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crismunozp.bsky.social
Scientist by day, defender of lost causes by night. Especially the right to not spend our lives filling online forms. Cell death, Cancer metabolism, Metabolic stress, ISR/UPR, mesothelioma and lung cancer
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Not a North-South or a West-East divide. Spain has nearly 50-50% women in science and engineering

AX-NSPARC confocal demo delivers so far. Large field of view *and* super-resolution! Cell phone capture straight from the scope monitor #realtimemicroscopy

Our latest in PNAS! 🎉 ATP-sensitive potassium channels alter glycolytic flux to modulate cortical activity and sleep Take home message? KATP channels are metabolic sensors under circadian control that gate glycolytic flux, arousal, & sleep/wake transitions. www.pnas.org/doi/10.1073/...

GDP/GTP synthesis identified as a target for ALK-driven NSCLC GUK1 activation is a metabolic liability in lung cancer: Cell Jaime Schneider, Marcia Haigis et al www.cell.com/cell/fulltex...

Science is absolutely key to the US's success but this government's intention to now dramatically reduce the part of the federal grants that go to the university (in addition to the researchers; the "indirects") is like removing the unseen roots of a tree and expecting it to continue to flourish.

1. Today the NIH director issued a new directive slashing overhead rates to 15%. I want to provide some context on what that means and why it matters. grants.nih.gov/grants/guide...

ICYMI by First Release - now officially in print @science.org Specific combinations of nutrients and metabolic enzymes determine T cell differentiation via loci-specific histone acetylations. https://buff.ly/4gvqKTz From Shixin Ma, Sue Kaech @tcellogic.bsky.social et al. #immunometabolism

We are soliciting poster and short talk abstracts for the NYASciences Cancer Metabolism meeting. Just around the corner - join us for awesome metabolism in the Big Apple 🍎 Speakers: Kivanc Birsoy, Christine Chio, Marcia Haigis, Andy Intlekofer, Thales PapaG, Jared Rutter, Dan Wahl, Eileen White

Long list of papers this month on cancer metabolism. Glucose/lactate metabolism, asparaginase and glutamine, mitochondria, immunometabolism, nucleotides, iron/heme, diet and cancer, cachexia, mTOR, AMPK, nutrient sensing ... MetaboList, January 25 metabolist.wordpress.com/2025/02/05/m...

So proud of my group co-PI, Ernest Nadal, new scientific director of the Catalan Institute of Oncology. Interview in Catalan/Valencian lhdigital.cat/noticies/lic...

There is a lazy assumption that all lung cancer is self-inflicted www.theguardian.com/society/2025...

Papers on cell death from January 2025 Caspases, pyroptosis, apoptosis, cytotoxicity, ferroptosis, necroptosis, Bcl-2 family and more! ApoList celldeath.wordpress.com/2025/02/04/a...

Undergraduate students passionate about growth and metabolism, please apply @mentor-program.bsky.social, the first @horizoneu.bsky.social on mTOR pathophysiology: mentor-program.eu

As the new Editor-in-Chief I encourage you to submit your work to Oncogenesis (IF 5,9) www.nature.com/oncsis/ High impact, peer-reviewed open access journal publishing articles exploring mechanistic insight and molecular basis of cancer and related phenomena.

We’re hiring a #postdoc! The Dibble Lab at Harvard Medical School and Beth Israel Deaconess Medical Center in Boston studies the regulatory relationship between #signaling and #metabolic pathways. Email me at [email protected] !

🔵🫁 ¿Cuáles son las causas de la pérdida de masa muscular en pacientes de cáncer de pulmón? 🧑🏻‍⚕️ Ernest Nadal y Regina González nos lo cuentan en este seminario de AEACaP. afectadoscancerdepulmon.com/seminario-we...

More data supporting the hypothesis that the mechanisms of cell suicide (apoptosis, pyroptosis) evolved in the context of self-defense www.science.org/doi/10.1126/...

Let's Start this 2025 (and this new Social) with a Post :) Our review on inter-organ crosstalk driving Cancer Cachexia is now available @cp-trendsendomet.bsky.social Systemic metabolic crosstalk as a driver of cancer cachexia by Wyart et al. #Research #CancerCachexia #Metabolism #Muscle

"DIO-SPOTlight Transgenic Mouse to Functionally Monitor Protein Synthesis Regulated by the Integrated Stress Response" Oliver, Calakos et al The reporter replaces the ATF4 mRNA’s main ORF and repressive uORF2 with cDNAs for fluorescent proteins elifesciences.org/reviewed-pre...

Very unusual, to see ads in English to request applications for these tenure track positions in Spain. A good institution to start!

Today, we report that chronic intermittent fasting impairs beta-cell maturation and function in adolescent mice. Using scRNAseq, we delineated a "maturation score" for beta-cells. Long-term IF good if you're older, might be harmful if you are still developing! 👇 www.cell.com/cell-reports...

If you work on cell death (apoptosis, pyroptosis or any -ptosis), don't miss the European Workshop on Cell Death in May! In lovely Fiuggi (near Rome) Aimed to get as many students and postdocs as possible to present orally, and with very participative poster sessions (PIs as well!) www.ewcd.eu

This camera is not in an exotic country. This is Miami!

Scientists are starting to study—and debate—how the unique features of Bluesky might affect discussions of research and workplace culture, and efforts to engage with the public. scim.ag/428RTYG

My favorite recent paper comes from a non-academic lab. Carmela Sidrauski and colleagues studied how enforcing dimerization of PERK affects cell metabolism. They dissected ATF4-dependent and independent effects. The beauty of the kinetic and dose response analyses! www.nature.com/articles/s41...

#NoTimeToDie! @vijayrathinam.bsky.social Weight &co show @cp-cell.bsky.social that pyroptotic cells release extracellular vesicles which transplant gasdermin D #GSDMD pores to neighboring cells propagating cell death! t.co/XgU6jt15aF Free link to the paper 👉 authors.elsevier.com/a/1kMQgL7PXq...

All this hatred for editors who work around Christmas. Not everybody knows the culture of all countries/individuals. Or that it is “aggressive” to ask you to review around that week Some can add a list of potential reviewers on the 24th, & then it’s automatic reminders. They may not be evil…

Cancer Metabolism: articles from the last few weeks. Amino acids, glucose/fructose/mannose/lactate metabolism, cancer immunometabolism, nutrient sensing, mTOR, lipid metabolism, diet, cachexia and more! MetaboList, Nov-Dec 2024 Happy Christmas/holidays metabolist.wordpress.com/2024/12/23/m...

Latest articles on cell death. Bcl-2 family proteins, death receptors, necroptosis, ferroptosis, pyroptosis, clearance of apoptotic cells, caspases and more! Apolist celldeath.wordpress.com/2024/12/23/a...

Just stumbled on this 💎 of a paper at my end-of-the-year review of the #apoptosis #Bax #Bcl2 literature (i.e., trying to get that last paper out). Can't stress enough how glad I am that this gets reported and has a venue in a high profile journal! 🔬🧪👍👍👍 @natureportfolio.bsky.social

Finally, a paper to cite when reviewers come back asking for the TUDCA experiment

Join us in Austin, TXm Feb 9-10 2025, for an Abcam-sponsored symposium on Cancer and Metabolism. -RJD events.abcam.com/event/cancer...

If you study Bax, check this one out from the Rehm Lab. Thanks Markus and colleagues for taking the time to write it down, publish this, and alert others. www.nature.com/articles/s41...

They didn't tell us in the time management course what to do when you realize that the next two months are fully booked with C tasks that you cannot delegate because you brought them upon you