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Fabulous talk at the Buck FRS today by speaker Dr David Walker, Professor of Integrative Biology and Physiology at UCLA. His talk was about molecular analysis of intestinal and brain aging. uclaibp

submitted 3 days ago • 0 comments

Learn how to be your own geriatrician! Buck was thrilled to partner with Vivalon this week providing valuable info to older adults on how to best advocate for themselves in a medical system that often lets them down. Kudos to Dr. John Newman! www.youtube.com/watch?v=-6A-... @geriscidoc.bsky.social

submitted 3 days ago • 0 comments

Five days of indulging in chocolate bars, crisps and other junk foods can lead to lingering changes in brain activity, a study shows1. The resulting brain patterns are similar to those seen in people who have obesity. https://go.nature.com/3F61B4o

submitted 6 days ago • 7 comments

An #autoimmune response involving #PINK1 may help explain why #Parkinsons is much more common in men. Study in @jclinical-invest.bsky.social shows men with PD had a 6-fold increase in PINK1-specific T cells; women with PD showed only a 0.7 increase. www.jci.org/articles/vie...

submitted 6 days ago • 0 comments

#Artificialsweetener aspartame triggers insulin spike leading to blood vessel inflammation and larger and more arterial plaques in mice. Study in @cellpress.bsky.social (Cell Metabolism) involved mice that ate the human equivalent of 3 cans of diet soda daily. www.sciencedirect.com/science/arti...

submitted 12 days ago • 0 comments

Our CEO, Eric Verdin answered questions about the administration’s proposed budget cuts to the NIH at a hearing before the Senate Special Committee on Aging this afternoon. Hear his exchange with Angela Alsobrook D-MD here: youtu.be/XrhHldez1AI

submitted 18 days ago • 0 comments

What else can #Ozempic and other #GLP1 receptor agonists do? Study in @jama.com shows the drugs have promise in reducing cravings for #alcohol and heavy drinking. An estimated 178,000 US deaths per year can be attributed to alcohol. jamanetwork.com/journals/jam...

submitted 19 days ago • 0 comments

Incubate at Buck! State-of-the-art lab & vivarium spaces are available for lease at Buck, one of the Bay's most renowned research destinations. Access to campus amenities, equipment, expertise, community and industry connections. km-ndp-media-repository.s3.us-west-2.amazonaws.com/kmconnect/LI...

submitted 19 days ago • 0 comments

11 of our 12 part Live Better Longer Community Seminar series is about Ovarian Aging and Women’s Health. Buck’s Dr. Jennifer Garrison is shedding light on why human ovaries age faster than other organs in women’s bodies and how that process has effect on overall health @jennifergarrison.bsky.social

submitted 26 days ago • 0 comments

Dr. Michelle Arkin from UCSF, Distinguished Professor in Pharmaceutical Chemistry, was invited by BWISE to give a seminar today. She talked about designing compounds to inhibit Caspase 6 activity to reduce tau toxicity in Alzheimer's disease.

submitted 30 days ago • 0 comments

#thymus gland, which plays crucial role in immunity, takes major hit from aging. Study in @cp-immunity.bsky.social identifies specific type of regulatory T cell that homes back into thymus and repairs damage. Mechanism works in aging mice. Hope for humans? www.cell.com/immunity/ful...

submitted 30 days ago • 0 comments

Diverse gut microbiomes protect against pathogens by blocking nutrient access, according to a 2023 Science study. The findings highlight why #microbiome diversity is important to human health. Learn more in this #SciencePerspective: scim.ag/40Pu6fk #ScienceMagArchives

submitted 33 days ago • 2 comments

A muscle patch developed using stem cells can help to repair failing hearts without adverse effects, according to a paper in Nature. #Medsky 🧪

submitted 32 days ago • 1 comment

The #exposome is all around us and it definitely impacts how well (or not) we age. Our latest blog introduces exposome and describes major project at Buck focused on identifying new mechanisms that allow these environmental factors to drive aging and disease www.buckinstitute.org/blog/using-b...

submitted 33 days ago • 0 comments

Register for our upcoming seminar, next Wed, Feb 5 - zoom or in-person. Ovarian Aging and Women’s Health with Dr. Jennifer Garrison. For women and the men who love them: register today! @jennifergarrison.bsky.social #womenshealth www.buckinstitute.org/events/live-...

submitted 33 days ago • 0 comments

Few medical options are typically presented to people going through menopause, but t outlook for managing it is now starting to change. A feature in Nature outlines the emerging therapies, which includes a relook at hormone replacement therapy. #Medsky 🧪

submitted 36 days ago • 5 comments

Protein aggregation plays role in bacterial dormancy. Study in @nature.com Communications shows disrupting process may lead to improved effectiveness of antibiotics and reduce incidence of persistent infections www.nature.com/articles/s41...

