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Cellulase secretion by engineered Pseudomonas putida enables growth on cellulose oligomers. https://www.biorxiv.org/content/10.1101/2025.06.19.659671v1

submitted 16 hours ago • 0 comments

Mind the Gap: An Embedding Guide to Safely Travel in Sequence Space https://www.biorxiv.org/content/10.1101/2025.06.19.660524v1

submitted 18 hours ago • 0 comments

Temporal gene regulation enables controlled expression of gas vesicles and preserves bacterial viability https://www.biorxiv.org/content/10.1101/2025.06.20.660610v1

submitted 18 hours ago • 0 comments

Global Assessment of Ligation Reactions in Self-Assembled DNA Nanostructures at the Single-Nick Level https://www.biorxiv.org/content/10.1101/2025.06.18.660358v1

submitted 2 days ago • 0 comments

The Effects of Intraspecies and Interspecies Competition on Genetic Device Construction and Performance https://www.biorxiv.org/content/10.1101/2025.06.17.660092v1

submitted 3 days ago • 0 comments

RNAGym: Large-scale Benchmarks for RNA Fitness and Structure Prediction https://www.biorxiv.org/content/10.1101/2025.06.16.660049v1

submitted 3 days ago • 0 comments

A generalized and efficient approach for complete mRNA design improves translation, stability and specificity https://www.biorxiv.org/content/10.1101/2025.06.17.659751v1

submitted 3 days ago • 0 comments

Establishing betaxanthin pigment biosynthesis in cyanobacteria https://www.biorxiv.org/content/10.1101/2025.06.16.659934v1

submitted 4 days ago • 0 comments

Pathway Sculptor for Compact and Versatile Combinatorial Genetic Perturbation https://www.biorxiv.org/content/10.1101/2025.06.15.659618v1

submitted 4 days ago • 0 comments

A synthetic cell phage cycle https://www.biorxiv.org/content/10.1101/2025.06.14.659709v1

submitted 4 days ago • 0 comments

Synthetic autotrophic yeast enables high itaconic acid production from CO2 via integrated pathway and process design https://www.biorxiv.org/content/10.1101/2025.06.16.659842v1

submitted 4 days ago • 0 comments

NanoBondy reacting through NeissLock anhydride allows covalent immune cell decoration https://www.biorxiv.org/content/10.1101/2025.06.14.659678v1

submitted 6 days ago • 0 comments

Synthetic Rewiring of Virus-Like Particles via Circular Permutation Enables Modular Peptide Display and Protein Encapsulation https://www.biorxiv.org/content/10.1101/2025.06.13.659512v1

submitted 6 days ago • 0 comments

Inducible genome-wide mutagenesis for improvement of pDNA production by E. coli https://www.biorxiv.org/content/10.1101/2025.06.13.659583v1

submitted 6 days ago • 0 comments

Phosphorylation-inducing chimera rewires oncogenic kinase to trigger apoptosis https://www.biorxiv.org/content/10.1101/2025.06.13.659082v1

submitted 7 days ago • 0 comments

Humanized Caffeine-Inducible Systems for Controlling Cellular Functions https://www.biorxiv.org/content/10.1101/2025.06.13.659463v1

submitted 7 days ago • 0 comments

Caffeine-regulated molecular switches for functional control of CAR T cells in vivo https://www.biorxiv.org/content/10.1101/2025.06.13.659487v1

submitted 7 days ago • 0 comments

Treating Myotonic Dystrophy with artificial RNA endonucleases to specifically degrade toxic RNA expansions https://www.biorxiv.org/content/10.1101/2025.06.10.658795v1

submitted 8 days ago • 0 comments

Phage-Assisted Evolution of Allosteric Protein Switches https://www.biorxiv.org/content/10.1101/2025.06.12.659331v1

submitted 8 days ago • 0 comments

Heterologous expression of microbial nitroreductases for TNT degradation in transgenic animals https://www.biorxiv.org/content/10.1101/2025.06.11.659045v1

submitted 9 days ago • 0 comments

OligoSeq: Rapid nanopore-sequencing of single-stranded oligonucleotides https://www.biorxiv.org/content/10.1101/2025.06.10.658886v1

submitted 10 days ago • 0 comments

A DNA part library for reliable engineering of the emerging model nematode symbiotic bacterium Xenorhabdus griffiniae HGB2511 https://www.biorxiv.org/content/10.1101/2025.06.09.658710v1

submitted 11 days ago • 0 comments

Single-cell characterization of bacterial optogenetic Cre recombinases https://www.biorxiv.org/content/10.1101/2025.06.06.658346v1

submitted 13 days ago • 0 comments

Engineering lung-sensing T cells using synthetic receptors targeting RAGE https://www.biorxiv.org/content/10.1101/2025.06.06.658315v1

submitted 13 days ago • 0 comments

A continuous landscape of signaling encodes a corresponding landscape of CAR T cell phenotype https://www.biorxiv.org/content/10.1101/2025.06.05.658149v1

submitted 15 days ago • 0 comments

An experimentally verified mechanistic model for predicting quorum sensing-based switches https://www.biorxiv.org/content/10.1101/2025.06.05.658036v1

