danudwary.secondarymetabolism.com - Profile | ThreadSky

Despite a century of use in #DrugDiscovery, specialized metabolism continues to amaze. Justin Nodwell explores a @plosbiology.org study that uses a novel computational approach to uncover unsuspected functions of a compound produced by #Streptomyces 🧪 Paper: plos.io/43UVUPB Primer: plos.io/4n25bOF

submitted 3 days ago • 0 comments

Next up at #ISBA2025 Manoj Jangra from @gdwantibiotics.bsky.social lab talking about the discovery of the new lassopeptide #antibiotic lariocidine targeting the bacterial ribosome. Very cool story and great talk! www.nature.com/articles/s41... #secmet #amr

submitted 2 days ago • 0 comments

New Session at #ISBA2025 Paul Jensen and @matthutchings.bsky.social talking about the fascinating interactions of actinomycetes with predators and plants… #secmet #bacterialinteractions #naturalproducts

submitted 2 days ago • 1 comment

Hyperdiverse, bioactive, and interaction-specific metabolites produced only in co-culture suggest diverse competitors may fuel secondary metabolism of xylarialean fungi | mSystems journals.asm.org/doi/10.1128/...

submitted 23 hours ago • 0 comments

The last day at #ISBA2025 Hanna Augustijn from @marnixmedema.bsky.social and @gillesvanwezel.bsky.social labs giving a brilliant talk about her PhD project mapping the transcription factors and regulation networks in Actinomycetes. Very cool work! #naturalproducts #secmet #bacterialregulation

submitted 15 hours ago • 1 comment

#secmet

submitted 11 hours ago • 0 comments

This is a vital message: one of the larger reasons BlueSky is refreshingly free of alt-right shitlords is because in the early days we made a gentleperson’s agreement to starve these fuckos out and it worked. No likes, no quotes, no engagement. They got bored and left. Please keep the Old Ways.

submitted 1 day ago • 825 comments

Disappointed by this framing, @npr.org. 🦠 Germ theory isn't just “widely accepted”—it is experimentally proven and foundational to the success of modern medicine. Miasma theory isn’t a competing view...It was discarded because it explains essentially nothing. It's like believing in the Tooth Fairy.

submitted 4 days ago • 2 comments

#secmet

submitted 6 days ago • 0 comments

Save the date!

submitted 6 days ago • 1 comment

Call your senators, demand they shut the Senate down.

submitted 7 days ago • 330 comments

Today in Nature we report a systematic strategy to activate & identify gene sets in plants. We identify 8 new genes from the yew tree's Taxol biosynthetic pathway, enabling us to engineer tobacco with 17- & 20-gene pathways to Taxol precursors baccatin III & deBz-deoxy-Taxol #SingleCell #secmet 🧬🧪🌾

submitted 8 days ago • 2 comments

#secmet

submitted 7 days ago • 1 comment

guys will be like "these people are ruining america" and it'll be a picture of the coolest guys ever

submitted 10 days ago • 243 comments

The #OpenGreenGenomes Project, supported through our #CommunityScience Program, represents 35 major evolutionary plant lineages — including M. polymorpha, or liverwort. For decades it has been used as a model for evolutionary studies. 🖥️🧬🌱 @jleebensmack.bsky.social @maximebonhomme.bsky.social

submitted 10 days ago • 0 comments

Still waiting for the article that’s like “these right wing militia members are in a bubble and it would be healthier if they exposed themselves to left wing ideas”

submitted 11 days ago • 162 comments

Pleased to share our latest work on is up on bioRxiv. Read for insights into how barely specialized metabolism is affected by biotic stress. We show serotonin and novel 2-oxo-tryptamine are produced and speculate on what they do 🌱

submitted 15 days ago • 0 comments

🚨 New preprint! We've developed a bioassay-guided genome mining approach to identify bacterial secondary metabolites that inhibit Zymoseptoria tritici — a major fungal pathogen of wheat. Available now on bioRxiv: doi.org/10.1101/2025...

submitted 16 days ago • 2 comments

Finally online and open access! This revised version has a slightly different title and contains a number of additional supplementary figures, mainly in vitro enzyme assays. Kept me quite busy in the lab at the end of last year! #PlantScience #natprod www.nature.com/articles/s41...

submitted 16 days ago • 3 comments

Ok, possibly controversial opinion on Murderbot - based on the conversations I've had so far - but I'm saying it anyway. I truly do not find the "weird hippie scientists" all that insulting a thing to do to the PreservationAux crew.

submitted 18 days ago • 3 comments

I am happy to introduce to you our new paper on pelagic #Asgard archaea that use #rhodopsins with carotenoid antennas to harvest light energy in the oceans. Structural insights into light-harvesting by antenna-containing rhodopsins in marine Asgard archaea www.nature.com/articles/s41...

submitted 21 days ago • 4 comments

"The U.S. will begin revoking visas of Chinese students, including those with connections to the Chinese Communist Party or studying in critical fields."

submitted 22 days ago • 1 comment

NIH funding supporting the HMMER and Infernal software projects has been terminated. NIH states that our work, as well as all other federally funded research at Harvard, is of no benefit to the US.

submitted 28 days ago • 37 comments

The good stuff

submitted 25 days ago • 0 comments

important thread. @xriskology.bsky.social has been on this miserable philosophical beat for a long time, and knows this stuff cold.

submitted 27 days ago • 2 comments

I encounter more and more people in real life lately who think AI genuinely is some kind of truth machine and it feels like they are living on a different planet in a way that is just incredibly distressing

submitted 30 days ago • 45 comments

In this #GenomeInsider🎧: We delve into stable isotope probing, a powerful, complex process for studying microbial communities — and efforts by the JGI to make the technique more accessible, reproducible & insightful. SIPs with Standards: jgi.doe.gov/user-science... @metarolism.bsky.social 🖥️🧬 🦠

submitted 31 days ago • 0 comments

My ongoing request: If your NSF or NIH grant was terminated--whether at Harvard or elsewhere--please report it here. NSF: grant-watch.us/submit-nsf.h... NIH: grant-watch.us/submit-nih.h... Our trackers are actively used in lawsuits and are often the only record that terminations ever occurred.

submitted 36 days ago • 17 comments

🔥Be sure to read the latest Hot Off the Press article by Bob Hill & @andysuth14.bsky.social at @uofgchem.bsky.social on their selection of 32 recent papers covering the latest research in bioorganic chemistry & novel natural products #natprod Find it below🔽 pubs.rsc.org/en/content/a...

submitted 35 days ago • 0 comments