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Association of RhoGEF Ect2 with Desmoplakin Supports RhoA Activity at Intercellular Junctions: Implications for Carvajal Disease https://www.biorxiv.org/content/10.1101/2025.05.21.655405v1

submitted 4 hours ago • 0 comments

PIKI-1, a class II phosphatidylinositol 3-kinase, functions in endocytic trafficking https://www.biorxiv.org/content/10.1101/2025.05.22.655458v1

submitted 5 hours ago • 0 comments

Single kinetochores execute an ordered series of molecular events as the Spindle Assembly Checkpoint is silenced https://www.biorxiv.org/content/10.1101/2025.05.23.655733v1

submitted 5 hours ago • 0 comments

Age-associated Tissue Organisation Shifts Retinal Pigment Epithelium Actomyosin Plasticity in Phagocytosis https://www.biorxiv.org/content/10.1101/2025.05.22.655517v1

submitted 5 hours ago • 0 comments

New glucose-abstaining Chlorella algae doubles mammalian cell culture longevity, boosts performance and drops serum needs enabling scaled applications. https://www.biorxiv.org/content/10.1101/2025.05.21.655407v1

submitted 5 hours ago • 0 comments

ALPHA/BETA HYDROLASE DOMAIN CONTAINING 5 SUPPORTS GLUCOSE-STIMULATED-LIPOLYSIS AND INSULIN SECRETION IN PANCREATIC BETA CELLS https://www.biorxiv.org/content/10.1101/2025.05.21.655350v1

submitted 5 hours ago • 0 comments

A Multimodal Spatial and Epigenomic Atlas of Human Adult Lung Topography https://www.biorxiv.org/content/10.1101/2025.05.23.655666v1

submitted 5 hours ago • 0 comments

An innovative in vitro model for studying the biology of cardiac fibroblasts originating from the epicardium https://www.biorxiv.org/content/10.1101/2025.05.23.655755v1

submitted 5 hours ago • 0 comments

Rate Limiting Enzymes in Nucleotide Metabolism Synchronize Nucleotide Biosynthesis and Chromatin Formation https://www.biorxiv.org/content/10.1101/2025.05.21.655426v1

submitted 5 hours ago • 0 comments

Cellular profiling identifies an early profibrotic alveolar type 2 cell signature in lung fibrosis https://www.biorxiv.org/content/10.1101/2025.05.22.655638v1

submitted 6 hours ago • 0 comments

Oculopharyngeal muscular dystrophy (OPMD) associated alanine expansion impairs the function of the nuclear polyadenosine RNA binding protein PABPN1 as revealed by proximity labeling and comparative proteomics https://www.biorxiv.org/content/10.1101/2025.05.23.655706v1

submitted 6 hours ago • 0 comments

Cryo-Correlative Light and X-ray microscopies: Expanding the Intracellular Chemical Map https://www.biorxiv.org/content/10.1101/2025.05.23.655741v1

submitted 6 hours ago • 0 comments

Canonical autophagy remains inactive in induced pluripotent stem cells and neuronal progenitor cells following DNA damage induced by BPDE or etoposide. https://www.biorxiv.org/content/10.1101/2025.05.22.655294v1

submitted 6 hours ago • 0 comments

Mutations in specific MT5-MMP domains prevent the accumulation of toxic APP metabolites and serve as templates for peptide-based therapeutics in cell models of Alzheimer's disease https://www.biorxiv.org/content/10.1101/2025.05.22.655451v1

submitted 6 hours ago • 0 comments

mtTF1: A Novel Factor Involved in Mitochondrial Gene Expression in Trypanosoma brucei https://www.biorxiv.org/content/10.1101/2025.05.22.655275v1

submitted 6 hours ago • 0 comments

A Dual Role for DGAT-mediated Lipid Droplet Biogenesis in Ferroptosis Regulation https://www.biorxiv.org/content/10.1101/2025.05.21.655263v1

submitted 6 hours ago • 0 comments

Senotherapeutic potential against xeroderma pigmentosum https://www.biorxiv.org/content/10.1101/2025.05.22.655641v1

submitted 6 hours ago • 0 comments

RAP1-RHO small GTPase cross-talk mediates integrin-dependent and -independent platelet procoagulant response https://www.biorxiv.org/content/10.1101/2025.05.22.655614v1

submitted 6 hours ago • 0 comments

Nonrandom interchromatin trafficking through dynamic multiphase speckle connections https://www.biorxiv.org/content/10.1101/2025.05.23.655761v1

submitted 6 hours ago • 0 comments

Wasabi leaf extract changes the expression levels of cytokine related genes in dermal papilla cells, which identified by the whole transcriptome https://www.biorxiv.org/content/10.1101/2025.05.20.653605v1

submitted 13 hours ago • 0 comments

A novel role for UPF1 in safeguarding DNA replication in S phase and beyond. https://www.biorxiv.org/content/10.1101/2025.05.22.655556v1

submitted 1 day ago • 0 comments

Polycystin-1 acts as an atypical adhesion GPCR that responds to novel Wnt signaling and mechanical stimuli https://www.biorxiv.org/content/10.1101/2025.05.21.655326v1

submitted 1 day ago • 0 comments

Turbulence orchestrates actin-mitochondria dynamics to preserve GPIbα and support iPSC-derived platelet biogenesis https://www.biorxiv.org/content/10.1101/2025.05.22.655481v1

submitted 1 day ago • 0 comments

A Universal 6iL/E4 Culture System for Deriving and Maintaining Embryonic Stem Cells Across Mammalian Species https://www.biorxiv.org/content/10.1101/2025.05.20.654948v1

