danieljdrucker.bsky.social - Profile | ThreadSky | a Reddit-style client for Bluesky

It's a big week for GIPR pharmacology! Two great studies out in @natmetabolism.nature.com from Gutgesell et al (www.nature.com/articles/s42...) and Liu et al (www.nature.com/articles/s42...) revealing divergent neural mechanisms engaged by GIPR agonism vs antagonism. Commentary here: rdcu.be/ejPSA

submitted 19 hours ago • 1 comment

With an editorial from the expert, Dr. Alice E. Adriaenssens @cambridgeuni.bsky.social disentangling divergent neural networks that explain the success of both GIPR gain and loss of function strategies for promoting #weightloss #obesity @naturemetabolism.bsky.social www.nature.com/articles/s42...

submitted 22 hours ago • 0 comments

New insights into the actions of GIP agonism vs. antagonism on food intake and body weight in mice from Timo Muller and colleagues #weightloss #obesity @naturemetabolism.bsky.social www.nature.com/articles/s42...

submitted 23 hours ago • 1 comment

The usefulness of deciphering the nuclear 14-3-3ζ interactome to identify novel pro-adipogenic factors and pathways. @glim2016.bsky.social www.sciencedirect.com/science/arti...

submitted 1 day ago • 0 comments

The metabolic syndrome and young-onset dementia, from a nationwide cohort of ~2 million people www.neurology.org/doi/abs/10.1...

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The emerging vascular biology of GLP-1 medicines in people with #T2D and PAD dom-pubs.onlinelibrary.wiley.com/doi/full/10....

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Will molecular resolution of Glucokinase structure yield better drugs for type 2 #diabetes diabetesjournals.org/diabetes/art...

submitted 1 day ago • 1 comment

Congratulations to Dr. Lillian Siu @uhntoronto.bsky.social @uoftmedicine.bsky.social the incoming President of @theaacr.bsky.social @oicr.on.ca

submitted 1 day ago • 0 comments

GLP-1-based therapies for diabetes, obesity and beyond tinyurl.com/ph3fn4eh rdcu.be/ejIM2 This new review by @danieljdrucker.bsky.social profiles GLP-1-based medicines, discussing optimization of pharmacokinetics and tolerability, engagement of new therapeutically useful pathways and safety aspects

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For everything there is a season including 80 tissue transciptomes from non human primates @natcomms.nature.com www.nature.com/articles/s41...

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www.nature.com/articles/s41...

submitted 2 days ago • 0 comments

The OG GLP-1 medicine twice daily Exenatide from the salivary gland of Heloderma Suspectum to the clinic for type 2 #diabetes Approved by the @US_FDA April 28 2005. Happy anniversary to the groundbreaking molecule that launched a new class of transformative medicines #T2D

submitted 2 days ago • 1 comment

While the latest GLP-1 medicines are “new” exenatide was approved April 28 2005. Congratulations to John Eng, Amylin Pharma and the hundreds of visionary persistent investigators who gave birth to the class of GLP-1 medicines for type 2 #diabetes www.youtube.com/watch?v=WiHH...

submitted 2 days ago • 0 comments

Congratulations @stephxie.bsky.social already a star @uhntoronto.bsky.social @pmresearch-uhn.bsky.social

submitted 3 days ago • 1 comment

Bases on studies in mice the authors highlight highlight the critical need for identifying and leveraging beneficial #microbiota exposures during early development to combat #obesity and #diabetes www.sciencedirect.com/science/arti...

submitted 3 days ago • 0 comments

Rare GLP-1 medicine results #T2D #obesity in the real world. How to interpret? Some validation thoughts from Deo & Sattar @cp-trendsendomet.bsky.social www.cell.com/trends/endoc...

submitted 3 days ago • 0 comments

The sky is not the limit. Higher semaglutide doses up to 16mg qw for type 2 #diabetes and overweight or #obesity provide modest additional glucose-lowering effect, with additional weight loss, at the expense of more AEs and treatment discontinuations diabetesjournals.org/care/article...

submitted 3 days ago • 0 comments

When contemplating the credibility of the scientific enterprise, one of the elephants in the room continues to be reproducibility www.nature.com/articles/d41...

submitted 4 days ago • 0 comments

The expanding evidence base and new molecules in the new world of GLP-1 medicines. Beyond #T2D #obesity @naturerevdrugdisc.bsky.social can01.safelinks.protection.outlook.com?url=https%3A...

submitted 4 days ago • 0 comments

The compounding of GLP-1 medicines, safety and efficacy, has been contentious. The courts are starting to opine #weightloss #obesity www.cnbc.com/amp/2025/04/...

submitted 4 days ago • 0 comments

The expanding universe of GLP-1 medicines-with dozens of new molecular entities in the clinic, how will they differentiate beyond #weightloss #obesity #diabetes #heartdiseasen @naturerevdrugdisc.bsky.social www.nature.com/articles/s41...

submitted 4 days ago • 2 comments

More evidence that hepatocyte gluconeogenic gene expression and glucose production are spatially and temporally plastic across the liver lobule, underscoring complexity of defining hepatic insulin resistance and glucose production on a whole-organ level www.nature.com/articles/s42...

submitted 4 days ago • 0 comments

The TEDDY study/major contributions to our understanding of environmental triggers, drivers, and modifiers of autoimmunity, and gene-environment interactions, leading to type 1 #diabetes diabetesjournals.org/care/article...

submitted 5 days ago • 0 comments

Towards cell replacement therapies for #T1D diabetesjournals.org/diabetes/art... #islets

submitted 5 days ago • 0 comments

24 MRI-derived fat distribution and muscle volume measures (UK Biobank, n= 33,122) and #genetics to construct #obesity axes and further illustrate heterogeneity of phenotypes diabetesjournals.org/diabetes/art...

