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Ontogeny Dictates Oncogenic Potential, Lineage Hierarchy, and Therapy Response in Pediatric Leukemia https://www.biorxiv.org/content/10.1101/2025.03.19.643917v1

submitted 5 hours ago • 0 comments

Metabolic reinvigoration of NK cells by IL-21 enhances immunotherapy against MHC-I deficient solid tumors https://www.biorxiv.org/content/10.1101/2025.03.19.643961v1

submitted 14 hours ago • 0 comments

Measuring Longitudinal Genome-wide Clonal Evolution of Pediatric Acute Lymphoblastic Leukemia at Single-Cell Resolution https://www.biorxiv.org/content/10.1101/2025.03.19.644196v1

submitted 14 hours ago • 0 comments

Resilience and vulnerabilities of tumor cells under purine shortage stress https://www.biorxiv.org/content/10.1101/2025.03.19.644180v1

submitted 15 hours ago • 0 comments

Mast cells interact directly with colorectal cancer cells to promote epithelial-to-mesenchymal transition https://www.biorxiv.org/content/10.1101/2025.03.19.644113v1

submitted 19 hours ago • 0 comments

Increased mRNA translation delays lung adenocarcinoma initiation and exposes a therapeutic vulnerability to MEK inhibitors https://www.biorxiv.org/content/10.1101/2025.03.19.644135v1

submitted 21 hours ago • 0 comments

Opposite patterns of association of TWIST1 expression with patient survival in SHH and Group 4 medulloblastoma https://www.biorxiv.org/content/10.1101/2025.03.19.644169v1

submitted 21 hours ago • 0 comments

Single-cell spatial analysis of pediatric high-grade glioma reveals a novel population of SPP1+/GPNMB+ myeloid cells with immunosuppressive and tumor-promoting capabilities https://www.biorxiv.org/content/10.1101/2025.03.18.643953v1

submitted 1 day ago • 0 comments

Human TIMELESS, a potential circadian clock regulator, plays an essential role in survival and reawakening of metastasis-initiating cells in bone https://www.biorxiv.org/content/10.1101/2025.03.18.643632v1

submitted 1 day ago • 0 comments

RNA polymerase II O-GlcNAcylation promotes nuclear entry to drive transcription https://www.biorxiv.org/content/10.1101/2025.03.18.643968v1

submitted 1 day ago • 0 comments

Spatial analysis of IPMNs defines a paradoxical KRT17-positive, low-grade epithelial population harboring malignant features https://www.biorxiv.org/content/10.1101/2025.03.18.643943v1

submitted 1 day ago • 0 comments

Lineage Tracing Reveals Clone-Specific Responses to Doxorubicin in Triple-Negative Breast Cancer https://www.biorxiv.org/content/10.1101/2025.03.18.643980v1

submitted 1 day ago • 0 comments

Multidimensional characterization of cellular ecosystems in Hodgkin lymphoma https://www.biorxiv.org/content/10.1101/2025.03.18.643177v1

submitted 1 day ago • 0 comments

Epithelial Ikkβ deletion modulates immune responses and the IFNγ/CXCL9 axis during early esophageal carcinogenesis https://www.biorxiv.org/content/10.1101/2025.03.18.643566v1

submitted 1 day ago • 0 comments

IL-1β/IRAK4 Axis Promotes Ovarian Tumor Development at the Mesothelium Injury Sites https://www.biorxiv.org/content/10.1101/2025.03.18.643950v1

submitted 1 day ago • 0 comments

The carnosinase dipeptidase CNDP1 is a novel metabolic vulnerability in brain metastasis https://www.biorxiv.org/content/10.1101/2025.03.18.644053v1

submitted 1 day ago • 0 comments

Acquired resistance to sotorasib in <KRASG12C> mutant NSCLC is vulnerable to PI3K-mTOR pathway inhibition mediated by 4E-BP1 regulator of cap-dependent translation https://www.biorxiv.org/content/10.1101/2025.03.18.643954v1

submitted 1 day ago • 0 comments

A tumor-suppressive role of the PRC1 Polycomb epigenetic complex in the maintenance of adult Drosophila intestinal stem cell identity https://www.biorxiv.org/content/10.1101/2025.03.18.643963v1

submitted 1 day ago • 0 comments

Inferring Phylogenetic Trees of Cancer Evolution from Longitudinal Single-Cell Copy Number Profiles https://www.biorxiv.org/content/10.1101/2025.03.17.643834v1

submitted 1 day ago • 0 comments

Identification of a shared persistence program in triple-negative breast cancer across treatments and patients https://www.biorxiv.org/content/10.1101/2025.03.17.643634v1

submitted 1 day ago • 0 comments

Stochastically Emergent Tumors offer in vivo whole genome interrogation of cancer evolution from non-malignant precursors https://www.biorxiv.org/content/10.1101/2025.03.17.643814v1

submitted 1 day ago • 0 comments

Individualized pseudogenes networks for survival prognosis in B-cell acute lymphoblastic leukemia https://www.biorxiv.org/content/10.1101/2025.03.14.643224v1

submitted 2 days ago • 0 comments

Podoplanin-Linked Mesenchymal Shift Synergizes with CCR7 driving Lymphatic Metastasis and Tumor Progression in Breast Cancer https://www.biorxiv.org/content/10.1101/2025.03.17.643704v1

submitted 2 days ago • 0 comments

Total body irradiation primes CD19-directed CAR T cells against large B-cell lymphoma https://www.biorxiv.org/content/10.1101/2025.03.17.643462v1

submitted 2 days ago • 0 comments

Effects of alcohol on gut microbiome in adolescent and adult MMTV-Wnt1 mice https://www.biorxiv.org/content/10.1101/2025.03.17.643801v1

