charlesdanko.bsky.social - Profile | ThreadSky | a Reddit-style client for Bluesky

Yikes. That Trump economy is really starting to shine.

submitted 3 days ago • 0 comments

Slava Ukraini! 🇺🇦

submitted 3 days ago • 0 comments

Accurate de novo transcription unit annotation from run-on and sequencing data @charlesdanko.bsky.social www.biorxiv.org/content/10.1...

submitted 9 days ago • 0 comments

My hot take: Universities and medical centers need to get MUCH better at outreach and explaining the benefits of funding independent research to the public.

submitted 22 days ago • 2 comments

www.biorxiv.org/content/10.1... Another genomic FM benchmark 💀

submitted 30 days ago • 1 comment

I wanted to write briefly about a very pleasant experience we recently had coordinating and collaborating closely on competing publications with 2 other teams. 1/

submitted 38 days ago • 2 comments

We wrote an opinion article inspired by the recent exciting reports on the sequence determinants of TSS selection + old observations on TFs activation domains. More posts on this soon! Q-rich activation domains: flexible ‘rulers’ for transcription start site selection? www.cell.com/trends/genet...

submitted 85 days ago • 0 comments

Brief thread on our opinion article "Q-rich activation domains: flexible ‘rulers’ for transcription start site selection?". Transcription people are surely aware of the important reports on the DNA sequence determinants of start site (TSS) selection in the human genome that came out this year. 1/15

submitted 72 days ago • 2 comments

Latest from our lab: Training sequence-to-function models using matched genome sequence and functional data improves performance in variant interpretation tasks. Congrats to Adam He and Nathan Palamuttam on getting this out. www.biorxiv.org/content/10.1...

submitted 136 days ago • 0 comments

RNA polymerases reshape chromatin and coordinate transcription on individual fibers www.biorxiv.org/content/10.1...

submitted 425 days ago • 0 comments

I just sent my congressman a strong letter supporting Ukraine aid. Please consider doing the same!

submitted 452 days ago • 0 comments

Beautiful work from Effie Apostolou' lab. www.nature.com/articles/s41...

submitted 454 days ago • 0 comments

Important thread.

submitted 480 days ago • 0 comments

Antisemitic threats are disgusting. I am heartbroken to hear about this happening in our community. www.cnn.com/2023/10/29/u...

submitted 490 days ago • 0 comments

New preprint by Sonny Arora and Jianyu Yang in our lab, in collab with Frank Pugh & lab, Minoru Ko, and Tomohiko Akiyama. We started with a simple question: are all Fox TFs pioneer factors? We investigated with the help of ChIP-exo and neural networks. 1/n www.biorxiv.org/content/10.1...

submitted 492 days ago • 1 comment

This looks very interesting. 🧬🔄🧬

submitted 492 days ago • 0 comments

Interesting new preprint from Corri Sept & Martin Aryee et al. combines MNase HiChIP for CTCF with new FactorFinder algorithm to profile 3D interactions conditional on CTCF being bound. Nice insights in loop extrusion from the perspective of CTCF-anchored cohesin www.biorxiv.org/content/10.1...

submitted 497 days ago • 1 comment

Fellow Ithaca: Our congressman Marc Molinaro is considering voting for Speaker Jordan. Consider sending a letter stating how you feel about this. Contact here: molinaro.house.gov/contact/ Afair, Our district is no longer safe red. Molinaro will have to win a wider swath of us to keep his seat.

submitted 503 days ago • 1 comment

Happy to share our latest preprint -- we built an integrated compendium of all publicly available human gut microbiome 16S data (~168,000 samples) and used it to explore patterns of microbiome variation around the world www.biorxiv.org/content/10.1...

submitted 503 days ago • 2 comments

new paper from the Luger Lab Parpers - collaboration with Dan LaBarbera's group at CU AMC Center for Drug Discovery, and funded by an ABNexus grant that should foster collaborations between CU Anschuetz and Boulder. i think it did just that! Congrats team Parp! www.sciencedirect.com/science/arti...

submitted 503 days ago • 0 comments

Fellow Ithaca: Our congressman Marc Molinaro is considering voting for Speaker Jordan. Consider sending a letter stating how you feel about this. Contact here: molinaro.house.gov/contact/ Afair, Our district is no longer safe red. Molinaro will have to win a wider swath of us to keep his seat.

submitted 503 days ago • 1 comment

New evidence for a higher-order chromatin organization in which distant TADs form large domains. www.cell.com/cell/fulltex...

submitted 509 days ago • 0 comments

finally our manuscript describing the weird and wonderful binding mode of a bacterial histone is online. www.nature.com/articles/s41...

submitted 511 days ago • 3 comments

Colors getting close to peak.

submitted 513 days ago • 1 comment

Hi Bluesky - happy to be here!!

submitted 516 days ago • 1 comment

@charlesdanko.bsky.social thanks for making me almost as cool as you!!

submitted 516 days ago • 2 comments

New faculty position in Gene Regulation at Penn State! Come join the fantastic collaborative environment in the Center for Eukaryotic Gene Regulation ( www.cegr.psu.edu )! Review of applications starts Nov. 1st 🧪🧬🔄🖥️ psu.wd1.myworkdayjobs.com/en-US/PSU_Ac...

submitted 517 days ago • 0 comments

CC gene regulation community. 🔄🧬🔄 bsky.app/profile/char...

submitted 518 days ago • 0 comments

cBAF genomic targeting relies on the IDR. Looks like a very nice paper that begins to work out some of the amino acids involved. www.cell.com/cell/fulltex...

submitted 518 days ago • 0 comments

What's the over/ under on this pushing back the Oct 5 NIH deadline?!

submitted 523 days ago • 0 comments