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dr-foxpaws-fauxpas.bsky.social
Clinical Oncologist, perpetual student, quizzer & digital artist. Interests: GI, Gynec, Breast, Lung, GU, Lymphomas, CNS & palliative medicine. Building towards a better quality of life for all patients 🐳 Alumnus of JIPMER, Pondicherry, India.
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CDK 4/6 inhibitors form the predominant backbone in hormone positive metastatic breast cancer. A summary of its transformative effect on survivals. #mbc #bcsm #oncsky #breast #cancer

submitted 36 days ago • 1 comment

My take on the #Top5 🔑 studies presented at #SABCS24 for #VuMedi #bcsm #breastcancer @osucccjames.bsky.social @osuwexmed.bsky.social @sabcs.bsky.social

submitted 54 days ago • 1 comment

One of the most common unnoticed electrolyte imbalance in cancer patients - Hypomagnesemia! Do test when indicated by keeping it in your DDx ! Here's a quick run through of causes of ⬇️ Mg in Ca pts - especially keep in mind when using: 💊EGFRibs 💉Platins 💊TKIs 💉Anti HER2 #cancer #oncology #oncsky

submitted 57 days ago • 1 comment

Antibiotics at increased risk of clostridium difficile infection Must know for every clinician! #basics #pharmacology

submitted 59 days ago • 0 comments

Revising FLIPI 1 & 2 in follicular lymphomas Compared with m7 FLIPI - 7 gene Clinicogenetic score - validated in GALLIUM - RCHOP/RCVP ❌ in bendamustine regimens ⚡ EZH2 mutation status -Bendamustine in EZH2 wild type FL -CHOP/CVP in EZH2 mutated FL ✅ ⬆️ PFS #lymsm #lymphoma #oncsky #basics

submitted 60 days ago • 0 comments

Revising FLIPI 1 & 2 in follicular lymphomas Compared with m7 FLIPI - 7 gene Clinicogenetic score - validated in GALLIUM - RCHOP/RCVP ❌ in bendamustine regimens ⚡ EZH2 mutation status -Bendamustine in EZH2 wild type FL -CHOP/CVP in EZH2 mutated FL ✅ ⬆️ PFS #lymsm #lymphoma #oncsky #basics

submitted 60 days ago • 0 comments

Here's a fan #art i made of my favorite #christmas movie! What's christmas without an elf, a dwarf and a magic white bearded grandpa? 😄 Merry Christmas everyone!

submitted 63 days ago • 0 comments

4 diagnoses, 4 livers. 1 endless week. Oncology can be pretty darn humbling. Currently in a spiral of existentialism and confronting one's own mortality.

submitted 66 days ago • 1 comment

How do immuno modulatory agents work in #myeloma? And why does Pomalidomide work even after progression on lenalidomide? Tumor microenvironment plays a major role in myeloma and pathogenesis. Ikarus Transcription factor is key. #cancer #hemesky #blood #oncsky @nihardesai7.bsky.social

submitted 67 days ago • 0 comments

What clinical features should you pick up as an oncologist in a patient receiving systemic therapy? #basics #oncology #oncsky Good to know for medical students and people interested in oncology!

submitted 69 days ago • 1 comment

#Liver transplantation criteria for #HCC - Review from the new ASCO guidelines #oncsky #oncology #cancer

submitted 71 days ago • 0 comments

#cardio toxicity of CML TKIs, multiple myeloma agents and VEGF blockers. ⚠️ VEGFr blockers need more stringent monitoring than anthracyclines and HER2 targeted Mabs! #cancer #myeloma #oncsky

submitted 71 days ago • 1 comment

ICI induced myocarditis ❤️‍🔥 🔬 Patho (EMBx) - Dallas Cx Multifocal inflammatory infiltrates + overt cardiomyocyte loss ⚕️Clinical cTn - new/significant ⬆️⬆️ from baseline - with 1 major/2 minor criteria - Exclude ACS/acute infectious myocarditis #sabcs24 #cancer #bcsm #oncsky #cardio toxicity

submitted 76 days ago • 0 comments

Trials supporting Immunotherapy in operable NSCLC Slides courtesy of the incredible Dr Katsuaki Maehara @katsuaki-maehara.bsky.social #LUNG #cancer #lcsm #oncsky

submitted 77 days ago • 0 comments

Management of leptomeningeal disease 💉 Intrathecal therapy ☢️Response assessment criteria 🧬 Promising areas of research ✅ Treatment algorithm #oncology #oncsky #cns

submitted 77 days ago • 0 comments

Quiz time! Which conventional chemotherapy agents of the below cannot cross BBB? Capecitabine Platinums Temozolomide Doxorubicin #oncsky #chemotherapy #basics #brain #oncology Below is an microanatomic depiction of physiological vs pathological BBB at a microscopic level.

submitted 78 days ago • 1 comment

Pearls of #myeloma wisdom from @vincentrk.bsky.social Quick review algorithm - for transplant eligible and relapsed myeloma #ash24 #heme #hemonc #oncsky

submitted 79 days ago • 0 comments

LEAP program - Lenva and Pembrolizumab in solid tumors A comprehensive list of LEAP group trials A summary of site-wise response rates and PFS Interesting paper! #oncology #oncsky #lcsm www.tandfonline.com/doi/full/10....

