brookmans76.bsky.social - Profile | ThreadSky | a Reddit-style client for Bluesky

On my way back home from #ascoGU25 Great discussion yesterday by @ERPlimackMD of #CheckMate 274 / #NIAGARA in the context of perioperative + adjuvant immunotherapy in #bladdercancer @oncodaily.bsky.social @oncoalert.bsky.social

submitted 16 days ago • 0 comments

Updated analysis with additional FU of EV 302 EV+P in 1st line advanced #BladderCancer ✅ PFS & OS benefit in all groups ✅ Benefit in cisplatin eligible/ineligible ✅ Safety consistent with prior analysis ✅ mDOR close to 2 years #ascoGU25 @oncodaily.bsky.social

submitted 16 days ago • 0 comments

Great weekend with a 12 1/3 hrs indoor cycling race 🚴‍♂️🚴‍♀️🚴🚴 Great start into the 2025 season and after recovering from 2024 pelvic fracture

submitted 29 days ago • 1 comment

Just a beautiful weekend! As it should be…

submitted 37 days ago • 1 comment

Now published: This MA is the basis for our ongoing #ZMoveMent1 study evaluating the impact of endurance*resistance training on QoL, oncological outcomes, fitness in #ProstateCancee pts 👉 we still don’t use #PhysicalExercise in cancer pts in an optimal way 👉 www.mdpi.com/2072-6694/16...

submitted 47 days ago • 0 comments

Rethinking #ProstateBiopsy protocols: A systematic review (23 studies, 12,324 pts) shows that #AntibioticProhylaxis can safely be omitted in transperineal bx 💉w/o elevating infectious risks 🧫 #ProstateCancer #Urology #AntibioticStewardship @lucacindolo.bsky.social 👉 www.nature.com/articles/s41...

submitted 50 days ago • 1 comment

FDA Released Draft Guidance on Incorporating Tissue Biopsies in Clinical Trials @fda.gov oncodaily.com/insight/fda2... #Cancer #FDA #OncoDaily #Oncology #TissueBiopsy #Medicine #Health

submitted 51 days ago • 1 comment

#CREST trial with positive results for #PD-1 in HR #NMIBC! ✅The study evaluated #sasanlimab (PD-1i)+BCG vs standard #BCG (induction + maintenance) in BCG-naïve, HR NMIBC. ✅The study met its primary endpoint with significant improvement of EFS pfizer.com/news/press-rel… @oncodaily.bsky.social

submitted 51 days ago • 1 comment

Alcohol and Cancer Risk: The U.S. Surgeon General’s Advisory 2025 oncodaily.com/insight/218765 #AlcoholAndCancerRisk #Cancer #OncoDaily #Oncology #SurgeonGeneral’sAdvisory #Medicine #Health

submitted 52 days ago • 0 comments

Understanding emotions to enhance leadership 💡❤️‍🔥 @brookmans76.bsky.social led a powerful session on Emotional Intelligence — exploring how self-awareness, empathy, and human connection 🤝 can shape better leaders in healthcare 🌟. #EAUTalentIncubator

submitted 52 days ago • 0 comments

Moving from the dance floor 🕺💃 to the balcony 🏛️” - Great leadership requires both action & reflection. Insightful session by @brookmans76.bsky.social at #EAUTalentIncubator on finding balance in leadership! 👏✨ @uroweb.bsky.social #LeadershipDevelopment

submitted 53 days ago • 0 comments

New meta-analysis shows #PDE5 inhibitors, like tadalafil & sildenafil, may modestly reduce HbA1c levels in diabetes, with long-acting inhibitors having a greater impact. Promising dual benefit for managing diabetes & #erectiledysfunction. #Diabetes #PDE5 #HbA1c

submitted 56 days ago • 1 comment

Immunotherapy shows sex bias—men respond better; women face more severe AEs. Understanding sex hormones, chromosomes, and epigenetics in immunity could lead to tailored immuno-oncology strategies. #Cancer #Immunotherapy #Oncology @oncoalert.bsky.social rdcu.be/d49Mq

submitted 64 days ago • 0 comments

Gevorg Tamamyan’s first message as New POEM President @gevorgtamamyan.bsky.social oncodaily.com/blog/gevorg-... #Cancer #OncoDaily #Oncology #PediatricCancer #Medicine #PediatricCancerCare #PediatricOncology #Health #EastAndMediterraneanGroup #POEMGroup

submitted 70 days ago • 0 comments

Exercise improves quality of life for #ProstateCancer patients. Our latest systematic review shows combined resistance and aerobic training reduces fatigue, enhances mental and sexual health, and boosts fitness. Resistance training also improves body composition #ProstateCancer #PhysicalExercise

submitted 70 days ago • 1 comment

Feels good to realize I am back on @gozwift.bsky.social @zwiftrides.bsky.social to get up to 4 jerseys in one training. Rehab is now definitely over after my pelvic fracture 3 months ago #Roadbike #Cycling Back to real training and rides!

submitted 72 days ago • 3 comments

Genomic sequencing identified hereditary cancer risks in 9% of patients after uninformative gene panels. However, most findings lacked evidence-based guidelines. #Genomics #Cancer #Oncology @oncoalert.bsky.social @viveksubbiah.bsky.social @realbowtiedoc.bsky.social doi.org/10.1200/PO-2...

submitted 75 days ago • 0 comments

Also sharing the link to donation in memory and honor of Dr. Felix Feng here: ow.ly/Uc3H50TSBiC

submitted 80 days ago • 0 comments

It is such bad news - and an incredible loss. Felix Feng has been such a wonderful research partner. I will miss him and the great collaboration we had.

