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Optogenetic vagal nerve stimulation attenuates heart failure by limiting the generation of monocyte-derived inflammatory CCRL2+ macrophages: @cp-immunity.bsky.social www.cell.com/immunity/ful...

submitted 3 hours ago • 0 comments

Early discounted registration ends June 27th for #CSNeuroimmune25, Sept 7–9, NYC! Explore cutting-edge #neuroimmunology and engage with experts in the field. Keynotes: David Julius & Susan Kaech hubs.li/Q03qS95l0 @cp-neuron.bsky.social @kavithascranton.bsky.social @cellpress.bsky.social

submitted 1 day ago • 0 comments

New research in @cp-immunity.bsky.social finds that heterozygosity for Crohn's disease risk allele of ATG16L1 promotes unique protein interactions & protects against bacterial infection ft. Brittany Miller, Isabel Vargas & @cadwelllab.bsky.social (@PennGIHep) www.sciencedirect.com/science/arti...

submitted 1 day ago • 1 comment

Journal Club Time📰: A new publication from @cp-immunity.bsky.social showed that therapy-induced tumor and non-tumor cells actively released mtDNA into the extracellular environment, which resulted in enhanced immunosuppressive activity of polymorphonuclear myeloid-derived suppressor cells.

submitted 1 day ago • 0 comments

"A rare genetic mutation known as APOE3-R136S, or the “Christchurch mutation,” appears to protect against #AlzheimersDisease by suppressing inflammatory signaling in the brain’s immune cells." Learn More in Immunity @cellpress.bsky.social www.cell.com/immunity/abs...

submitted 2 days ago • 1 comment

DOCK8 in T cells promotes Th17 and Treg cell functionality to restrain mucosal mast cells and limit susceptibility to oral anaphylaxis @cp-immunity.bsky.social www.cell.com/immunity/ful...

submitted 2 days ago • 0 comments

Compromised generation of functional CD8 T memory in absence of CD4 T cell help is not permanent but rather a transient state of delayed memory maturation www.cell.com/immunity/ful... @cp-immunity.bsky.social

submitted 2 days ago • 0 comments

So proud to share my first first-author paper from my postdoc in @liganlab.bsky.social out yesterday in @cp-immunity.bsky.social! We characterized a model of the APOE3 Christchurch mutation on a tauopathy background and found downregulation of cGAS-STING-IFN pathway as a source of protection!

submitted 3 days ago • 1 comment

🚨Our new paper is out!🚨 We uncover a protective mechanism of the rare APOE3 Christchurch (R136S) mutation against tauopathy—by suppressing microglial cGAS–STING–interferon (IFN) pathway, a key inflammatory axis triggered by tau. www.sciencedirect.com/science/arti...

submitted 3 days ago • 3 comments

Explore breakthroughs in #cancer #immunology with global leaders. #CellSymposia: The cancer-immunity cycle Keynotes: Ira Mellman & Carl June Abstract submission deadline: July 25 Sitges, Spain | Nov 2–4, 2025 http://dlvr.it/TLX7WS

submitted 3 days ago • 0 comments

Beautiful new work from Maz Divangahi lab about the enhanced anti-tumoral activity of β-glucan + BCG trained neutrophils leading to tumor eradication. #freshoffthepress @cp-immunity.bsky.social

submitted 3 days ago • 0 comments

Transcription factor T-bet regulates the maintenance and differentiation potential of lymph node and lung effector memory B cell subsets @cp-immunity.bsky.social www.cell.com/immunity/ful...

submitted 5 days ago • 0 comments

Combining BCG with β-glucan reprograms granulopoiesis to generate trained neutrophils with enhanced antitumoral activity, preventing their protumoral conversion and leading to complete tumor eradication @cp-immunity.bsky.social www.cell.com/immunity/ful...

submitted 4 days ago • 0 comments

The R136S mutation in the APOE3 gene confers resilience against tau pathology via inhibition of the cGAS-STING-IFN pathway @cp-immunity.bsky.social www.cell.com/immunity/ful...

submitted 3 days ago • 0 comments

Meet the keynote speakers at #CSNeuroimmune25: David Julius (UCSF) & Susan Kaech (The Salk Institute) NYC | Sept 7–9, 2025 Early registration discount ends June 27! hubs.li/Q03sQJjj0 @tcellogic.bsky.social @cp-neuron.bsky.social @salkinstitute.bsky.social #neuroimmune

submitted 6 days ago • 0 comments

Congratulations to the lab of IMP faculty member Greg Sonnenberg on this latest study showing STING in ILC3 can mediate immune tolerance, published this week in @cp-immunity.bsky.social

submitted 8 days ago • 0 comments

A conserved immune dysregulation signature is associated with infection severity, risk factors prior to infection, and treatment response @cp-immunity.bsky.social www.cell.com/immunity/ful...

