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charlesbj.bsky.social
Investigating protein nanomachines and their dynamics. ARC DECRA Fellow at Monash University 🇦🇺. Structural biologist. Author of WIGGLE. He/Him. 🏳️‍🌈
334 posts 1,325 followers 847 following
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Hot days (and grid atlases) are for a cold knock off beer... 🍻

submitted 1 day ago • 0 comments

Injecting arbitrary experimental data into AlphaFold has been a missing feature. With high-throughput crystallography yielding 1000s of structures/year (@covid_moonshot) & cryoET making 😍 but low-res in situ models, it's also become a necessary one for scaling up structural biology. Hence ROCKET👇!

submitted 3 days ago • 2 comments

I've decided to start posting more mundane stuff to try and dilute some of the doom scrolling. Enjoying a bruschetta snack, nice view, and cucumber and yuzu G&T. Cheers.

submitted 3 days ago • 2 comments

Do you like the beaches hot and your electron microscopy cold? 👇

submitted 8 days ago • 0 comments

Very happy to share our protocol for pair correlation microscopy of intracellular molecular transport. Congratulations @julissasv.bsky.social and thanks to Enrico, @digmanlab.bsky.social, Francesco, Ash! www.nature.com/articles/s41...

submitted 18 days ago • 0 comments

I am very happy to share our latest work on the detailed cryo-EM structure of the NDH-PSI supercomplex of spinach. Thanks to Werner Kühlbrandt, Alex Hahn and @mpibp.bsky.social ! 🍃❄️🔬 You can find the paper in open access in Nature Structural and Molecular Biology: www.nature.com/articles/s41...

submitted 31 days ago • 4 comments

🚨 Save the Date! 🚨 I'm thrilled to announce the Prato Conference on Pore Forming Proteins, happening this June in the stunning city of Prato, Italy! 🙏 Please share or repost this to help us reach as many people as possible—especially those who would love to attend!

submitted 41 days ago • 2 comments

"PhD enrollments decline in Australia as economic pressures discourage prospective students." Nearly three-quarters of University of Melbourne graduate students said food security was their top concern.

submitted 41 days ago • 1 comment

@dtegunov.bsky.social @dabiophysicist.bsky.social ... just casually following your discussion and this popped up. Worth testing for tilt series alignment? zju3dv.github.io/MatchAnything/

submitted 43 days ago • 1 comment

👋 #teamtomo Has anyone managed to compile stopgap from src? I'm a noob at MATLAB... Trying to debug and troubleshoot, but can't recompile edited code, so not making much progress 😅... #cryoET #cryoEM

submitted 50 days ago • 0 comments

Bier, Brot, und Wurst. 😍 Prost! Happy holidays.

submitted 58 days ago • 1 comment

How proximal is proximity labeling❓ Using DNA nanorulers we found that TurboID/BioID are largely contact labeling, while APEX2 also bears a major contact labeling pathway in parallel with diffusive labeling. www.biorxiv.org/content/10.1... Special thanks to @aliceyting.bsky.social for discussions

submitted 70 days ago • 2 comments

Unicore identifies single-copy protein structures across genomes using Foldseek, bypassing slow structure predictions by utilizing 3Di predictions from ProstT5, enabling rapid phylogenetic inference at the tree-of-life scale. 1/n 📄 www.biorxiv.org/content/10.1... 💾 github.com/steineggerla...

submitted 66 days ago • 2 comments

🎄 xmas preprint 🎄 we are excited to share our cryo-EM structure of UBR4 in complex with KCMF1 and CALM1. the PQC ligase forms a massive ubiquitination arena, primed to amplify ubiquitin chains (E4 activity) and boost degradation of defective proteins. www.biorxiv.org/content/10.1...

submitted 68 days ago • 4 comments

1/ Thrilled to announce Dr. Elizabeth Wright as the inaugural winner of the June Almeida Award for #cryoem! 🎉Elizabeth’s pioneering work in both cryo-ET methods and structural virology made her a perfect fit for this award. Congrats, Elizabeth!

submitted 71 days ago • 1 comment

👋 #skybrain, can anyone point me to useful resources for common non-canonical/non-natural amino acids? I'm looking for a collated summary of ncAA with descriptions of their uses/applications. I've exhausted google... #biochemistry #proteins

submitted 72 days ago • 2 comments

High-resolution template matching of the human ribosome in situ by Lippincott-Schwartz Lab @hhmijanelia.bsky.social @hhmi.bsky.social. >40 conformations within together reveal molecular dynamics of the elongation cycle with previously unknown bending and “spring-like” motion.

submitted 86 days ago • 1 comment

Putting all conference organisers on notice - this is how spaced posters should be... Think *accessibility*. But also, people actually need room to stand beside their poster and present it without inconveniencing their neighbouring colleagues.

submitted 78 days ago • 2 comments

Super excited to preprint our work on developing a Biomolecular Emulator (BioEmu): Scalable emulation of protein equilibrium ensembles with generative deep learning from @msftresearch.bsky.social ch AI for Science. www.biorxiv.org/content/10.1...

submitted 83 days ago • 22 comments

The PDBs for our TSC structure are now available! To put the size of TSC in perspective, here's a ribosome... this thing is enormous. 🤩 #cryoEM #mTORC1 #TSC rcsb.org/3d-view/9CE3 science.org/doi/10.1126/sciadv.adr5807 @luptoncj.bsky.social

submitted 82 days ago • 1 comment

Scalable emulation of protein equilibrium ensembles with generative deep learning www.biorxiv.org/content/10.1... No code is available yet, but sounds huge. Effectively does MD-sim, but fast!

submitted 83 days ago • 0 comments

We’ve had nearly 3 years of review, review, review. We need reviews, but it’s blindingly obvious that Australian research needs much greater Government investment while those reviews are done. This was true 3 years ago. Still true now. By @drjr.bsky.social

submitted 90 days ago • 3 comments

We’re excited to release a major update to the Boltz repo: v0.3.0. This release contains several important new features, including our confidence model and memory-efficient inference. Give it a try! github.com/jwohlwend/bo...

submitted 91 days ago • 2 comments

The CO2 crisis slides are really good, I knew capture wasn't particularly effective - but geeez.

submitted 91 days ago • 1 comment

You hear about our successes a lot on here, but I don't talk enough about the rejections. As of today, 10 out of the 12 grants members of our lab put in this year didn't get up. Most grants were led by early-career researchers in/with our team as a way for them to lead independent programs. 1/3

submitted 93 days ago • 2 comments

Did someone mix up AM and PM over at the #NHMRC? I'm all for releasing grant outcomes as soon as possible, but 1:30 AM is a rather unconventional choice!

submitted 93 days ago • 2 comments

🚨 Our story on the TSC:WIPI3 lysosomal-recruitment complex is now live in Science Advances. Equal-first co-authors @luptoncj.bsky.social & Laura D'Andrea. Work lead by @drellisdon.bsky.social. Funding from @deptofdefense.bsky.social & Australian Research Council. www.science.org/doi/10.1126/...

submitted 98 days ago • 5 comments