dnatopologylab.bsky.social - Profile | ThreadSky | a Reddit-style client for Bluesky

A brilliant, kind, funny colleague gone too soon. We will miss you Bela. www.merton.ox.ac.uk/news/remembe...

submitted 1 day ago • 0 comments

Tenured full Professorship in Genetics and Molecular Cell Biology at the University Of Cologne, Germany It's an opportunity to rebuild the place that used to be home to luminaries including Benno Müller-Hill, Max Delbruck, Campos-Ortega, Diethard Tautz Maria Leptin, Thomas Langer

submitted 2 days ago • 3 comments

Excited to share James Jusuf's preprint: By integrating Micro-C with SuperRes Live-Imaging we can calibrate genomics&imaging to perform absolute quantification of looping (e.g. this loop is present 3%) We quantify mESC 36k loops: <loops> are generally rare (2.3%) www.biorxiv.org/content/10.1...

submitted 41 days ago • 6 comments

Our new review on how the #chromatin domain is formed in the cell is now available @Curr Opin Struct Biol.📄✨ We critically discuss the domain formation mechanism from a physical perspective, including #phase-separation and #condensation. 📥 Free-download link: authors.elsevier.com/a/1keGn,LqAr...

submitted 6 days ago • 0 comments

🎯Breaking News Enzyme used in meiosis makes the cut in vitro News www.nature.com/articles/d41... Paper 1 doi.org/10.1038/s415... Paper 2 doi.org/10.1038/s415... Paper 3 doi.org/10.1038/s415...

submitted 6 days ago • 0 comments

Our preprint on atomistic modelling of the Campylobacter jejuni lipidome is out!

submitted 8 days ago • 1 comment

The Barr lab @ox.ac.uk has discovered the important role of cell division timing mechanisms in the formation of cancer. The research, funded by Cancer Research UK, provides valuable insight into how damaged cells are normally stopped from growing. ⬇️ bit.ly/202502-barr

submitted 14 days ago • 0 comments

🧬🧪🦠🧫 @science.org www.science.org/doi/10.1126/... @rkoszul.bsky.social @leameneu.bsky.social @christophechapard.bsky.social @chromozz.bsky.social @pasteur.fr @sorbonne-universite.fr @institutcurie.bsky.social + PS www.science.org/doi/epdf/10.... @gfudenberg.bsky.social @vram142.bsky.social

submitted 18 days ago • 0 comments

Our latest work: how can compartmentalization emerge in a eukaryotic genome lacking canonical heterochromatin? By investigating bacterial genomes put in yeast, we show that the presence or absence of transcription is sufficient! #chromatin #3Dgenome #generegulation www.science.org/doi/10.1126/... 👇

submitted 19 days ago • 3 comments

Why do different DNA molecules occupy different places in the nucleus? What drives chromatin compartmentalisation? Read this amazing paper to find out www.science.org/doi/10.1126/... Many congratulations to all the authors of this brilliant work! @rkoszul.bsky.social

submitted 19 days ago • 0 comments

Does anyone else agree? We do: “Bluesky is much better for science. There is much less toxicity, misinformation, and distractions,” wrote one respondent. My feed is almost entirely scientists and I actually get updates on research that is relevant and timely” www.nature.com/articles/d41...

submitted 28 days ago • 0 comments

ICYMI We are recruiting a new Associate Professor in cell and molecular biology, with a preference for immunology, inflammation and/or infection - all defined broadly Come and be our colleague! Deadline 28 Feb, please spread the word! www.path.ox.ac.uk/vacancy/asso...

submitted 35 days ago • 0 comments

Some exciting news, folks. @timcoulson.bsky.social and I have a new science podcast launching soon. Please do follow the account for updates. More details coming very soon!

submitted 31 days ago • 0 comments

Fabulous work from our colleagues in the Barr lab showing how the CPC binds the nucleosome! www.biorxiv.org/content/10.1...

submitted 34 days ago • 0 comments

Friendly reminder of our webinar next Tuesday! See you all there!

submitted 33 days ago • 0 comments

Three-dimensional organization of amoeba Dictyostelium discoideum has fascinating features! Very prominent dots at between convergent gene positions, something never really seen for other species. More about the puzzle and how the team of my PhD colleagues resolves it: doi.org/10.1093/nar/...

submitted 33 days ago • 0 comments

Radical blow to biomedical science in the US due to Trump administration decrees: www.science.org/content/arti...

submitted 34 days ago • 2 comments

If you're interested in chromosome biology (DNA folding, gene regulation, replication, polymer modelling and more) we're organising the below this autumn. It'd be great to see you there. Please share if you can. :-)

submitted 36 days ago • 0 comments

The plasmids described in our recent ‘4G-cloning’ paper for multi-subunit complex expression (www.life-science-alliance.org/content/8/1/...) are now available from @addgene.bsky.social (www.addgene.org/search/catal...). Thanks to Addgene for distribution in this convenient and affordable format!