submitted 10 days ago • 0 comments

Our new paper out this week shows that antibodies don’t just get better at what they already recognize—turns out they can learn something entirely new. This expands how we think about the adaptive immune system’s creative potential. #Immunology #Bcells #SHM #AffinityBirth #AntibodyEvolution

submitted 49 days ago • 0 comments

Our new Immunity paper is in print—and that an oil painting I made was chosen for the cover 😊 It visualizes “affinity birth,” the generative force of SHM creating new antibody specificities beyond V(D)J. #Immunology #AffinityBirth #SciArt #Bcells #SHM

submitted 17 days ago • 2 comments

Check out our June issue! Cover is an oil-on-canvas painting by Duane Wesemann ‪depicting the concept of "affinity birth" as a rising sun, with vibrant rays radiating outward as spectral representations of newly generated affinities ‪@affinityborn.bsky.social‬ www.cell.com/immunity/iss...

submitted 10 days ago • 0 comments

Nociceptor-derived CGRP enhances dermal type I conventional dendritic cell function to drive autoreactive CD8+ T cell responses in vitiligo. @cp-immunity.bsky.social www.cell.com/immunity/ful...

submitted 11 days ago • 0 comments

ILC3s are a RORγt+ APC that sense the microbiota through STING to induce microbiota-specific Treg cells www.cell.com/immunity/ful... @cp-immunity.bsky.social

submitted 11 days ago • 1 comment

Nociceptor-derived CGRP strengthens cDC1-CD8+ T cell interactions, leading to melanocyte destruction and white patches in vitiligo www.cell.com/immunity/ful... @cp-immunity.bsky.social

submitted 11 days ago • 0 comments

Structures of butyrophilin multimers reveal a plier-like mechanism for Vγ9Vδ2 T cell receptor activation #gdTcells @cp-immunity.bsky.social

submitted 14 days ago • 0 comments

It was a huge pleasure to write this spotlight commentary together with @inflammasomelab.bsky.social and @JaredCoombs on the recent Cell paper of Xingbin Hu lab on spectosis in red blood cells! Congrats to all the authors for their novel and elegant study in discovery miniNLRP3 signaling in RBC 👇

Optogenetic vagal nerve stimulation attenuates heart failure by limiting the generation of monocyte-derived inflammatory CCRL2+ macrophages: @cp-immunity.bsky.social www.cell.com/immunity/ful...

Online now: Optogenetic vagal nerve stimulation attenuates heart failure by limiting the generation f monocyte-derived inflammatory CCRL2+ macrophages

Early discounted registration ends June 27th for #CSNeuroimmune25, Sept 7–9, NYC! Explore cutting-edge #neuroimmunology and engage with experts in the field. Keynotes: David Julius & Susan Kaech hubs.li/Q03qS95l0 @cp-neuron.bsky.social @kavithascranton.bsky.social @cellpress.bsky.social

New research in @cp-immunity.bsky.social finds that heterozygosity for Crohn's disease risk allele of ATG16L1 promotes unique protein interactions & protects against bacterial infection ft. Brittany Miller, Isabel Vargas & @cadwelllab.bsky.social (@PennGIHep) www.sciencedirect.com/science/arti...

Online now: Diet-derived LPS determines intestinal IgA induction and repertoire characteristics independently of the microbiota

Journal Club Time📰: A new publication from @cp-immunity.bsky.social showed that therapy-induced tumor and non-tumor cells actively released mtDNA into the extracellular environment, which resulted in enhanced immunosuppressive activity of polymorphonuclear myeloid-derived suppressor cells.

"A rare genetic mutation known as APOE3-R136S, or the “Christchurch mutation,” appears to protect against #AlzheimersDisease by suppressing inflammatory signaling in the brain’s immune cells." Learn More in Immunity @cellpress.bsky.social www.cell.com/immunity/abs...

Online now: DOCK8 in T cells promotes Th17 and Treg cell functionality to restrain mucosal mast cells and limit susceptibility to oral anaphylaxis

DOCK8 in T cells promotes Th17 and Treg cell functionality to restrain mucosal mast cells and limit susceptibility to oral anaphylaxis @cp-immunity.bsky.social www.cell.com/immunity/ful...

Compromised generation of functional CD8 T memory in absence of CD4 T cell help is not permanent but rather a transient state of delayed memory maturation www.cell.com/immunity/ful... @cp-immunity.bsky.social

Online now: Prolonged but finite antigen presentation promotes reversible defects of “helpless” memory CD8+ T cells

So proud to share my first first-author paper from my postdoc in @liganlab.bsky.social out yesterday in @cp-immunity.bsky.social! We characterized a model of the APOE3 Christchurch mutation on a tauopathy background and found downregulation of cGAS-STING-IFN pathway as a source of protection!

