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cflabsresearch.bsky.social
Chordoma Foundation's patient driven research laboratory 100% dedicated to accelerating cures for chordoma.
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For all the gains AI affords in compound design and discovery, experimental validation still remains a bottleneck. But we're making that part easy for the cancer target TBXT with a suite of biophysical, in vitro and in vivo assay capabilities—plus prizes for potent binders: tbxtchallenge.org

submitted 5 days ago • 0 comments

📰 Prof Paul Workman, our former CEO, along with his team in our Centre for Cancer Drug Discovery, have made a breakthrough that could lead to new drugs for #chordoma — a rare #BoneCancer that led to the death of his mother. Read more in @theguardian.com ⤵️ www.theguardian.com/science/2025...

submitted 12 days ago • 3 comments

Crucial building blocks for drugging TBXT (brachyury) published by @ox.ac.uk @icr.ac.uk @uncchapelhill.bsky.social team including crystal structure, discovery of ligandable pockets, and compounds that could serve as starting points for inhibitors or degraders www.nature.com/articles/s41...

submitted 12 days ago • 2 comments

#chemsky & #compchem peeps, we need your help drugging a difficult target: TBXT (brachyury), a transcription factor critical for our disease, chordoma, and implicated in other cancers. We can offer enabling resources, free SPR analysis and now $500K+ in prizes for TBXT ligands: tbxtchallenge.org

submitted 48 days ago • 2 comments

#chemsky & #compchem peeps, we need your help drugging a difficult target: TBXT (brachyury), a transcription factor critical for our disease, chordoma, and implicated in other cancers. We can offer enabling resources, free SPR analysis and now $500K+ in prizes for TBXT ligands: tbxtchallenge.org

submitted 48 days ago • 2 comments

Our team recently attended the Connective Tissue Oncology Society (CTOS) annual meeting and presented on three areas of ongoing research in the lab: targeting replication stress, biomarkers of EGFR inhibitor sensitivity, and capabilities to enable TBXT (brachyury) drug discovery. 🧵

submitted 83 days ago • 1 comment

Nice work from @dkfz.bsky.social defining TBXT regulome.

submitted 100 days ago • 0 comments

Building on recent findings that GPX4 is a genetic essentiality in chordoma, we’ve demonstrated that GPX4 inhibition induces ferroptotic cell death, suggesting #ferroptosis susceptibility may be a targetable vulnerability in chordoma. Results now on Figshare: figshare.com/articles/fig...

submitted 100 days ago • 0 comments

Confirmed our recent observation of synergism between gemcitabine and ATR inhibition in two additional cell lines, latest data now on Figshare figshare.com/articles/fig...

submitted 102 days ago • 0 comments

We're studying replication stress in chordoma, and have recently identified several therapeutic approaches that exploit this vulnerability. Here are 3 new figures we’ve put on Figshare to enable others to build on our findings before they’re published. 👇

submitted 188 days ago • 1 comment

Hi! We're joining @bsky.app from Twitter. Our feed there is at x.com/CFLabsResearch. We're here to share recent developments from our lab and from the broader chordoma research field, as well as to connect with and learn from others with overlapping research interests/expertise.

submitted 188 days ago • 0 comments