diegobalboa.bsky.social - Profile | ThreadSky | a Reddit-style client for Bluesky

We link molecular and functional phenotypes of islet cells from donors with type 1 diabetes to understand impaired insulin and glucagon secretion. Immune signalling, nuclear exclusion, mTOR and lysosomes in alpha cell dysfunction. https://www.biorxiv.org/content/10.1101/2025.02.20.639325v1

submitted 4 days ago • 1 comment

Congratulations Dr Hossam Montaser! 🎩 Great discussion with Professor Evans-Molina yesterday @stemmprogram.bsky.social @otonkoskit.bsky.social

submitted 3 days ago • 0 comments

Paper out !!🥳big thanks to all authors @marliesoomen.bsky.social @diego-rt.bsky.social @kaessmannlab.bsky.social @jonathangoeke.bsky.social @lorenzamottes.bsky.social & 'bluesky-less' Lots of interesting new TE (& genes) biology Data fully browsable💻 👉 embryo.helmholtz-munich.de/shiny_embryo/

submitted 4 days ago • 8 comments

It was a pleasure for our team to be able to contribute to this manuscript on Vimentin+ alpha cells in CF 👇🏻 joe.bioscientifica.com/view/journal...

submitted 6 days ago • 0 comments

Excited to share the 3rd first-author paper from my PhD! A big thank you to everyone who participated, and to CIHR and Breakthrough T1D Centre of Excellence at UBC for funding! More details below... www.biorxiv.org/content/10.1...

submitted 7 days ago • 1 comment

www.biorxiv.org/content/10.1... New T1D genetics / genomics by Kyle Gaulton and team !

submitted 7 days ago • 0 comments

New from @jimjohnsonsci.bsky.social & colleagues. New insights into the proteomic profiles and regulation of β cell states through analysis of cells varying in Ins gene activity #islets #diabetes @cp-iscience.bsky.social www.cell.com/iscience/ful...

submitted 7 days ago • 1 comment

I have funding through at least 2031 for postdoctoral researchers with expertise in islet biology or cell-based therapies for, or modelling of, diabetes. Bring your expertise to a country that values it. 🇨🇦 Contact info on my website.

submitted 10 days ago • 12 comments

This is a room where we turn very modest salaries and budgets (and lots of coffee) into new knowledge, life-saving innovations, and technology that feeds business growth. It's literally the loom that spins hay into gold but these numpties are suddenly worried about the cost of hay.

submitted 14 days ago • 240 comments

Most genome editing work to date has been DNA based. A new paper out today assessed a single dose of epigenetic editing (thru PCSK9) for marked (~70%) and durable reduction of LDL cholesterol [in non-human primates] www.nature.com/articles/s41...

submitted 15 days ago • 8 comments

Gene editing technology began by people studying salt marshes. Ozempic began by folks studying the venom of Gila Monsters. Support for basic science has empowered us to understand our world. Tethering it to applications health has transformed and saved countless lives.

submitted 17 days ago • 53 comments

PREPRINT! Park et al. makes the case that we may be misunderstanding heterochromatin for past 30 years due to ChIP-Seq biases... 1/n

submitted 19 days ago • 5 comments

📃January in preprints First preprint list of 2025 is out! Check out the #preprints in #DevBio, #StemCell biology (and related fields) that came out in January. Congrats to everyone involved 🎉 And as usual, let us know if we've missed anything 👀 thenode.biologists.com/january-in-p...

submitted 20 days ago • 0 comments

I have big news: @ellis.eu has launched its 2nd major research center, @ellisfinland.bsky.social! I have agreed to start as founding director & the first call for PI positions is open. This is a major opportunity for outstanding researchers, join us! ellisinstitute.fi/PI-recruit

submitted 21 days ago • 2 comments

Li et al. show that human-reprogrammed vascular endothelial cells vascularize #islets, support dynamic function in microfluidic chambers, and enable subcutaneous cotransplantation to reverse hyperglycemia in diabetic mice. #PancSky #BetaCellSky #Diabetes www.science.org/doi/10.1126/...