🚨Our new paper is out!🚨 We uncover a protective mechanism of the rare APOE3 Christchurch (R136S) mutation against tauopathy—by suppressing microglial cGAS–STING–interferon (IFN) pathway, a key inflammatory axis triggered by tau. www.sciencedirect.com/science/arti...

Online now: Targeting Degradation of the Transcription Factor C/EBPβ Reduces Lung Fibrosis by Restoring Activity of the Ubiquitin-Editing Enzyme A20 in Macrophages

Explore breakthroughs in #cancer #immunology with global leaders. #CellSymposia: The cancer-immunity cycle Keynotes: Ira Mellman & Carl June Abstract submission deadline: July 25 Sitges, Spain | Nov 2–4, 2025 http://dlvr.it/TLX7WS

Beautiful new work from Maz Divangahi lab about the enhanced anti-tumoral activity of β-glucan + BCG trained neutrophils leading to tumor eradication. #freshoffthepress @cp-immunity.bsky.social

Transcription factor T-bet regulates the maintenance and differentiation potential of lymph node and lung effector memory B cell subsets @cp-immunity.bsky.social www.cell.com/immunity/ful...

Combining BCG with β-glucan reprograms granulopoiesis to generate trained neutrophils with enhanced antitumoral activity, preventing their protumoral conversion and leading to complete tumor eradication @cp-immunity.bsky.social www.cell.com/immunity/ful...

The R136S mutation in the APOE3 gene confers resilience against tau pathology via inhibition of the cGAS-STING-IFN pathway @cp-immunity.bsky.social www.cell.com/immunity/ful...

Online now: A fungal-derived adjuvant amplifies the antitumoral potency of Bacillus Calmette-Guérin via reprogramming granulopoiesis

Online now: The R136S mutation in the APOE3 gene confers resilience against tau pathology via inhibition of the cGAS-STING-IFN pathway

Online now: Transcription factor T-bet regulates the maintenance and differentiation potential of lymph node and lung effector memory B cell subsets

Meet the keynote speakers at #CSNeuroimmune25: David Julius (UCSF) & Susan Kaech (The Salk Institute) NYC | Sept 7–9, 2025 Early registration discount ends June 27! hubs.li/Q03sQJjj0 @tcellogic.bsky.social @cp-neuron.bsky.social @salkinstitute.bsky.social #neuroimmune

Congratulations to the lab of IMP faculty member Greg Sonnenberg on this latest study showing STING in ILC3 can mediate immune tolerance, published this week in @cp-immunity.bsky.social

A conserved immune dysregulation signature is associated with infection severity, risk factors prior to infection, and treatment response @cp-immunity.bsky.social www.cell.com/immunity/ful...

Online now: A conserved immune dysregulation signature is associated with infection severity, risk factors prior to infection, and treatment response

Our new paper out this week shows that antibodies don’t just get better at what they already recognize—turns out they can learn something entirely new. This expands how we think about the adaptive immune system’s creative potential. #Immunology #Bcells #SHM #AffinityBirth #AntibodyEvolution

Our new Immunity paper is in print—and that an oil painting I made was chosen for the cover 😊 It visualizes “affinity birth,” the generative force of SHM creating new antibody specificities beyond V(D)J. #Immunology #AffinityBirth #SciArt #Bcells #SHM

Check out our June issue! Cover is an oil-on-canvas painting by Duane Wesemann ‪depicting the concept of "affinity birth" as a rising sun, with vibrant rays radiating outward as spectral representations of newly generated affinities ‪@affinityborn.bsky.social‬ www.cell.com/immunity/iss...

Nociceptor-derived CGRP enhances dermal type I conventional dendritic cell function to drive autoreactive CD8+ T cell responses in vitiligo. @cp-immunity.bsky.social www.cell.com/immunity/ful...

ILC3s are a RORγt+ APC that sense the microbiota through STING to induce microbiota-specific Treg cells www.cell.com/immunity/ful... @cp-immunity.bsky.social

Nociceptor-derived CGRP strengthens cDC1-CD8+ T cell interactions, leading to melanocyte destruction and white patches in vitiligo www.cell.com/immunity/ful... @cp-immunity.bsky.social

Online now: Nociceptor-derived CGRP enhances dermal type I conventional dendritic cell function to drive autoreactive CD8+ T cell responses in vitiligo

Online now: ILC3s sense gut microbiota through STING to initiate immune tolerance

Online now: Structures of butyrophilin multimers reveal a plier-like mechanism for Vγ9Vδ2 T cell receptor activation

Structures of butyrophilin multimers reveal a plier-like mechanism for Vγ9Vδ2 T cell receptor activation #gdTcells @cp-immunity.bsky.social

It was a huge pleasure to write this spotlight commentary together with @inflammasomelab.bsky.social and @JaredCoombs on the recent Cell paper of Xingbin Hu lab on spectosis in red blood cells! Congrats to all the authors for their novel and elegant study in discovery miniNLRP3 signaling in RBC 👇