submitted 81 days ago • 0 comments

⚡ Doses and indications of lenvatinib - for all FDA approved indications. Along with dose reduction levels A quick reckoner Common Tox: ☢️Diarrhea ☢️Asthenia & mucositis ☢️Proteinuria & HTN ☢️Rash and PPE #oncsky #chemotherapy #basics #oncology

submitted 81 days ago • 0 comments

@vincentrk.bsky.social Welcome to bluesky, my favorite myeloma/hematology teacher 🙏

submitted 83 days ago • 0 comments

Was brushing up a bit about myelodysplastic syndromes. Came across a concise & brilliant article by Dr Garcia Manero - must read! Prognostication, cytogenetics in MDS, the MDS spectrum, treatment algorithms and the IPSS stratification. #heme #hemonc #oncsky

submitted 83 days ago • 0 comments

Opinion: Colostomy free survival would be a very good surrogate marker of QOL for ca rectum. Especially with so many younger patients these days. Their HRQOL and sexual QOL will also come into play with locoregional recurrence. Organ preservation should be our next great frontier. #oncsky #cancer

submitted 84 days ago • 0 comments

TCGA - Gastric Ca Molecular Classification 👁️ EBV - best outcomes following resection, notably absent in GEJ ❌ GS- Lauren Diffuse-poor outcomes, poor chemoresponse 🧬 CIN - Lauren Intestinal - benefit of adj chemo ⬆️ Snapshot of targeted therapies for Gastric adenoca #gi #gastro #cancer #oncsky

submitted 86 days ago • 0 comments

A comprehensive review of evidence supporting EGFR inhibitors in NSCLC ✅ Neoadjuvant - EMERGING ✅ Adjuvant - ADAURA ✅ Unresectable - LAURA ✅ Metastatic - FLAURA, PAPILLON, ACHILLES ✅ Resistant(on vs off target) - MARIPOSA2, HARMONI, immunorx #lung #cancer #lcsm #oncsky

submitted 86 days ago • 0 comments

👑 RCHOP remains king/queen in limited stage DLBCL. ✅ PET adapted therapy - best for assessing risk groups for recurrence. ✅ Polatuzumab - better for Non GCB subtype and elderly subgroup - at the cost of increased neuropathy ☢️RT if decreased chemo tolerance ⬇️ #lymphoma #oncsky #heme #cancers

submitted 87 days ago • 0 comments

I've never related to anything more 🙏

submitted 88 days ago • 0 comments

Patterns of meningeal metastases with radio DDx and spotters 🧠 Pachymeningeal - dural mets - MC - breast, prostate, and lung cancers 🧠Leptomeningeal - pia and arachnoid - MC - breast, lung, melanoma #cancer #oncsky #brain #metastasis #radiology Pic credits : Radiology Assistant

submitted 88 days ago • 0 comments

I also did a thing pretty recently I’m pretty proud of 😊 Having people send me photos from Barnes & Noble across the country has been incredibly surreal and makes my day every time. THANK YOU I donate my portion of the proceeds from TOO YOUNG FOR CANCER. www.amazon.com/gp/aw/d/1639...

submitted 89 days ago • 2 comments

When to avoid concurrent PPIs in #cancer treatment? - antimetabolites - immunorx - TKIs Although there is lack of strong randomised data re the same, retro data has shown diminishing efficacy with concurrent PPIs What is the alternative? #oncsky #chemotherapy #basics #oncology

submitted 88 days ago • 1 comment

Anthracyclines and conversion factor #oncsky #chemotherapy #basics #cancer

submitted 89 days ago • 0 comments

Basic mutational testing required for management of #lung #cancer #lcsm Compiling ASCO/NCCN/ESMO guidelines A crisp summary

submitted 90 days ago • 0 comments

This is how we should be doing Oncology trials - the Dutch SONIA trial looking at treatment sequencing of CDK 4/6 inhibitors in advanced breast cancer. A self funding efficiency trial! #oncsky www.nature.com/articles/s41...

submitted 91 days ago • 1 comment

#ESMO resources from HRR - HRD testing in #ovarian #cancer Along with evidence for #PARPi utility in ovarian cancer #gyn #gcsm ✅Telomeric allelic imbalance, ✅loss of heterozygosity, ✅large scale transitions - form a genomic scar score/instability score >42 significant Myriad score.

submitted 90 days ago • 0 comments

Combination approaches for checkpoint inhibitors - #immunotherapy #cancer #oncsky Very good review article by @pamsharmamdphd.bsky.social

submitted 92 days ago • 1 comment

Very good, concise summary of the gut-brain axis of communication and interoception www.cell.com/current-biol... open-access

submitted 94 days ago • 12 comments

Been thinking a lot lately about that episode of Parks and Rec where Leslie and Tom have to rebrand fluoride in the water as TDazzle in order to get the public to support it.

submitted 93 days ago • 394 comments

⭐️Development and phenotype of regulatory T cells This picture is worth 100 K words! Link to pdf: www.stemcell.com/media/files/...

submitted 93 days ago • 0 comments

Why do we give Prednisone with Abiraterone in #prostate #cancer? #GU #oncsky #oncology

submitted 93 days ago • 0 comments

The hallmarks of cancer immune evasion

submitted 93 days ago • 0 comments