submitted 22 days ago • 0 comments

Together with @smandrup.bsky.social and Minna Kaikkonen we are happy to announce the 3rd Edition of the EMBO Workshop on #Enhancers and #Enhanceropathies. This time we will meet during the beautiful Danish summer (June 16-21). Book the dates and register soon!!! meetings.embo.org/event/25-enh...

submitted 25 days ago • 0 comments

📢 CUT&Tag version 3 Sometimes the preprint to paper route can be quite the odyssey. And so in that vein, we are delighted to give you version 3 of our CUT&Tag optimization and benchmarking manuscript: www.biorxiv.org/content/10.1...

submitted 26 days ago • 3 comments

Correcting a pathogenic mitochondrial DNA mutation by base editing in mice | Science Translational Medicine www.science.org/doi/10.1126/...

submitted 25 days ago • 1 comment

The "kitchen sink" of omics to solve the basis for an undiagnosed disease: long read genome , transcriptome, methytome, epigenome, all synchronized (a first) www.nature.com/articles/s41...

submitted 27 days ago • 7 comments

Our GWAS on urine metabolomics revealed novel genes and pathways affecting urine metabolites and evaluated the role of kidney function. Great collaboration between FinnDiane Study, Generation Scotland and the VIKING STUDY! rdcu.be/d5oZQ

submitted 43 days ago • 0 comments

Publications in the past week built substantially on our knowledge of the brain's waste disposal system—glymphatics—and the implications on sleep and brain aging. Featuring exceptional work by Nedergaard Lab and @jonykipnis.bsky.social erictopol.substack.com/p/our-sleep-... open-access

submitted 44 days ago • 48 comments

We've summarised the landscape of human pluripotent stem cell trials worldwide in a review in Cell Stem Cell. Fun fact: Over 1200 patients have to date received treatment with hPSC products in 116 different trials, and more than 100 billion hPSC-derived cells have been dosed! doi.org/10.1016/j.st...

submitted 48 days ago • 0 comments

A mosaic gastruloid model highlights the developmental stage-specific restriction of cell competition in mammalian pre-gastrulation https://www.biorxiv.org/content/10.1101/2025.01.25.634859v1

submitted 30 days ago • 0 comments

We have room and $ for postdoctoral fellows to join our team in beautiful Vancouver 🇨🇦. Get in touch if interested.

submitted 33 days ago • 1 comment

Very excited to share our paper on Gene and Transposable Element expression in mammalian preimplantation development, online today! www.cell.com/cell/fulltex... A short thread to highlight some of our findings 🧵

submitted 35 days ago • 7 comments

New week, new #EISG2025 star speakers! On session 4 -The islet cell in T1D & treatment strategies- we will hear from: - Carmella Evans-Molina (@cevansmo.bsky.social ) - Roberto Mallone (@institutcochin.bsky.social ) - Teresa Rodrigez-Calvo (@teresarc.bsky.social ) Register now at eisg2025.se

submitted 36 days ago • 0 comments

Two recent-ish papers provide good reminders of timeless lessons. 1) From @vidigaljoana.bsky.social: "the process of clonal expansion alone resulted in levels of clonal variation extensive enough to essentially preclude us from determining the functional impact of [miRNA] binding site disruption"

submitted 49 days ago • 1 comment

Nailed it

submitted 41 days ago • 141 comments

I am thrilled that our latest work exploring how cisplatin exposure dysregulates insulin secretion in mice is now online at Diabetes! This project was led by the amazing @laharibasu.bsky.social, with important contributions from many other trainees and collaborators. doi.org/10.2337/db24...

submitted 41 days ago • 5 comments

Drumroll, please! 🥁 Announcing #EISG2025 keynote speakers: - Prof. Lori Sussel – Expert in islet biology, uncovering networks for T1D therapies. - Prof. Klaus H. Kaestner (@kkaestner.bsky.social)– Leader in genetics, mapping islet failure & early T1D events. Don’t miss it! #DiabetesResearch

submitted 42 days ago • 1 comment

The world has passed “peak child”

submitted 43 days ago • 10 comments

our newest preprint! Led by Zoe Grant in my lab and Shuzen Kuang in Katie Pollard's lab here at Gladstone. "Dose-dependent sensitivity of human 3D chromatin to a heart disease-linked transcription factor" 1/n www.biorxiv.org/content/10.1...