submitted 2 days ago • 0 comments

Purification protocol of hypertrophied hepatic stellate cells for their transcriptomic characterization from CDAHFD mice liver https://www.biorxiv.org/content/10.1101/2025.05.19.654829v1

submitted 2 days ago • 0 comments

Acquisition and repeated alteration of (TTGGG)n telomeric repeats in Odonata (dragonflies and damselflies) https://www.biorxiv.org/content/10.1101/2025.05.20.653629v1

submitted 2 days ago • 0 comments

OMA1-mediated cleavage of AIFM1 upon mitochondrial stress and suppression of cell growth through the control of OXPHOS activity https://www.biorxiv.org/content/10.1101/2025.05.19.654756v1

submitted 2 days ago • 0 comments

Dysregulation of alternative splicing patterns in the ovaries of reproductively aged mice https://www.biorxiv.org/content/10.1101/2025.05.19.654918v1

submitted 2 days ago • 0 comments

Podocalyxin and ciliary neurotrophic factor receptor are novel components of the surfaceome of chondrogenic cells https://www.biorxiv.org/content/10.1101/2025.05.19.654853v1

submitted 2 days ago • 0 comments

Molecular Control of Non-Muscle Myosin II-A Aggregation and Intracellular Dynamics by motor- or tail-specific MYH9 Mutations https://www.biorxiv.org/content/10.1101/2025.05.20.654665v1

submitted 2 days ago • 0 comments

JAK/STAT Signaling Governs Airway Epithelial Homeostasis and Stress Resilience in Drosophila https://www.biorxiv.org/content/10.1101/2025.05.20.655050v1

submitted 2 days ago • 0 comments

Cancer-Associated USP28 Missense Mutations Disrupt 53BP1 Interaction and p53 Stabilization https://www.biorxiv.org/content/10.1101/2025.05.20.655034v1

submitted 2 days ago • 0 comments

Inhibition of TBK1/IKKe mediated RIPK1 phosphorylation sensitizes tumors to immune cell killing https://www.biorxiv.org/content/10.1101/2025.05.20.655064v1

submitted 2 days ago • 0 comments

Transcriptional activity generates chromatin motion that drives nuclear blebbing https://www.biorxiv.org/content/10.1101/2025.05.20.655131v1

submitted 2 days ago • 0 comments

Tomosyn-2 Regulates Postnatal β-Cell Expansion and Insulin Secretion to Maintain Glucose Homeostasis. https://www.biorxiv.org/content/10.1101/2025.05.19.654959v1

submitted 2 days ago • 0 comments

SPROUTS_DB: an implemented database of contaminants for extracellular vesicle proteomics studies https://www.biorxiv.org/content/10.1101/2025.05.20.655024v1

submitted 2 days ago • 0 comments

Real-time imaging of transcriptional feedback in nonsense-mediated mRNA decay https://www.biorxiv.org/content/10.1101/2025.05.20.655238v1

submitted 2 days ago • 0 comments

Novel Role of Copper Transporter CTR1 and Therapeutic Potential of Copper Chelators in Retinal Ischemia-Reperfusion Injury https://www.biorxiv.org/content/10.1101/2025.05.17.654687v1

submitted 2 days ago • 0 comments

MINDNet: Proximity interactome of the MICOS complex revealing a multifaceted network orchestrating mitochondrial biogenesis https://www.biorxiv.org/content/10.1101/2025.05.20.655052v1

submitted 2 days ago • 0 comments

Exploring Spike-Dependent and ACE2-Independent Viral Entry into Salivary Epithelial Cells in the Absence of ACE2 https://www.biorxiv.org/content/10.1101/2025.05.19.654917v1

submitted 3 days ago • 0 comments

Matters arising: Forced Symmetry Artifacts in a Prohibitin Complex Structure https://www.biorxiv.org/content/10.1101/2025.05.16.653159v1

submitted 4 days ago • 0 comments

eIF4G2-Mediated Translation Initiation of Histone Modifiers Is Essential for Intestinal Stem Cell Maintenance and Differentiation https://www.biorxiv.org/content/10.1101/2025.05.19.652834v1

submitted 4 days ago • 0 comments

Phosphoribosyl ubiquitination of SNARE proteins regulate autophagy in Legionella infection https://www.biorxiv.org/content/10.1101/2025.05.19.654886v1

submitted 4 days ago • 0 comments

Dynamic hyperplastic cardiac growth in Burmese pythons https://www.biorxiv.org/content/10.1101/2025.05.19.654898v1

submitted 4 days ago • 0 comments

Click Chemistry Enables Rapid Development of Potent sEH PROTACs Using a Direct-to-Biology Approach https://www.biorxiv.org/content/10.1101/2025.05.19.654949v1

submitted 4 days ago • 0 comments

Identification of locally activated spindle-associated proteins in oocytes uncovers a phosphatase-driven mechanism https://www.biorxiv.org/content/10.1101/2025.05.19.654801v1

submitted 4 days ago • 0 comments

SIRT1 limits neuronal fate following DNA damage https://www.biorxiv.org/content/10.1101/2025.05.19.654885v1

submitted 4 days ago • 0 comments

Classification of indeterminate and off-target cell types within human kidney organoid differentiation https://www.biorxiv.org/content/10.1101/2025.05.16.654519v1

submitted 4 days ago • 0 comments

RNAi reveals a unique kinesin mediating chloroplast motility in the giant cytoplasm of Bryopsis, a coenocytic green alga https://www.biorxiv.org/content/10.1101/2025.05.19.654777v1

submitted 5 days ago • 0 comments

ASPPs multimerize protein phosphatase 1 https://www.biorxiv.org/content/10.1101/2025.05.16.654433v1

submitted 5 days ago • 0 comments