submitted 2 days ago • 0 comments

KSHV Reprograms Host RNA Splicing via FAM50A to Activate STAT3 and Drive Oncogenic Cellular Transformation https://www.biorxiv.org/content/10.1101/2025.03.17.643747v1

submitted 2 days ago • 0 comments

Manganese suppresses tumor growth through hyper-activating IRE1α https://www.biorxiv.org/content/10.1101/2025.03.16.643497v1

submitted 2 days ago • 0 comments

Bayesian inference of cell-to-cell interactions in low-nutrient neuroblastoma cell cultures https://www.biorxiv.org/content/10.1101/2025.03.17.643601v1

submitted 2 days ago • 0 comments

Comparative multi-omics analysis uncovers contrasting molecular profiles of canine and human thyroid carcinomas https://www.biorxiv.org/content/10.1101/2025.03.14.643300v1

submitted 2 days ago • 0 comments

LSD1 inhibition corrects dysregulated MHC-I and dendritic cells activation through IFNγ-CXCL9-CXCR3 axis to promote antitumor immunity in HNSCC https://www.biorxiv.org/content/10.1101/2025.03.17.643710v1

submitted 2 days ago • 0 comments

Runx1 and Runx2 act in concert to suppress Wnt/β-catenin-driven mammary tumourigenesis https://www.biorxiv.org/content/10.1101/2025.03.16.643517v1

submitted 2 days ago • 0 comments

Thioredoxin reductase 3 inhibition sensitizes triple-negative breast cancer cells to EGFR inhibitors https://www.biorxiv.org/content/10.1101/2025.03.16.642742v1

submitted 2 days ago • 0 comments

Exploring the relationship between vascular remodelling and tumour growth using agent-based modelling https://www.biorxiv.org/content/10.1101/2025.03.17.643670v1

submitted 2 days ago • 0 comments

Synthetic derivatives of vinpocetine as antiproliferative agents https://www.biorxiv.org/content/10.1101/2025.03.15.643482v1

submitted 2 days ago • 0 comments

A Bivalent Molecular Glue Linking Lysine Acetyltransferases to Oncogene-induced Cell Death https://www.biorxiv.org/content/10.1101/2025.03.14.643404v1

submitted 2 days ago • 0 comments

Differential Phagocytosis induces Diverse Macrophage Activation States in Malignant Gliomas https://www.biorxiv.org/content/10.1101/2025.03.15.642920v1

submitted 2 days ago • 0 comments

In Vivo Multiplexed Modeling Reveals Diverse Roles of the TBX2 Subfamily and Egr1 in Ras-Driven Lung Adenocarcinoma https://www.biorxiv.org/content/10.1101/2025.03.15.642187v1

submitted 2 days ago • 0 comments

SRSF3 is oncogenic in breast but tumor-suppressive in liver by differential regulation of gene expression https://www.biorxiv.org/content/10.1101/2025.03.14.643315v1

submitted 2 days ago • 0 comments

Biobank of genetically defined murine prostate cancer tumoroids uncovers oncogenic pathways and drug vulnerabilities driven by PTEN-loss https://www.biorxiv.org/content/10.1101/2025.03.14.643296v1

submitted 2 days ago • 0 comments

Irinotecan induces intestinal atrophy and compromises duodenal motility and mucosal permeability: in vivo and in vitro evaluations https://www.biorxiv.org/content/10.1101/2025.03.14.643345v1

submitted 2 days ago • 0 comments

ZEB1, a novel regulator of Junctional Adhesion Molecule A, impacts sensitivity of pancreatic cancer-associated fibroblasts to oncolytic reovirus https://www.biorxiv.org/content/10.1101/2025.03.14.643289v1

submitted 2 days ago • 0 comments

Rewiring the fusion oncoprotein EWS/FLI1 in Ewing sarcoma with bivalent small molecules https://www.biorxiv.org/content/10.1101/2025.03.14.643353v1

submitted 2 days ago • 0 comments

Sex Differences in the Cancer Proteome https://www.biorxiv.org/content/10.1101/2025.03.14.643396v1

submitted 2 days ago • 0 comments

A comparative study of the chemotoxic effects of idarubicin and doxorubicin in a chemically-induced in vivo mouse model and in vitro models for hepatocellular carcinoma. https://www.biorxiv.org/content/10.1101/2025.03.14.643356v1

submitted 2 days ago • 0 comments

Stromal cells modulate innate immune cell phenotype and function in colorectal cancer via the Sialic acid/Siglec axis https://www.biorxiv.org/content/10.1101/2025.03.14.642985v1

submitted 2 days ago • 0 comments

Homoharringtonine Promotes FTO Degradation to Suppress LILRB4-Mediated Immune Evasion in Acute Monocytic Leukemia https://www.biorxiv.org/content/10.1101/2025.03.15.643466v1

submitted 2 days ago • 0 comments

Antigenic cancer persister cells survive direct T cell attack https://www.biorxiv.org/content/10.1101/2025.03.14.643359v1

submitted 2 days ago • 0 comments

Targeting processive transcription for Myc-driven circuitry in medulloblastoma https://www.biorxiv.org/content/10.1101/2025.03.14.643337v1

submitted 2 days ago • 0 comments

A bibliometric analysis of research on the mitochondrial roles in prostate cancer and the virtual design of LONP1 - specific antibodies using the GeoBiologics platform https://www.biorxiv.org/content/10.1101/2025.03.14.643215v1

submitted 3 days ago • 0 comments

Targeting Monoallelic CREBBP/EP300 Mutations in Germinal Center-Derived B-Cell Lymphoma with a First-in-Class Histone Acetyltransferase Activator https://www.biorxiv.org/content/10.1101/2025.03.13.642871v1

submitted 3 days ago • 0 comments