submitted 43 days ago • 5 comments

For some time now we’ve been aware that Chiron #gastruloids, while representing well axial elongation, exhibit a shortage of anterior fates. Here www.biorxiv.org/content/10.1... @Dias and colleagues uncover the reason and explain the implications for our understanding of mammalian gastrulation 🧵

submitted 44 days ago • 1 comment

www.biorxiv.org/content/10.1... Here we explore the role of #Wnt and #Nodal signalling during mammalian gastrulation using #gastruloids. Building on the work of many labs, we propose that antagonistic signalling-dependent #modularity in the PS establishes the early mammalian body plan.

submitted 43 days ago • 2 comments

What a cool paper! GPCRs are always doing crazy shit we never expected! www.science.org/doi/10.1126/...

submitted 47 days ago • 1 comment

If you’re interested in doing Postdoc work in Vancouver this is a great opportunity, check out our website and get in touch soon (www.betacell.ca)!

submitted 48 days ago • 0 comments

Now available as preprint: The ENCODE 4 expanded registry of regulatory elements - 2.35M 🧍 human cCREs - 927k 🐭 mouse cCREs www.biorxiv.org/content/10.1... Led by @moorejille.bsky.social, this preprint summarizes data and analyses generated by hundreds of contributors across ENCODE 4

submitted 47 days ago • 2 comments

Sana Biotechnology's first-in-human study of hypoimmune-engineered deceased donor islets shows insulin production & immune evasion without immunosuppression #Diabetes #T1D #CellTherapy ir.sana.com/news-release...

submitted 48 days ago • 2 comments

How to test the functional impact of non-coding variants in vivo? We developed a new method called dual-enSERT, which can quantitatively compare the effects of enhancer variants in live mouse embryos in under two weeks. www.nature.com/articles/s41... 1/n

submitted 50 days ago • 4 comments

Do you know who Douglas Prasher is? Many don't, even though he is the person who cloned the original #GFP gene in the late 1980s. In my short history of plant light #microscopy I also cover a bit of his story - & why he is relatively unknown today, despite the importance of his work. See this 🧵👇

submitted 281 days ago • 3 comments

Stoked to share TWO preprints on mitochondrial pearling! 🎉 We uncover how spontaneous #mitochondria pearling drives #mtDNA nucleoid distribution (doi.org/10.1101/2024...), and @gavsturm.bsky.social et al. dissect the biophysics behind it (doi.org/10.1101/2024...). Details below! 🔬🧵🧪

submitted 64 days ago • 6 comments

Join us in Paris 6-9 May 2025 for the #EvoDevoTempo conference (2nd edition) with a fantastic line up of speakers confirmed!! Organized by @mdiazcuadros.bsky.social @vanderhaeghenp2.bsky.social @bassemh.bsky.social and me. Please RT to spread the word meetings.embo.org/event/25-dev...

submitted 67 days ago • 1 comment

the best peer review one can ask for is when someone uses your work in their own science! check out this awesome synthetic development paper that uses tools developed by Sarah Soliman in our preprint from this year! www.cell.com/cell/abstrac...

submitted 67 days ago • 1 comment

Have you ever wondered how your back formed? The human embryo makes a neural tube (future spinal cord) and somites (trunk muscle/bone) from ~d20. They’re formed at the same time and place, so we used human Trunk-like Structures (hTLS) to investigate their ‘co-development’… (1/7)

submitted 69 days ago • 3 comments

We've wondered for a while why #gastruloids are so sensitive to initial cell numbers. Here www.biorxiv.org/content/10.1... led by U, Fiuza, we explore this & observe effects of a number of variables on final structure and think what this tells us @ embryogenesis #IInNumbersWeTrust #NotInTheGenes

submitted 69 days ago • 0 comments

Wondering which prime editing tool is right for your experiment? Our newest blog post will give you a quick overview of your options! blog.addgene.org/pri...

submitted 73 days ago • 0 comments

1/🚀 Excited to share RegVelo, our new cell model combining RNA velocity with gene regulatory network (GRN) dynamics to model cellular changes and predict in silico perturbations. Here's how it works and why it matters! 🧵👇 biorxiv.org/content/10.1101/2024.12.11.627935v1

submitted 75 days ago • 3 comments