted 90 days ago • 0 comments

This paper presents advanced fluorescent biosensors for #Listeria spp., suitable for high-throughput #antimicrobial screenings via flow cytometry. The biosensors exhibit enhanced fluorescence and pH sensitivity, ideal for #singlecell analysis.

submitted 91 days ago • 0 comments

Sporulation in #Schizosaccharomyces pombe is a survival response to nutrient starvation. It involves sexual differentiation and lifespan extension, producing resistant spores. Research continues to understand its molecular mechanisms and benefits.

submitted 93 days ago • 0 comments

This study examined #biofilm formation in a #microfluidic flow cell. It found that higher wall shear stress led to thinner biofilms, and biofilm development varied on different surfaces. Biofilm streamers were also observed under laminar flow.

submitted 94 days ago • 1 comment

Mutant #Escherichia coli strain produced high amounts of vesicles with a specific protein. Non-uniform sampling yielded high-resolution #NMR spectra of the protein in its native lipid environment, showing potential for future vesicle-based solution NMR research.

submitted 96 days ago • 0 comments

This study identified acetylated diether lipids in halophilic #Archaea, specifically in #Haloferax volcanii and #Halobacterium salinarum. The enzyme YvoF was found to be responsible for acetylating these lipids, potentially modifying their polarity.

submitted 97 days ago • 1 comment

#Metagenomics is a powerful tool for understanding microorganisms in complex environments. This paper provides a review of the principles and methods used in metagenomics, with a focus on reconstructing individual genomes.

submitted 101 days ago • 0 comments

Research on #Saccharomyces cerevisiae #biofilms shows pH and FLO11 expression vary among strains. pH is not linked to mat complexity, while increased FLO11 is associated with morphological complexity. Traits exist independently of mat complexity.

submitted 126 days ago • 0 comments