dom-somma.bsky.social - Profile | ThreadSky | a Reddit-style client for Bluesky

Deep mutational scanning of RBP6 in Trypanosoma brucei identifies an essential disordered region rich in positive residues! Key for metacyclogenesis. #Trypanosoma PMID:39885181, Nat Commun 2025, @NatureComms https://doi.org/10.1038/s41467-025-56553-y

submitted 17 days ago • 0 comments

Discover cutting-edge scSPOT: a novel method using a 52-marker CyTOF panel to profile Treg function at the single-cell level. Unveil true immune dynamics! #ImmunologyRevolution PMID:39900891, Nat Commun 2025, @NatureComms https://doi.org/10.1038/s41467-024-55746-1

submitted 17 days ago • 0 comments

Dive into career journeys of PIs in immunology, from mastering lab techniques, securing tenure, to navigating moves and balancing family with research🧗 Based on @yefis-immunology.bsky.social ECR workshop at #ECI2024 A must-read for aspiring immunologists and ECRs!👉 bit.ly/4fXeUkC

submitted 43 days ago • 1 comment

There’s a lot to unpack in our recent Science Advances paper - come check it out! Here’s a thread on what we found. #chromatin #genomics #biophotonics #dna #epigenetics #imaging #northwestern #science #biology #aging #longevity #biomedicine #cpge www.science.org/doi/10.1126/...

submitted 43 days ago • 1 comment

Delighted to have had the opportunity to write this spotlight with @juanquintana.bsky.social and the lab, on the recent @lydialynch.bsky.social paper, showing rhythmicity of IL-17 expression in adipose! Fascinating paper, which raises loads of cool questions #immunosky www.cell.com/immunity/ful...

submitted 43 days ago • 5 comments

The X and Y chromosomes each encodes homologous RNA helicases, DDX3X & DDX3Y. They negatively cross-regulate each other via mRNA destabilization. ◼️ This buffers the protein levels of DDX3X and DDX3Y. genome.cshlp.org/content/earl...

submitted 45 days ago • 0 comments

Discover how #metabolism shapes protein #PTMs! Unveil the intricate dance of modifications & feedback loops that regulate cellular functions. Dive into the 'modification of a modification' phenomenon! #science PMID:39775169, Nat Chem Biol 2025, @nchembio

submitted 45 days ago • 0 comments

That's all for this year! Have a nice break! #LabLife #HappyHolidays

submitted 68 days ago • 0 comments

Checkout out these two bombshell papers from @possuhuanglab.bsky.social @stanfordmedicine.bsky.social, computational design of antigen-specific binders to MHC-I or -II, with applications to next gen targeted therapeutics 🤯

submitted 72 days ago • 0 comments

Our protocol for multiplexed single-cell proteomics is in the Dec issue of Nature Protocols. www.nature.com/articles/s41...

submitted 73 days ago • 1 comment

I keep getting questions that are answered in this @naturemethods.bsky.social article. So, I will re-share it. www.nature.com/articles/s41...

submitted 76 days ago • 2 comments

Having a color-blind colleague is a good reminder that we need to be more careful when designing figures for scientific publication 🧪 My lab has found this page especially useful for selecting color palettes, used in combination with different symbols: thenode.biologists.com/data-visuali...

submitted 80 days ago • 44 comments

Recently, We saw a discussion on the role of open-source in proteomics. Here, experienced developers & researchers maintaining OS tools for years shared this comment to guide newcomers in the field about OS and its role in the field. 💻 #Proteomics #OpenSource chemrxiv.org/engage/chemr...

submitted 80 days ago • 1 comment

Efficiency of sgRNAs in CRISPR varies due to RNA mis-folding! PlatinumCRISPr will select correctly folded sgRNAs.

submitted 84 days ago • 2 comments

Researchers analyzed ~1M peripheral blood mononuclear cells from 474 Asian donors to uncover cell-type-specific, sex, and ancestry-biased alternative splicing, highlighting its link to autoimmune and inflammatory diseases. PMID:39627432, @NatureGenet doi.org/10.1038/s415...

submitted 84 days ago • 0 comments

A landscape of X-inactivation during human T cell development www.nature.com/articles/s41...

submitted 84 days ago • 1 comment

(please amplify) 4% of scientists face an important barrier to an the ENTIRE FIELD of single-cell genomics and here is why

submitted 93 days ago • 9 comments

Congrats to our PhD student Jack Frew for the poster prize 🥳🥳!! @drlucymac.bsky.social #EMDS2024

submitted 90 days ago • 0 comments

Wow! big paper in the IFN-cancer axis, and extremely important to consider in the IFN-inhibitor immune disease space too as innate immune blockers are already marketed with more coming! Congrats to the Hudson team, Monash is so proud of our close affiliation with you. www.nature.com/articles/s41...

submitted 93 days ago • 2 comments

Immune cells change in proportions with age - naive go down, effector go up. www.science.org/doi/10.1126/...

submitted 90 days ago • 2 comments

Our top-rated #bioinformatics #training course 'Omic data analysis and visualisation using R' starts in less than 2 weeks (9 Dec) Perfect for those who want to gain new #DataAnalysis and #omics skills 🤩 Don't miss out! Book your place now 👉 bit.ly/4gXvxOF

submitted 93 days ago • 0 comments

Fantastic and as always enthusiastic talk by @martinguilliams.bsky.social on CRISPR screens / cell-cell interactions within the macrophage niche

submitted 91 days ago • 0 comments

The Human Cell Atlas is yielding detailed maps of human tissues and systems throughout life, along with methods to handle single-cell data. Four scientists reflect in Nature on how the project is transforming our understanding of human biology. 🧪

submitted 92 days ago • 0 comments

Finally out 🥳🥳🥳!!! If you are interested in #DC #DendriticCells #RheumatoidArthritis give a look 👇👇👇

submitted 91 days ago • 0 comments

Stronger promoters not only transcribe more RNA but also show higher effective translation rates.