submitted 34 days ago • 2 comments

Grateful for the opportunity to contribute a little to this great study! Step by step we are beginning to understand how these wonderful machines work....

submitted 40 days ago • 1 comment

The Royal Society's Newton International Fellowships will open for applications next week on 21 January. These fellowships are for non-UK early career scientists who wish to conduct research in the UK. Find out more on our website: #RSGrants royalsociety.org/grants/newto...

submitted 43 days ago • 3 comments

There's nothing more reassuring than knowing that everything is running just as it should be across our glorious Transport for London network.

submitted 58 days ago • 0 comments

Wishing everyone who celebrates a very Merry Christmas.

submitted 65 days ago • 0 comments

In our latest mini review, Toni Valdes and I discuss the potential role(s) of DNA superhelicity in the organization of chromosomes by SMC protein complexes, covering classical biochemistry experiments to recent single-molecule biophysics studies. doi.org/10.1042/BST2...

submitted 69 days ago • 0 comments

Please RT: Associate Professor position in my department at the University of Oxford. Broad search in molecular and cellular biology: my.corehr.com/pls/uoxrecru...

submitted 72 days ago • 1 comment

I have received a Wellcome Discovery Award to study the initiation of eukaryotic DNA replication, with 8 years of funding at the Francis Crick Institute. Looking for a postdoc in molecular mechanisms, cryo-EM, cryo-FIB and in situ structure? Contact me now! 3 postdoc positions advertised soon.

submitted 77 days ago • 17 comments

Yesterday, #DemisHassabis delivered his #Nobel Prize Lecture & referenced a paper on 1st contact between egg and sperm by our @pauligroup.bsky.social, @vdeneke.bsky.social, Andreas Blaha, et al. The study was highlighted as a user case for #AlphaFold - how cool! See: www.youtube.com/live/HnT1VWz...

submitted 79 days ago • 0 comments

Our work on SMC Wadjet is finally out! Congrats to all co-authors!

submitted 85 days ago • 1 comment

We are seeking a motivated postdoc to join our lab! Our research focuses on live-cell imaging/analysis to reveal how chromatin behaves in living cells and how its behavior contributes to cellular functions. www.nature.com/articles/s41... www.science.org/doi/10.1126/... Interested? Please DM me!

submitted 88 days ago • 2 comments

The Vienna Biocenter Summer School 2025 call is now open for talented undergrads, it's a great prog. for students who are interested in the life sciences. training.vbc.ac.at/summer-school/ @impvienna.bsky.social @imbavienna.bsky.social @gmivienna.bsky.social @maxperutzlabs.bsky.social

submitted 89 days ago • 0 comments

Do others sometimes feel, how to put this..., suffocated by molecular detail? I think I've increasingly started to think about synthetic biology approaches to understanding how cells work, perhaps in order to avoid all the baroque molecular detail that reflects history as much as function.

submitted 89 days ago • 3 comments

Two fully funded PhD opportunities in our lab. Interdisciplinary, DNA replication, cancer research, structural biology… deadlines in early Jan. Open to international students. t.co/WEJJIU4zU4 www.findaphd.com/phds/project...

submitted 91 days ago • 0 comments

Our article "MCM double hexamer loading visualized with human proteins" published in Nature today! ❄️🔬🧬🎉🥳 Great collaboration with John Diffley's lab. Congratulations to Florian Weissmann, Julia Greiwe and all other authors! rdcu.be/d1F7m

submitted 91 days ago • 10 comments

Looking forward to sharing a new publication from the lab tomorrow! Something a bit different from us this time around. Stay tuned….

submitted 93 days ago • 2 comments

A community consensus paper about a contentious subject like the Last Eukaryotic Common Ancestor does feel very bluesky in late 2024 doesn't it? It was pretty fun to write. Hopefully you'll have fun reading it:) Kudos to @Tom Richards for his writing and cat herding abilities! plos.io/4g0alq4

submitted 93 days ago • 2 comments

Hope I'm the first to post this all time classic on this platform

submitted 99 days ago • 41 comments

Our new work on the Wadjet (JET) anti-plasmid defence system is out: authors.elsevier.com/a/1iXM53vVUP... Showing structures of SMC complexes on extruded DNA (first time?) and blockage (!) of DNA extrusion by obstacles on DNA and more...

submitted 390 days ago • 0 comments

First post for our first human oocyte paper, finally published today! Congratulations to all authors, especially Bettina Mihalas who bravely traveled across the world to join a yeast lab and start a human oocyte project. Forever grateful! www.sciencedirect.com/science/arti...

submitted 433 days ago • 1 comment