submitted 35 days ago • 0 comments

Can we blame mom for our aging brain? Study in mice in @nature.com shows when brain cells of females express only a maternal X chromosome memory and cognition deteriorate faster than in females that express both maternal and paternal X chromosomes. www.nature.com/articles/s41...

submitted 38 days ago • 0 comments

A new review describes basic and translational research on the complex physiological processes of hunger, which regulate feeding habits and are influenced by socioeconomic, cultural, and behavioral factors. Read the full review: nej.md/3C8CHAn #MedSky #GastroSky

submitted 39 days ago • 1 comment

Where do the dopamine hits does from? A new reward center in the brain is discovered (yes, single cell, spatial omics at work again) @science.org www.science.org/doi/10.1126/... www.science.org/doi/10.1126/...

submitted 39 days ago • 3 comments

Nature Reviews Drug Discovery reports that the FDA approved 50 new therapeutics in 2024, including approvals for a novel schizophrenia drug and the first NASH (non-alcoholic steatohepatitis) medicine. 🔒

submitted 38 days ago • 0 comments

Many age-related diseases involve fibrosis. Study in @geroscience.bsky.social shows mechanical forces shape #cellularsenescence and related secretory phenotypes. Researchers in Winer lab ID’d unique high-stiffness-driven secretory protein profiles link.springer.com/article/10.1...

submitted 39 days ago • 0 comments

The use of glucagon-like peptide 1 receptor agonists (GLP-1RAs) may be associated with a broad spectrum of health effects, including decreased risk for 42 health outcomes and increased risk of 19 health outcomes, according to a study in Nature Medicine. https://go.nature.com/3ClpHHx #Medsky 🧪

submitted 41 days ago • 2 comments

Reconciling 2 major explanations for #aging, study in Nature Aging @nature.com finds somatic mutations are fundamental driver of aging and #epigenetic changes simply track process. Reversing aging may be harder than previously thought. Time to rethink strategies? www.nature.com/articles/s43...

submitted 40 days ago • 0 comments

LRRK2 is a kinase whose activity is linked to #Parkinsons disease. New research from Bentley-DeSousa and @shawnferguson.bsky.social reveals converging roles of STING and #lysosome damage in activating LRRK2 at #lysosomes via interactions between LRRK2 and GABARAP. https://buff.ly/3DT8A02

submitted 47 days ago • 1 comment

A paper in Nature Food presents GroceryDB, a dataset with more than 50,000 food items sold at major grocery stores in the US that uses big data to provide information on processing—categorized by store, food category and price range. https://go.nature.com/3E7DMZu 🔒

submitted 46 days ago • 0 comments

Postmenopausal women are at increased risk for #osteoarthritis. Study in @nature.com Aging finds 17β-estradiol and progesterone loss increases senescence markers, matrix disassembly, and degeneration in mouse cartilage. Research could pave way for new therapies www.nature.com/articles/s43...

submitted 45 days ago • 0 comments

Psychological profiles are associated with the evolution of mental, cognitive and #brainhealth in middle-aged and older adults. Study in @natureportfolio.bsky.social (Nature Mental Health) identifies risk and protective factors for cognitive decline. www.nature.com/articles/s44...

submitted 46 days ago • 0 comments

Another packed house this morning at our 10th seminar in our Live Better Longer Community Seminar series. Today research on aging is the most interrogated field in all of the life sciences. Dr Verdin is addressing what’s next for the field, and how soon will we get there.

submitted 47 days ago • 0 comments

A study in Nature Aging finds that structural economic inequality is linked to reduced brain volume and connectivity in middle-aged and older adults across the Americas, more so in Alzheimer’s disease than in frontotemporal dementia. https://go.nature.com/4fRE2t6 🔒

submitted 49 days ago • 0 comments

Intermittent fasting inhibits human hair growth in randomized clinical trial. Study in @cellpress.bsky.social shows that regimens selectively induce apoptosis in activated hair stem cells by activating crosstalk between adrenal glands and dermal adipocytes in skin www.cell.com/cell/abstrac...

submitted 49 days ago • 0 comments

We’re thrilled that our 1st blog post of 2025 profiles Buck Prof Nathan Price, Co-Dir of Center for Human Healthspan. If you’re interested in how personalized, data-driven science will drive healthy aging and change medicine, this blog post is for you! www.buckinstitute.org/blog/faculty...

submitted 53 days ago • 0 comments

Long associated with aging, senescent cells can promote health and have physiological roles. Learn more in this #SciencePerspective: scim.ag/40tp4nx

submitted 54 days ago • 0 comments

A good night’s #sleep might literally clear your brain. Study in mice in @cellcellpress.bsky.social shows that norepinephrine plays a key role in this healthy “brain washing” of waste products and it highlights how popular sleep meds may disrupt the process. www.cell.com/cell/fulltex...