submitted 15 days ago • 0 comments

Tuning viscoelasticity and fine structure of living materials via synthetic adhesion logic and rheological perturbations https://www.biorxiv.org/content/10.1101/2025.06.04.657808v1

submitted 16 days ago • 0 comments

Cell-free genome-wide transcriptomics through machine learning optimization https://www.biorxiv.org/content/10.1101/2025.06.04.657821v1

submitted 16 days ago • 0 comments

DNA framework array enables ultra-high throughput DNA synthesis https://www.biorxiv.org/content/10.1101/2025.05.30.657018v1

submitted 20 days ago • 0 comments

Unified Genomic and Chemical Representations Enable Bidirectional Bio-synthetic Gene Cluster and Natural Product Retrieval https://www.biorxiv.org/content/10.1101/2025.05.31.656985v1

submitted 20 days ago • 0 comments

DNA Flipping as Facile Mechanism for Transmembrane Signaling in Synthetic Cells https://www.biorxiv.org/content/10.1101/2025.05.31.656672v1

submitted 20 days ago • 0 comments

Carbon-Efficient Conversion through Hydrogen and Formate-Driven Metabolism in Escherichia coli https://www.biorxiv.org/content/10.1101/2025.05.30.657096v1

submitted 20 days ago • 0 comments

Changing the initiation unit of nonribosomal peptide synthetases to access underexplored biosynthetic potential https://www.biorxiv.org/content/10.1101/2025.05.29.656725v1

submitted 21 days ago • 0 comments

De novo design of hundreds of functional GPCR-targeting antibodies enabled by scaling test-time compute https://www.biorxiv.org/content/10.1101/2025.05.28.656709v1

submitted 21 days ago • 0 comments

Making deep mutational scanning accessible: a cost-efficient approach to construct barcoded libraries for genes of any length https://www.biorxiv.org/content/10.1101/2025.05.29.656836v1

submitted 22 days ago • 0 comments

Characterization of recombinase-based genetic parts and circuits using nanopore sequencing https://www.biorxiv.org/content/10.1101/2025.05.27.656450v1

submitted 23 days ago • 0 comments

Using domain insertion to create sulfite reductases that present chemical-dependent activities https://www.biorxiv.org/content/10.1101/2025.05.23.655854v1

submitted 28 days ago • 0 comments

When good guides go bad: empirical evaluation of all unique Cas9 targets in E. coli reveal widespread functionality and rules for gRNA biological design https://www.biorxiv.org/content/10.1101/2025.05.23.651106v1

submitted 28 days ago • 0 comments

Orchestrating Self-Replication in Artificial Cells through Digital Microfluidics https://www.biorxiv.org/content/10.1101/2025.05.23.655734v1

submitted 28 days ago • 0 comments

Combinatorial mutagenesis of N-terminal sequences reveals unexpected and expanded stability determinants of the Escherichia coli N-degron pathway https://www.biorxiv.org/content/10.1101/2025.05.22.655665v1

submitted 29 days ago • 0 comments

Peptide Barcodes for miRNA activity assessment in mammalian cells https://www.biorxiv.org/content/10.1101/2025.05.22.655559v1

submitted 29 days ago • 0 comments

Integration of strain and process optimization to increase autotrophic growth of engineered Komagataella phaffii https://www.biorxiv.org/content/10.1101/2025.05.21.655372v1

submitted 30 days ago • 0 comments

Unveiling the hidden window of prime editing https://www.biorxiv.org/content/10.1101/2025.05.20.655067v1

submitted 31 days ago • 0 comments

PYEAST - Python Enabled Automated Strain Transformaiton https://www.biorxiv.org/content/10.1101/2025.05.19.655004v1

submitted 31 days ago • 0 comments

Multiobjective learning and design of bacteriophage specificity https://www.biorxiv.org/content/10.1101/2025.05.19.654895v1

submitted 32 days ago • 0 comments

Engineered Acinetobacter baylyi ADP1-ISx cells are sensitive DNA biosensors for antibiotic resistance genes and a fungal pathogen of bats https://www.biorxiv.org/content/10.1101/2025.05.17.654686v1

submitted 33 days ago • 0 comments

Sequestration-Based Neural Networks That Operate Out of Equilibrium https://www.biorxiv.org/content/10.1101/2025.05.16.654484v1

submitted 34 days ago • 0 comments

Efficient CRISPR-Cas9-mediated genome editing of the cane toad (Rhinella marina) https://www.biorxiv.org/content/10.1101/2025.05.15.654396v1

submitted 35 days ago • 0 comments

A Saccharomyces boulardii synthetic biotic platform for delivery of therapeutic nanobodies to ameliorate gastrointestinal inflammation https://www.biorxiv.org/content/10.1101/2025.05.15.652971v1

submitted 35 days ago • 0 comments

Experimental Evaluation of AI-Driven Protein Design Risks Using Safe Biological Proxies https://www.biorxiv.org/content/10.1101/2025.05.15.654077v1

submitted 35 days ago • 0 comments