dmcilroy.bsky.social - Profile | ThreadSky | a Reddit-style client for Bluesky

Fuck me, that's quite a list!

submitted 2 hours ago • 0 comments

A Vanity Fair paper on the origin of the pandemic details some of the reasoning behind the FBI's "Moderate confidence" assessment for a lab leak, via a retired FBI senior scientist. It seems they were not aware of key information that rebuts their story 🤯 ▫️1/8 www.vanityfair.com/news/story/i...

submitted 13 hours ago • 10 comments

Very moving survivor story, with important measles stats on encephalitis.

submitted 22 hours ago • 0 comments

Make a huge mistake. Then make a false claim about how you fixed it. They did it for PEPFAR. Now Ebola. I follow this particular topic VERY closely, so here's what really happened and why this isn't true AT ALL...🧵

submitted 1 day ago • 196 comments

These internship programs are so important to get talented young people hooked on scientific research.

submitted 1 day ago • 0 comments

Love this animation!

submitted 1 day ago • 0 comments

Measles virus (MeV) infects & kills T & B immune cells resulting in a short-term drop in white cell count. Once the virus is cleared, this returns to normal with the bonus of solid immunity to MeV. BUT..the killing of T and B cells takes out veteran memory of past immunity..immune amnesia results

submitted 2 days ago • 7 comments

Biographical Feature: In memoriam Pierre Tiollais (1934–2024) journals.asm.org/doi/10.1128/...

submitted 2 days ago • 0 comments

Peto's Paradox—that cancer does not increase with body size of mammals—was wrong. A new, comprehensive study of 263 species documents higher cancer prevalence with increasing body mass. Some large animals (e.g. elephants) have some built-in genetic adaptations www.pnas.org/doi/10.1073/... @pnas.org

submitted 2 days ago • 3 comments

In a paper led by J. Pekar now available online, we revisit claims made last year by Lv et al. about early SARS-CoV-2 sequences. We find that their two T/T genomes were sampled too late to be likely evolutionary intermediates between A and B lineages, and are instead likely derived. ▫️1/ #PopGen

submitted 3 days ago • 2 comments

Final version out @cp-oneearth.bsky.social Collab with people at China Agricultural University & others Legume-rice rotations increase rice yields and carbon sequestration potential globally www.cell.com/one-earth/fu...

submitted 3 days ago • 0 comments

So another Saturday morning in the L2, this time trying to resolve a technical issue that's been plaguing us for months. I wanted to switch the BK pseudotype reporter gene that we use from GFP to secreted luciferase (system developed Chris Buck, btw) and it generally works OK, except that

submitted 5 days ago • 1 comment

This really is excellent: great real-world example.

submitted 5 days ago • 0 comments

H/t @jonwensley.bsky.social over on Threads. Best yet.

submitted 6 days ago • 1 comment

At @science.org today, an important new way we can make major headway into immunologic and infectious diseases. Sequencing the lymphocyte B and T cell receptors and A.I. to accurately make the diagnosis! www.science.org/doi/10.1126/science.adp2407 A seminal study by @anshulkundaje.bsky.social et al

submitted 7 days ago • 4 comments

Holy shit, these loons actually want your kids to catch a life-threatening disease!

submitted 7 days ago • 0 comments

schaechter.asmblog.org/schaechter/2... #MicroSky #PhageSky #CryoEM #CryoET #teamtomo

submitted 7 days ago • 0 comments

Yeah, who needs experts anyway?

submitted 8 days ago • 0 comments

Lateral flow assay for detection of BK polyomavirus in urine. Nice work from Etienne Brochot in Amiens, and Antoine Touzé in Tours! Could make it much easier for clinicians to follow BK nephropathy in KTx patients. doi.org/10.1016/j.jv...

submitted 8 days ago • 0 comments

Great summary of why lab leak is so unlikely.

submitted 9 days ago • 0 comments

Dreadful. Fully Preventable. More of this to come www.washingtonpost.com/health/2025/...

submitted 14 days ago • 28 comments

Worth noting that the measles death rate is "only" about 0.1 to 0.2% because of high quality medical care. In other contexts, CFR can be up to 10%.

submitted 14 days ago • 0 comments

Make measles great again! www.nytimes.com/live/2025/02...

submitted 14 days ago • 5 comments

Dammit! I wish I’d coined this one.

submitted 15 days ago • 0 comments

I think... Happy #DarwinDay

submitted 15 days ago • 1 comment

Your 'doom quote' for today: "We are running the most dangerous experiment in history right now, which is to see how much carbon dioxide the atmosphere can handle before there is an environmental catastrophe." Source: Elon Musk speech at Paris-Sorbonne University, December 2, 2015.

submitted 16 days ago • 15 comments

OUT NOW: Upcycling of polyamides through chemical hydrolysis and engineered Pseudomonas putida Nick Wierckx & co @fz-juelich.de @hhu.de www.nature.com/articles/s41...

submitted 16 days ago • 0 comments

"Some 2.5 million people in 2024 received PrEP through PEPFAR, accounting for more than 90% of those worldwide who initiated this form of prevention.... Stopping those efforts has infuriated champions of PrEP. “It’s outrageous,” Warren says. “This is madness.” By my colleague @cohenjon.bsky.social 🧪

submitted 17 days ago • 8 comments

Les réformes annoncées par l'administration Trump, par leur ampleur et leur brutalité, vont tuer l'enseignement supérieur et la recherche aux États-Unis. Cette nuit, on a appris la limitation des coûts indirects des bourses NIH à 15%. Un fil pour expliquer : 🧵 ▫️1/

submitted 20 days ago • 2 comments

Will Trump administration force PEPFAR to cut PrEP? www.science.org/content/arti...

submitted 20 days ago • 3 comments

How do viruses disarm cellular antiviral responses? Examining a range of both DNA and RNA viruses—including HIV-1 and SARS-CoV-2—researchers in #ScienceSignaling find they support replication by suppressing the STING pathway and preventing it from activating NF-kB. scim.ag/40QhYcz

submitted 20 days ago • 0 comments

End of an era in my undergraduate virology course. This is the last year the GFP-baculovirus expt will run in the lab class.

submitted 20 days ago • 0 comments

I agree with Scott. This is important because: 1. This shows that cattle are susceptible to other H5N1 viruses, not just B3.13. 2. D1.1 viruses are currently transmitting really efficiently through wild birds in North America, and are very widespread. ...

submitted 22 days ago • 4 comments

this is incredibly cool work and good news. prion diseases in humans are horrifying -- like alzheimer's but fatal, and condensed into a year or two of rapid degeneration. the treatment is currently only in mouse trials, but what a beautiful implication for the future of medicine

submitted 24 days ago • 5 comments

“You could open the funding floodgates again tomorrow and you will still have children dying months from now because of this pause” 💯 www.nytimes.com/2025/02/01/h...

submitted 26 days ago • 1 comment

Potential new TB drugs always worth a re-post

submitted 26 days ago • 0 comments