submitted 53 days ago • 0 comments

Study in @natureportfolio.bsky.social estimates that 2.2 million new cases of #type2diabetes and 1.2 million new cases of #cardiovasculardisease occur each year globally due to consumption of sugar-sweetened beverages. Map does not bode well for USA. www.nature.com/articles/s41...

submitted 55 days ago • 0 comments

Approximately one in 10 new cases of type 2 diabetes and one in 30 new cases of cardiovascular disease worldwide in 2020 may be attributable to the consumption of sugar-sweetened beverages, according to a study in Nature Medicine. https://go.nature.com/4h0ZJrn 🧪

submitted 56 days ago • 2 comments

Researchers have shown potential link between loneliness and certain proteins in the body. Study in @natureportfolio.bsky.social involved data from 42000 people. 175 proteins were linked to social isolation, half of them were linked to #heartdisease and #type2diabetes www.nature.com/articles/s41...

submitted 56 days ago • 0 comments

2025 may be the year (finally) when women’s health begins to get its due, and our Center for Healthy Aging in Women is leading the way. Check it out and thanks to Nob Hill Gazette for spreading the word. @jennifergarrison.bsky.social #womenshealth www.nobhillgazette.com/people/cause...

submitted 59 days ago • 0 comments

Not all cell types in the brain age in the same way. Study in mice in @natureportfolio.bsky.social provides a roadmap for how aging may alter genetic activity in different cells, providing a potential guide for developing new treatments www.nature.com/articles/s41... #brainaging

submitted 60 days ago • 0 comments

Shout out to Buck professor Malene Hansen and SAB chair Ana-Maria Cuervo and their colleagues on this important initiative www.nature.com/articles/s41... @natureportfolio.bsky.social (Nature Cell Biology)

submitted 72 days ago • 0 comments

Thrilled to announce up to $52M award from ARPA_H for groundbreaking PATH program: Personalized Analytics for Transforming Health. Along with our strategic partner Phenome Health our aim is to predict and prevent diseases to increase individual #healthspan. www.buckinstitute.org/news/buck-in...

submitted 74 days ago • 0 comments

What if #aging is a developmental stage sparked by specific molecular cues? Study in @science.org shows that certain cell populations change in every organ both at the same time and in the same way, similar to how leaves drop when the weather changes www.science.org/doi/10.1126/...

submitted 75 days ago • 0 comments

New in The Innovation Life! Single-cell analysis reveals conserved regulons shaping muscle stem cell behavior during development and aging in mammals. This study contribute to our understanding of muscle health. Read more doi.org/10.59717/j.x... #lifesciences #genomics #scrnaseq #aging #Research

submitted 79 days ago • 1 comment

Circadian rhythms regulate #inflammation. Study in FASEB Journal describes how macrophages work differently through day & could lead to time-targeted treatments for inflammatory disease like #arthritis. Work focused on mitochondria & inflammasome NLRP3 faseb.onlinelibrary.wiley.com/doi/10.1096/...

submitted 76 days ago • 1 comment

Bugs in our gut may be prompting us to reach for another donut. Study in @natureportfolio.bsky.social shows Microviridae bacteriophages influence food addictions & obesity by modulating tryptophan & tyrosine metabolism & are linked to serotonin and dopamine metabolism. x.com/NatMetabolis...

submitted 77 days ago • 0 comments

The gut-brain connection is implicated in both #Alzheimers and #Parkinsons disease. Postdocs at the Buck are studying how metabolites in our microbiome, which can become imbalanced with age, influence both diseases. Details in our latest blog post. www.buckinstitute.org/blog/the-gut...

submitted 81 days ago • 0 comments

Did you know that you can save on your taxes while also supporting Buck’s mission to end threat of age-related diseases? Rolling over your required minimum distribution (RMD) from your IRA to the Buck renders the distribution tax free and reduces your taxable income. Dec 31 will be here soon!

submitted 89 days ago • 0 comments

Excited to once again host the annual Longevity Summit at a time of unprecedented advances in our field! #Livebetterlonger

submitted 90 days ago • 1 comment

Take a listen! Our very own Gordon Lithgow highlights the how’s and why’s of research on aging and talks about the progress being made in extending #healthspan, in a podcast aptly named “Not born yesterday.” podcasts.apple.com/us/podcast/e...

submitted 90 days ago • 0 comments

#Ketone bodies are not just about energy. Study in @cellpress.bsky.social shows metabolites are powerful signaling molecules that help clean up damaged proteins. New biology for aging and neurodegenerative disease @geriscidoc.bsky.social @sidmadhavan.bsky.social www.buckinstitute.org/news/ketone-...

submitted 91 days ago • 0 comments