submitted 92 days ago • 1 comment

www.nature.com/articles/s41... “our findings demonstrate a general mechanism involving how self-RNA structure affect innate sensors-triggering innate response and autoinflammation, and provide a potential strategy for controlling TLR-related autoimmune diseases.” #TLR7 #lupus #SLE

submitted 92 days ago • 0 comments

Gene regulation involves thousands of proteins that bind DNA, yet comprehensively mapping these is challenging. Our paper in Nature Genetics describes ChIP-DIP, a method for genome-wide mapping of hundreds of DNA-protein interactions in a single experiment. www.nature.com/articles/s41...

submitted 92 days ago • 9 comments

We also have a poster at board #71 about how mechanobiology affects macrophage phenotypes #EMDS #EMDS24 #EMDS2024

submitted 92 days ago • 0 comments

If you are attending #EMDS2024 this week, come visit our posters at board #26 about DC heterogeneity, spatial localisation and T-Cell interactions #EMDS #EMDS24

submitted 92 days ago • 0 comments

#EMDS conference ready to start P.S. impressive venue

submitted 92 days ago • 0 comments

Gentle reminder: even if you don't mask regularly, please mask inside airplanes.

submitted 93 days ago • 26 comments

Our latest preprint! - led by @makris1.bsky.social we find that Podoplanin expression in lymphoid tissue fibroblasts regulated their inflammatory signalling and crosstalk with immune cell populations doi.org/10.1101/2022...

submitted 96 days ago • 5 comments

Atlas of the plasma proteome in health and disease in 53,026 adults 👩‍🔬🥼👨‍🔬🧪. #proteomics #proteome #plasma #MedSky 👇👇 www.cell.com/cell/fulltex...

submitted 96 days ago • 12 comments

Bone Marrow Organoid (BMO)! BMO generated from human iPSCs can be used to study hematopoiesis. This one pretends to be a heart. Picture by Savannah Fairley. 🔵DAPI (nuclei) 🌕CD271 (mesenchymal cells) 🔴CD31 (endothelial cells) www.nature.com/articles/s41... #FluorescenceFriday #ImmunoSky 🧪

submitted 96 days ago • 4 comments

www.science.org/doi/10.1126/... “Engineering CAR-T therapies for autoimmune disease and beyond” #CART #autoimmune #SLE #lupus

submitted 97 days ago • 0 comments

1/ 🧬 Single-cell genomics reveals biological variations beyond cell types. Unveiling these in separate latent dim’s is known as disentanglement. Led by @AmirAliMoinfar, we develop DRVI to learn nonlinear, disentangled & interpretable latent spaces. biorxiv.org/content/10.1101/2024.11.06.622266v1

submitted 98 days ago • 3 comments

6th European Single Cell conference has been announced. IGreat science in a lovely city, and this year it will have increased focus on the spatial component. Highly recommend you come to this one.

submitted 98 days ago • 0 comments

I created a simple flow chart to help my lab trainees choose the most appropriate stats test in Prism (*for single-factor comparisons only). Feel free to share with your group if you think it could be helpful first start.

submitted 98 days ago • 21 comments

Check out our updated database of 189 PhD fellowships and funding opportunities. For each fellowship, we provide a description, $ amount, deadline, link to funder and eligibility criteria (such as citizenship). Good luck! Download freely here: research.jhu.edu/rdt/funding-...

submitted 100 days ago • 1 comment

✨This month - Human dendritic cells (DC)✨ using stable isotope labelling in healthy volunteers, we define the circulating lifespan of cDC subsets and explore their role in inflammation - huge thanks to the team and our amazing collaborators doi.org/10.1084/jem....

submitted 100 days ago • 2 comments

The strain on scientific publishing: we set out to characterise the remarkable growth of the scientific literature in the last few years, in spite of declining growth in total scientists. What is going on? direct.mit.edu/qss/article/... A 🧵 1/n #AcademicSky #PhDchat #ScientificPublishing #SciPub

submitted 100 days ago • 48 comments

Dimensionality reduction can "see" structures that do not exist & miss structures that exist. Use it sparingly and evaluate conclusions in the high dimensional data. www.nature.com/articles/s41...

submitted 100 days ago • 2 comments

We have plenty of exciting events to look forward to next year including the #SIGNET2025 joint symposium⭐ This popular event connects #immunologists from across Scotland and champions the work of #ECRs! Register and submit your abstract here 👉 bit.ly/4euIWLO

submitted 100 days ago • 0 comments

proteomicsnews.blogspot.com/2024/11/astr... I need some time to digest ben's blog. And would like to contribute my know-how or my opinion with much respect for Ben. EvoSep: the critical point is how the sample is applied to the tips. How long is centrifuged. Does centrifuging dry out the sample.

submitted 101 days ago • 7 comments

Absolutely thrilled to have won the @einsteinberlin.bsky.social Individual #EinsteinFoundationAward. Big congrats to PubPeer and @helenajambor.bsky.social for winning in their categories.

submitted 100 days ago • 67 comments