submitted 80 days ago • 0 comments

#Nectin4 in GU vs other malignancies ✅ Nectin4 is more prevalent in GU cancers than others ✅ still more data needed on the prognostic and predictive value 👉 Interested in more data on how prior treatment impacts Nectin4 + how this could impact treatment sequence @oncodaily.bsky.social #BladderCancer

submitted 86 days ago • 0 comments

Choose 20 books that have stayed with you or influenced you. One book per day for 20 days, in no particular order. No explanations, no reviews, just covers. #booksky 📚💙 #bookchallenge #20daybookchallenge 11/20

submitted 86 days ago • 1 comment

Impressive results: Ph 2 trial: BCG + gemcitabine in BCG-exposed #NMIBC (HG Ta/T1/CIS) ✅ 6 & 12 mo CR: 94% & 81% ✅ 6, 12 & 18 mo HG-RFS: 97%, 85%, 76% ✅ 2 Gr AEs (UTI, pneumonitis). No Gr 4,5 AEs Phase 3 trial vs BCG will follow #SUO24 #BladderCancer @oncodaily.bsky.social

submitted 87 days ago • 0 comments

Great updates from Patrick Hensley and Mark Tyson on the huge and growing array of options for non-muscle-invasive #bladdercancer #SUO24

submitted 88 days ago • 0 comments

Great talk indeed @joshmeeks.bsky.social and a very important aspect to be considered for future trials

submitted 87 days ago • 0 comments

Thank you @oncodaily.bsky.social Great honor to be on your list!

submitted 88 days ago • 1 comment

Frailty in older adults w/ #ProstateCancer is a significant challenge, as it can affect both the prognosis and treatment decisions. Frailty results from aging-related declines in physiological reserves and exacerbated by both ADT & the cancer itself, leading to sarcopenia & reduced bone density

submitted 91 days ago • 0 comments

He was and is an icon and legend #VirgilAbloh Thank you @oncodaily.bsky.social for remembering him I can also recommend reading his Abloh-isms

submitted 93 days ago • 0 comments

Life expectancy gaps in the US 🇺🇸 have widened—now over 20 years between groups. Geography, race, & income remain key drivers. 🌍 Globally, disparities may be even worse. Inequities demand urgent action. #HealthDisparities #Longevity #EquityInHealth @oncoalert.bsky.social @ptarantinomd.bsky.social

submitted 96 days ago • 0 comments

AI has a huge potential in #BladderCancer for diagnosis, prognostic and predictive assessment Some questions remain to be answered related to: ▶️ Heterogeneity of disease ▶️ Interreader variability of pathology assessment ▶️ Which ground truth to apply? #AI #MachineLearning @oncoalert.bsky.social

submitted 96 days ago • 0 comments

Interesting paper showing that #antibiotics may reduce cancer risk by depleting gut microbiota metabolizing nitrosamines #BladderCancer #Microbiome But (not discussed in the paper): 🚩AB can also disrupt beneficial microbial functions 🚩Increase cancer risk 🚩Negatively impact outcomes of IO therapy

submitted 97 days ago • 0 comments

Targeted tx for papillary RCC require tailored approaches, as enrichment strategies based solely on histology are insufficient, & selective inhibitors offer better tolerability. In met papillary RCC, VEGF- & MET-directed tx show efficacy, w/cabozantinib being a potential standard of care #RenalC24 🚨

submitted 97 days ago • 0 comments

She has 👉 @loebstacy.bsky.social

submitted 97 days ago • 0 comments

Great tool! Thank you @bsky.app @rose.bsky.team + independent developer of the searchable starter packs

submitted 97 days ago • 0 comments

Early detection of RCC faces unique challenges. As one of the lowest-shedding tumors with few recurrent mutations, genomic approaches remain limited. Novel cfDNA methylation profiling shows promise for non-invasive diagnosis, offering potential breakthroughs in precision medicine. #Oncology

submitted 99 days ago • 0 comments

EAU Talent Incubator Module 4 in Berlin was a great one again! Active participants, great topics #Policy #Innovation important for academic and non-academic urologists, and perfect network opportunity @uroweb.bsky.social @jlvasquez82.bsky.social

submitted 100 days ago • 2 comments

Declan Murphy discusses fast track queues at the Pearly Gates and doublet vs triplet therpy for mHSPC! Teaser for current GU Cast PROSPECT Part 2 #urology #podcast #prostatecancer

submitted 101 days ago • 1 comment

More information about Urology On Air coming soon... www.youtube.com/watch?v=XlVT...

submitted 104 days ago • 0 comments

Thank you for sharing @dunnedeirdre.bsky.social A great reminder to read this excellent paper

submitted 102 days ago • 0 comments

RADICALS-HD: Adding ADT to postop RT in prostate cancer shows no MFS improvement. Long-term outcomes remain favorable, even without ADT. High-risk cases need focus! @oncoalert.bsky.social DOI: 10.1016/j.eururo.2024.07.026

submitted 103 days ago • 2 comments

Just out: Our multicenter study comparing Uromonitor® DNA assay to #UrineCytology for #BladderCancer ✅ TERT & FGFR-3 mutations strongly predict UCB ❌ 93.3% specificity, but 49.3% sensitivity only ❌ KRAS mutations lacked predictive value. 🤔 The quest for optimal non-invasive #biomarker continues

submitted 103 days ago • 0 comments