submitted 5 days ago • 0 comments

Congratulations Professor Belsham @uoftmedicine.bsky.social @uoft.bsky.social @denisebelsham.bsky.social

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Inviting all EndoSoc members to this exciting lecture! Prof Waljit Dhillo is a wonderful speaker and extremely engaging. Plan to be there! 🤩👏🏻🧠 @infneuroendo.bsky.social @paneuroendo.bsky.social @bsneuroendo.bsky.social

submitted 5 days ago • 0 comments

Happy birthday 🎉to Dr. Mitch Lazar @pennmedicine.bsky.social recognized this weekend as the recipient of the 2025 George M Kober Medal, the highest honor bestowed by the Association of American Physicians www.pennmedicine.org/news/news-re... @nationalacademies.org

submitted 5 days ago • 0 comments

Optimizing the chronotherapy window for endocrine hormone therapeutics #circadian academic.oup.com/edrv/advance...

submitted 5 days ago • 0 comments

New from Professor Tomas-Delineation of intracellular cholesterol GLP-1R interactions @imperialcollegeldn.bsky.social elifesciences.org/articles/101... @elife.bsky.social

submitted 5 days ago • 0 comments

Studies in #aging mice identify a distinct population of adipocyte progenitor cells that may contribute to age-associated visceral #obesity and related metabolic disorders @science.org www.science.org/doi/10.1126/...

submitted 5 days ago • 0 comments

Beyond #weightlosss #cancer Reinvigorating anti-tumor immunity may depend upon bariatric surgery-associated microbially derived metabolites, namely BCAAs @jclinical-invest.bsky.social insight.jci.org/articles/vie...

submitted 5 days ago • 0 comments

"Just some of the triumphs that have come from our robust biomedical research enterprise. NIDDK, as a reflection of work done across the entire NIH, is a prime example of government monies well spent" The 75th anniversary of #NIDDK #NIH diabetesjournals.org/care/article...

submitted 5 days ago • 0 comments

In studies of inflammation murine nodose ganglia neurons perform real-time encoding of cytokines at the first neural station in a body-brain neuroimmune axis @natcomms.nature.com www.nature.com/articles/s41...

submitted 5 days ago • 0 comments

PNOC/NPYARC neurons identified as an additional critical mediator of leptin action and as a promising target for #obesity therapeutics @cellcellpress.bsky.social www.cell.com/cell/fulltex...?

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Fantastic scientists #diabetes recognized by @easdnews.bsky.social www.easd.org/annual-meeti...

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Routine surveillance of capillary ketone levels in #T1D using SGLTi may represent a DKA mitigation strategy. Bruce Perkins & colleagues @sinaihealth.bsky.social diabetesjournals.org/care/article... ada.silverchair-cdn.com/ada/content_...

submitted 6 days ago • 0 comments

When will we have sufficient safety information for use of GLP-1 medicines in children and adolescents? www.nature.com/articles/s41...

submitted 6 days ago • 0 comments

A crucial role of RFX3 in regulating human islet cell differentiation and its role in suppressing EC specification #islets @diabetologiajnl.bsky.social link.springer.com/article/10.1...

submitted 6 days ago • 0 comments

While the acute inflammatory response during prolonged fasting may serve as a transient adaptive mechanism, it raises concerns regarding potential cardiometabolic effects that could persist after refeeding. www.sciencedirect.com/science/arti...

submitted 7 days ago • 0 comments

A new whey forward for postprandial glucose control in GDM diabetesjournals.org/care/article...

submitted 7 days ago • 0 comments

Based on multiomic data analysis of the WT and ob/ob mouse liver, the authors propose mechanisms and pathways illustrating how #obesity alters the hepatic metabolic response to intermittent fasting www.science.org/doi/10.1126/...

submitted 7 days ago • 0 comments

A look at the renal biology of people with eGFR inferred “shrunken pore syndrome” #T2D @diabetologiajnl.bsky.social link.springer.com/article/10.1...

submitted 7 days ago • 0 comments

The longevity associated acetylome with future therapeutic targets to promote longevity #aging @natcomms.nature.com www.nature.com/articles/s41...

submitted 7 days ago • 0 comments

A previously unanticipated brain–gut axis that acutely attunes #microbiota composition on fast timescales, with potential implications for meal-to-meal adjustments and systemic energy balance control @naturemetabolism.bsky.social www.nature.com/articles/s42...

submitted 7 days ago • 0 comments

Newborns at high risk #T1D colocalization of pQTLs for CTRB1, APOBR, IL7R, CPA1, and PNLIPRP1 with Type 1 diabetes GWAS signals, with Mendelian randomization causally implicates each of these proteins in the aetiology of Type 1 #diabetes @natcomms.nature.com www.nature.com/articles/s41...

submitted 7 days ago • 0 comments

Based on phenotypes in knockout mice with enhanced energy expenditure, the authors propose that drugs that inhibit MOB1 or activate YAP1 and/or FGF21 in adipocytes may be good therapeutic agents for diet-induced #obesity and/or type2 #diabetes www.pnas.org/doi/10.1073/...

submitted 8 days ago • 0 comments

The enigmatic scientific and clinical challenge of irritable bowel syndrome. High unmet need slow progress www.thelancet.com/journals/lan...

submitted 10 days ago • 0 comments

The oral small molecule GLP-1 medicines are coming. Will the performance and pricing match the promise and potential? @elilillyandcompany.bsky.social time.com/7278429/weig... #diabetes #weightloss

submitted 10 days ago • 0 comments